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Associations of Cholesteryl Ester Transfer Protein TaqIB Polymorphism with the Composite Ischemic Cardiovascular Disease Risk and HDL-C Concentrations: A Meta-Analysis

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ABSTRACT

Background: Previous studies have evaluated the associations between the cholesteryl ester transfer protein (CETP) TaqIB polymorphism (rs708272), the risk of developing composite ischemic cardiovascular disease (CVD) and the concentration of high-density lipoprotein cholesterol (HDL-C), but results remain controversial. The objective of this study was to investigate whether a relationship exists between these factors. Methods: We conducted a meta-analysis of available studies to clarify the associations of the CETP TaqIB polymorphism with HDL-C concentration and the composite ischemic CVD risk in both Asians and Caucasians. All statistical analyses were done with Stata 12.0. Results: Through utilization of the Cochrane Library, Embase, PubMed, Web of Science, Springer, China Science and Technology Journal Database, China National Knowledge Infrastructure, Google Scholar, and Baidu Library, a total of 45 studies from 44 papers with 20,866 cases and 21,298 controls were combined showing a significant association between the CETP TaqIB variant and composite ischemic CVD risk. Carriers of allele TaqIB-B1 were found to have a higher risk of composite ischemic CVD than non-carriers: OR = 1.15, 95% CI = 1.09–1.21, p < 0.001. Meanwhile, 28 studies with 23,959 subjects were included in the association between the CETP TaqIB polymorphism and the concentration of HDL-C. Results suggested that carriers of the B1B1 genotype had lower concentrations of HDL-C than those of the B2B2 genotype: SMD = 0.50, 95% CI = 0.36–0.65, p < 0.001. Conclusions: The synthesis of available evidence demonstrates that the CETP TaqIB polymorphism protects against composite ischemic CVD risk and is associated with a higher HDL-C concentration in both Asians and Caucasians.

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Funnel plot for allele comparison of atherosclerosis and the CETP TaqIB polymorphism. Each small circle represents a separate study for the indicated association.
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ijerph-13-00882-f004: Funnel plot for allele comparison of atherosclerosis and the CETP TaqIB polymorphism. Each small circle represents a separate study for the indicated association.

Mentions: Funnel plots and Egger’s test were performed to access the publication bias of literature. For the CETP polymorphism and the composite ischemic CVD risk analysis (B1 vs. B2), the shape of the funnel plot (Figure 4) did not reveal obvious asymmetry, which means no publication bias. This was confirmed by Egger’s test (p = 0.074). For the CETP polymorphism and HDL-C analysis (B1B1 vs. B2B2), neither the shape of the funnel plot (Figure 5) nor Egger’s test (p = 0.058) revealed any obvious asymmetry.


Associations of Cholesteryl Ester Transfer Protein TaqIB Polymorphism with the Composite Ischemic Cardiovascular Disease Risk and HDL-C Concentrations: A Meta-Analysis
Funnel plot for allele comparison of atherosclerosis and the CETP TaqIB polymorphism. Each small circle represents a separate study for the indicated association.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5036715&req=5

ijerph-13-00882-f004: Funnel plot for allele comparison of atherosclerosis and the CETP TaqIB polymorphism. Each small circle represents a separate study for the indicated association.
Mentions: Funnel plots and Egger’s test were performed to access the publication bias of literature. For the CETP polymorphism and the composite ischemic CVD risk analysis (B1 vs. B2), the shape of the funnel plot (Figure 4) did not reveal obvious asymmetry, which means no publication bias. This was confirmed by Egger’s test (p = 0.074). For the CETP polymorphism and HDL-C analysis (B1B1 vs. B2B2), neither the shape of the funnel plot (Figure 5) nor Egger’s test (p = 0.058) revealed any obvious asymmetry.

View Article: PubMed Central - PubMed

ABSTRACT

Background: Previous studies have evaluated the associations between the cholesteryl ester transfer protein (CETP) TaqIB polymorphism (rs708272), the risk of developing composite ischemic cardiovascular disease (CVD) and the concentration of high-density lipoprotein cholesterol (HDL-C), but results remain controversial. The objective of this study was to investigate whether a relationship exists between these factors. Methods: We conducted a meta-analysis of available studies to clarify the associations of the CETP TaqIB polymorphism with HDL-C concentration and the composite ischemic CVD risk in both Asians and Caucasians. All statistical analyses were done with Stata 12.0. Results: Through utilization of the Cochrane Library, Embase, PubMed, Web of Science, Springer, China Science and Technology Journal Database, China National Knowledge Infrastructure, Google Scholar, and Baidu Library, a total of 45 studies from 44 papers with 20,866 cases and 21,298 controls were combined showing a significant association between the CETP TaqIB variant and composite ischemic CVD risk. Carriers of allele TaqIB-B1 were found to have a higher risk of composite ischemic CVD than non-carriers: OR = 1.15, 95% CI = 1.09–1.21, p < 0.001. Meanwhile, 28 studies with 23,959 subjects were included in the association between the CETP TaqIB polymorphism and the concentration of HDL-C. Results suggested that carriers of the B1B1 genotype had lower concentrations of HDL-C than those of the B2B2 genotype: SMD = 0.50, 95% CI = 0.36–0.65, p < 0.001. Conclusions: The synthesis of available evidence demonstrates that the CETP TaqIB polymorphism protects against composite ischemic CVD risk and is associated with a higher HDL-C concentration in both Asians and Caucasians.

No MeSH data available.


Related in: MedlinePlus