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Cost-effectiveness analysis of online hemodiafiltration versus high-flux hemodialysis

View Article: PubMed Central - PubMed

ABSTRACT

Background: Clinical studies suggest that hemodiafiltration (HDF) may lead to better clinical outcomes than high-flux hemodialysis (HF-HD), but concerns have been raised about the cost-effectiveness of HDF versus HF-HD. Aim of this study was to investigate whether clinical benefits, in terms of longer survival and better health-related quality of life, are worth the possibly higher costs of HDF compared to HF-HD.

Methods: The analysis comprised a simulation based on the combined results of previous published studies, with the following steps: 1) estimation of the survival function of HF-HD patients from a clinical trial and of HDF patients using the risk reduction estimated in a meta-analysis; 2) simulation of the survival of the same sample of patients as if allocated to HF-HD or HDF using three-state Markov models; and 3) application of state-specific health-related quality of life coefficients and differential costs derived from the literature. Several Monte Carlo simulations were performed, including simulations for patients with different risk profiles, for example, by age (patients aged 40, 50, and 60 years), sex, and diabetic status. Scatter plots of simulations in the cost-effectiveness plane were produced, incremental cost-effectiveness ratios were estimated, and cost-effectiveness acceptability curves were computed.

Results: An incremental cost-effectiveness ratio of €6,982/quality-adjusted life years (QALY) was estimated for the baseline cohort of 50-year-old male patients. Given the commonly accepted threshold of €40,000/QALY, HDF is cost-effective. The probabilistic sensitivity analysis showed that HDF is cost-effective with a probability of ~81% at a threshold of €40,000/QALY. It is fundamental to measure the outcome also in terms of quality of life. HDF is more cost-effective for younger patients.

Conclusion: HDF can be considered cost-effective compared to HF-HD.

No MeSH data available.


Cost-effectiveness acceptability curves for female and male patients aged 40, 50, and 60 years on hemodiafiltration.
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f4-ceor-8-531: Cost-effectiveness acceptability curves for female and male patients aged 40, 50, and 60 years on hemodiafiltration.

Mentions: The same analyses were carried out for the subgroups of 40-, 50-, and 60-year-old male and female patients (Table 1): HDF appears to be more cost-effective for younger patients. This message is reinforced in Figure 4, which shows that a given threshold value is associated to a higher probability of HDF being cost-effective for the 40- and 50-year-old patients than for the 60-year-old ones. Moreover, for the 60-year-old groups there is a probability of around 28% for both females and males that HDF is not cost-effective even at extreme values of the threshold.


Cost-effectiveness analysis of online hemodiafiltration versus high-flux hemodialysis
Cost-effectiveness acceptability curves for female and male patients aged 40, 50, and 60 years on hemodiafiltration.
© Copyright Policy
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5036827&req=5

f4-ceor-8-531: Cost-effectiveness acceptability curves for female and male patients aged 40, 50, and 60 years on hemodiafiltration.
Mentions: The same analyses were carried out for the subgroups of 40-, 50-, and 60-year-old male and female patients (Table 1): HDF appears to be more cost-effective for younger patients. This message is reinforced in Figure 4, which shows that a given threshold value is associated to a higher probability of HDF being cost-effective for the 40- and 50-year-old patients than for the 60-year-old ones. Moreover, for the 60-year-old groups there is a probability of around 28% for both females and males that HDF is not cost-effective even at extreme values of the threshold.

View Article: PubMed Central - PubMed

ABSTRACT

Background: Clinical studies suggest that hemodiafiltration (HDF) may lead to better clinical outcomes than high-flux hemodialysis (HF-HD), but concerns have been raised about the cost-effectiveness of HDF versus HF-HD. Aim of this study was to investigate whether clinical benefits, in terms of longer survival and better health-related quality of life, are worth the possibly higher costs of HDF compared to HF-HD.

Methods: The analysis comprised a simulation based on the combined results of previous published studies, with the following steps: 1) estimation of the survival function of HF-HD patients from a clinical trial and of HDF patients using the risk reduction estimated in a meta-analysis; 2) simulation of the survival of the same sample of patients as if allocated to HF-HD or HDF using three-state Markov models; and 3) application of state-specific health-related quality of life coefficients and differential costs derived from the literature. Several Monte Carlo simulations were performed, including simulations for patients with different risk profiles, for example, by age (patients aged 40, 50, and 60 years), sex, and diabetic status. Scatter plots of simulations in the cost-effectiveness plane were produced, incremental cost-effectiveness ratios were estimated, and cost-effectiveness acceptability curves were computed.

Results: An incremental cost-effectiveness ratio of €6,982/quality-adjusted life years (QALY) was estimated for the baseline cohort of 50-year-old male patients. Given the commonly accepted threshold of €40,000/QALY, HDF is cost-effective. The probabilistic sensitivity analysis showed that HDF is cost-effective with a probability of ~81% at a threshold of €40,000/QALY. It is fundamental to measure the outcome also in terms of quality of life. HDF is more cost-effective for younger patients.

Conclusion: HDF can be considered cost-effective compared to HF-HD.

No MeSH data available.