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A concise review of testosterone and bone health

View Article: PubMed Central - PubMed

ABSTRACT

Osteoporosis is a condition causing significant morbidity and mortality in the elderly population worldwide. Age-related testosterone deficiency is the most important factor of bone loss in elderly men. Androgen can influence bone health by binding to androgen receptors directly or to estrogen receptors (ERs) indirectly via aromatization to estrogen. This review summarized the direct and indirect effects of androgens on bone derived from in vitro, in vivo, and human studies. Cellular studies showed that androgen stimulated the proliferation of preosteoblasts and differentiation of osteoblasts. The converted estrogen suppressed osteoclast formation and resorption activity by blocking the receptor activator of nuclear factor k-B ligand pathway. In animal studies, activation of androgen and ERα, but not ERβ, was shown to be important in acquisition and maintenance of bone mass. Human epidemiological studies demonstrated a significant relationship between estrogen and testosterone in bone mineral density and fracture risk, but the relative significance between the two remained debatable. Human experimental studies showed that estrogen was needed in suppressing bone resorption, but both androgen and estrogen were indispensable for bone formation. As a conclusion, maintaining optimal level of androgen is essential in preventing osteoporosis and its complications in elderly men.

No MeSH data available.


Related in: MedlinePlus

The effects of testosterone on bone cells.Abbreviations: RANKL, receptor activator of nuclear factor κ-B ligand; OPG, osteoprotegerin; TGFα, transforming growth factor-alpha.
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f2-cia-11-1317: The effects of testosterone on bone cells.Abbreviations: RANKL, receptor activator of nuclear factor κ-B ligand; OPG, osteoprotegerin; TGFα, transforming growth factor-alpha.

Mentions: The effects of androgens and estrogens on bone cells are summarized in Figure 2.


A concise review of testosterone and bone health
The effects of testosterone on bone cells.Abbreviations: RANKL, receptor activator of nuclear factor κ-B ligand; OPG, osteoprotegerin; TGFα, transforming growth factor-alpha.
© Copyright Policy
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5036835&req=5

f2-cia-11-1317: The effects of testosterone on bone cells.Abbreviations: RANKL, receptor activator of nuclear factor κ-B ligand; OPG, osteoprotegerin; TGFα, transforming growth factor-alpha.
Mentions: The effects of androgens and estrogens on bone cells are summarized in Figure 2.

View Article: PubMed Central - PubMed

ABSTRACT

Osteoporosis is a condition causing significant morbidity and mortality in the elderly population worldwide. Age-related testosterone deficiency is the most important factor of bone loss in elderly men. Androgen can influence bone health by binding to androgen receptors directly or to estrogen receptors (ERs) indirectly via aromatization to estrogen. This review summarized the direct and indirect effects of androgens on bone derived from in vitro, in vivo, and human studies. Cellular studies showed that androgen stimulated the proliferation of preosteoblasts and differentiation of osteoblasts. The converted estrogen suppressed osteoclast formation and resorption activity by blocking the receptor activator of nuclear factor k-B ligand pathway. In animal studies, activation of androgen and ERα, but not ERβ, was shown to be important in acquisition and maintenance of bone mass. Human epidemiological studies demonstrated a significant relationship between estrogen and testosterone in bone mineral density and fracture risk, but the relative significance between the two remained debatable. Human experimental studies showed that estrogen was needed in suppressing bone resorption, but both androgen and estrogen were indispensable for bone formation. As a conclusion, maintaining optimal level of androgen is essential in preventing osteoporosis and its complications in elderly men.

No MeSH data available.


Related in: MedlinePlus