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Associations of Cholesteryl Ester Transfer Protein TaqIB Polymorphism with the Composite Ischemic Cardiovascular Disease Risk and HDL-C Concentrations: A Meta-Analysis

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ABSTRACT

Background: Previous studies have evaluated the associations between the cholesteryl ester transfer protein (CETP) TaqIB polymorphism (rs708272), the risk of developing composite ischemic cardiovascular disease (CVD) and the concentration of high-density lipoprotein cholesterol (HDL-C), but results remain controversial. The objective of this study was to investigate whether a relationship exists between these factors. Methods: We conducted a meta-analysis of available studies to clarify the associations of the CETP TaqIB polymorphism with HDL-C concentration and the composite ischemic CVD risk in both Asians and Caucasians. All statistical analyses were done with Stata 12.0. Results: Through utilization of the Cochrane Library, Embase, PubMed, Web of Science, Springer, China Science and Technology Journal Database, China National Knowledge Infrastructure, Google Scholar, and Baidu Library, a total of 45 studies from 44 papers with 20,866 cases and 21,298 controls were combined showing a significant association between the CETP TaqIB variant and composite ischemic CVD risk. Carriers of allele TaqIB-B1 were found to have a higher risk of composite ischemic CVD than non-carriers: OR = 1.15, 95% CI = 1.09–1.21, p < 0.001. Meanwhile, 28 studies with 23,959 subjects were included in the association between the CETP TaqIB polymorphism and the concentration of HDL-C. Results suggested that carriers of the B1B1 genotype had lower concentrations of HDL-C than those of the B2B2 genotype: SMD = 0.50, 95% CI = 0.36–0.65, p < 0.001. Conclusions: The synthesis of available evidence demonstrates that the CETP TaqIB polymorphism protects against composite ischemic CVD risk and is associated with a higher HDL-C concentration in both Asians and Caucasians.

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Meta-analysis of atherosclerosis and the CETP TaqIB polymorphism (B1 vs. B2).
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ijerph-13-00882-f002: Meta-analysis of atherosclerosis and the CETP TaqIB polymorphism (B1 vs. B2).

Mentions: The results of all 45 comparisons showed evidence of a significant association between the CETP TaqIB polymorphism and the composite ischemic CVD, suggesting that carriers of allele TaqIB-B1 have a higher risk of the composite ischemic CVD than non-carriers (OR = 1.15, 95% CI = 1.09–1.21) (Figure 2). The additive genetic model (B1B1 vs. B2B2: OR = 1.26, 95% CI = 1.19–1.34), dominant genetic model (B1B1 + B1B2 vs. B2B2: OR = 1.20, 95% CI = 1.14–1.27), and recessive genetic model (B1B1 vs. B1B2 + B2B2: OR = 1.13, 95% CI = 1.08–1.18) were also included in the analysis and results were similar with allele comparison (Figures S1–S3). Subgroup analyses by ethnicity showed significant associations in Asians consistent with that in Caucasians. In addition, significant associations were also found between this variant and susceptibility to the composite ischemic CVD in the population-based group, the hospital-based group, the CAD group, the MI group, the IS group, the case control study group, and the cohort study group, respectively. We also observed the association between CETP TaqIB-B2 polymorphism and the composite ischemic CVD risk where was stronger in the Asian than the Caucasians. The main results of the meta-analysis are shown in Table 3.


Associations of Cholesteryl Ester Transfer Protein TaqIB Polymorphism with the Composite Ischemic Cardiovascular Disease Risk and HDL-C Concentrations: A Meta-Analysis
Meta-analysis of atherosclerosis and the CETP TaqIB polymorphism (B1 vs. B2).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5036715&req=5

ijerph-13-00882-f002: Meta-analysis of atherosclerosis and the CETP TaqIB polymorphism (B1 vs. B2).
Mentions: The results of all 45 comparisons showed evidence of a significant association between the CETP TaqIB polymorphism and the composite ischemic CVD, suggesting that carriers of allele TaqIB-B1 have a higher risk of the composite ischemic CVD than non-carriers (OR = 1.15, 95% CI = 1.09–1.21) (Figure 2). The additive genetic model (B1B1 vs. B2B2: OR = 1.26, 95% CI = 1.19–1.34), dominant genetic model (B1B1 + B1B2 vs. B2B2: OR = 1.20, 95% CI = 1.14–1.27), and recessive genetic model (B1B1 vs. B1B2 + B2B2: OR = 1.13, 95% CI = 1.08–1.18) were also included in the analysis and results were similar with allele comparison (Figures S1–S3). Subgroup analyses by ethnicity showed significant associations in Asians consistent with that in Caucasians. In addition, significant associations were also found between this variant and susceptibility to the composite ischemic CVD in the population-based group, the hospital-based group, the CAD group, the MI group, the IS group, the case control study group, and the cohort study group, respectively. We also observed the association between CETP TaqIB-B2 polymorphism and the composite ischemic CVD risk where was stronger in the Asian than the Caucasians. The main results of the meta-analysis are shown in Table 3.

View Article: PubMed Central - PubMed

ABSTRACT

Background: Previous studies have evaluated the associations between the cholesteryl ester transfer protein (CETP) TaqIB polymorphism (rs708272), the risk of developing composite ischemic cardiovascular disease (CVD) and the concentration of high-density lipoprotein cholesterol (HDL-C), but results remain controversial. The objective of this study was to investigate whether a relationship exists between these factors. Methods: We conducted a meta-analysis of available studies to clarify the associations of the CETP TaqIB polymorphism with HDL-C concentration and the composite ischemic CVD risk in both Asians and Caucasians. All statistical analyses were done with Stata 12.0. Results: Through utilization of the Cochrane Library, Embase, PubMed, Web of Science, Springer, China Science and Technology Journal Database, China National Knowledge Infrastructure, Google Scholar, and Baidu Library, a total of 45 studies from 44 papers with 20,866 cases and 21,298 controls were combined showing a significant association between the CETP TaqIB variant and composite ischemic CVD risk. Carriers of allele TaqIB-B1 were found to have a higher risk of composite ischemic CVD than non-carriers: OR = 1.15, 95% CI = 1.09–1.21, p < 0.001. Meanwhile, 28 studies with 23,959 subjects were included in the association between the CETP TaqIB polymorphism and the concentration of HDL-C. Results suggested that carriers of the B1B1 genotype had lower concentrations of HDL-C than those of the B2B2 genotype: SMD = 0.50, 95% CI = 0.36–0.65, p < 0.001. Conclusions: The synthesis of available evidence demonstrates that the CETP TaqIB polymorphism protects against composite ischemic CVD risk and is associated with a higher HDL-C concentration in both Asians and Caucasians.

No MeSH data available.


Related in: MedlinePlus