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Associations of Cholesteryl Ester Transfer Protein TaqIB Polymorphism with the Composite Ischemic Cardiovascular Disease Risk and HDL-C Concentrations: A Meta-Analysis

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ABSTRACT

Background: Previous studies have evaluated the associations between the cholesteryl ester transfer protein (CETP) TaqIB polymorphism (rs708272), the risk of developing composite ischemic cardiovascular disease (CVD) and the concentration of high-density lipoprotein cholesterol (HDL-C), but results remain controversial. The objective of this study was to investigate whether a relationship exists between these factors. Methods: We conducted a meta-analysis of available studies to clarify the associations of the CETP TaqIB polymorphism with HDL-C concentration and the composite ischemic CVD risk in both Asians and Caucasians. All statistical analyses were done with Stata 12.0. Results: Through utilization of the Cochrane Library, Embase, PubMed, Web of Science, Springer, China Science and Technology Journal Database, China National Knowledge Infrastructure, Google Scholar, and Baidu Library, a total of 45 studies from 44 papers with 20,866 cases and 21,298 controls were combined showing a significant association between the CETP TaqIB variant and composite ischemic CVD risk. Carriers of allele TaqIB-B1 were found to have a higher risk of composite ischemic CVD than non-carriers: OR = 1.15, 95% CI = 1.09–1.21, p < 0.001. Meanwhile, 28 studies with 23,959 subjects were included in the association between the CETP TaqIB polymorphism and the concentration of HDL-C. Results suggested that carriers of the B1B1 genotype had lower concentrations of HDL-C than those of the B2B2 genotype: SMD = 0.50, 95% CI = 0.36–0.65, p < 0.001. Conclusions: The synthesis of available evidence demonstrates that the CETP TaqIB polymorphism protects against composite ischemic CVD risk and is associated with a higher HDL-C concentration in both Asians and Caucasians.

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Association between the CETP TaqIB polymorphism and HDL-C level (B1B1 vs. B2B2).
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ijerph-13-00882-f003: Association between the CETP TaqIB polymorphism and HDL-C level (B1B1 vs. B2B2).

Mentions: Figure 3 describes the results of the meta-analysis of the CETP TaqIB polymorphism and HDL-C concentrations. Our analysis strongly suggested that carriers of the B1B1 genotype had lower concentrations of HDL-C than those of the B2B2 genotype (B1B1 vs. B2B2: SMD = 0.50, 95% CI = 0.36–0.65). We also compared carriers of the B1B1 genotype with those of the B1B2 genotype (Figure S4: B1B1 vs. B1B2: SMD = 0.18, 95% CI = 0.10–0.26) and B1B2 genotype with those of B2B2 genotype (Figure S5: B1B2 vs. B2B2: SMD = 0.32, 95% CI = 0.21–0.42). Subgroup analyses by ethnicity confirmed that the relationship between the CETP TaqIB-B2 polymorphism and the HDL-C concentration in Asians was less consistent than that in Caucasians (Figure 2, Figures S4 and S5).


Associations of Cholesteryl Ester Transfer Protein TaqIB Polymorphism with the Composite Ischemic Cardiovascular Disease Risk and HDL-C Concentrations: A Meta-Analysis
Association between the CETP TaqIB polymorphism and HDL-C level (B1B1 vs. B2B2).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5036715&req=5

ijerph-13-00882-f003: Association between the CETP TaqIB polymorphism and HDL-C level (B1B1 vs. B2B2).
Mentions: Figure 3 describes the results of the meta-analysis of the CETP TaqIB polymorphism and HDL-C concentrations. Our analysis strongly suggested that carriers of the B1B1 genotype had lower concentrations of HDL-C than those of the B2B2 genotype (B1B1 vs. B2B2: SMD = 0.50, 95% CI = 0.36–0.65). We also compared carriers of the B1B1 genotype with those of the B1B2 genotype (Figure S4: B1B1 vs. B1B2: SMD = 0.18, 95% CI = 0.10–0.26) and B1B2 genotype with those of B2B2 genotype (Figure S5: B1B2 vs. B2B2: SMD = 0.32, 95% CI = 0.21–0.42). Subgroup analyses by ethnicity confirmed that the relationship between the CETP TaqIB-B2 polymorphism and the HDL-C concentration in Asians was less consistent than that in Caucasians (Figure 2, Figures S4 and S5).

View Article: PubMed Central - PubMed

ABSTRACT

Background: Previous studies have evaluated the associations between the cholesteryl ester transfer protein (CETP) TaqIB polymorphism (rs708272), the risk of developing composite ischemic cardiovascular disease (CVD) and the concentration of high-density lipoprotein cholesterol (HDL-C), but results remain controversial. The objective of this study was to investigate whether a relationship exists between these factors. Methods: We conducted a meta-analysis of available studies to clarify the associations of the CETP TaqIB polymorphism with HDL-C concentration and the composite ischemic CVD risk in both Asians and Caucasians. All statistical analyses were done with Stata 12.0. Results: Through utilization of the Cochrane Library, Embase, PubMed, Web of Science, Springer, China Science and Technology Journal Database, China National Knowledge Infrastructure, Google Scholar, and Baidu Library, a total of 45 studies from 44 papers with 20,866 cases and 21,298 controls were combined showing a significant association between the CETP TaqIB variant and composite ischemic CVD risk. Carriers of allele TaqIB-B1 were found to have a higher risk of composite ischemic CVD than non-carriers: OR = 1.15, 95% CI = 1.09–1.21, p < 0.001. Meanwhile, 28 studies with 23,959 subjects were included in the association between the CETP TaqIB polymorphism and the concentration of HDL-C. Results suggested that carriers of the B1B1 genotype had lower concentrations of HDL-C than those of the B2B2 genotype: SMD = 0.50, 95% CI = 0.36–0.65, p < 0.001. Conclusions: The synthesis of available evidence demonstrates that the CETP TaqIB polymorphism protects against composite ischemic CVD risk and is associated with a higher HDL-C concentration in both Asians and Caucasians.

No MeSH data available.


Related in: MedlinePlus