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Associations of Cholesteryl Ester Transfer Protein TaqIB Polymorphism with the Composite Ischemic Cardiovascular Disease Risk and HDL-C Concentrations: A Meta-Analysis

View Article: PubMed Central - PubMed

ABSTRACT

Background: Previous studies have evaluated the associations between the cholesteryl ester transfer protein (CETP) TaqIB polymorphism (rs708272), the risk of developing composite ischemic cardiovascular disease (CVD) and the concentration of high-density lipoprotein cholesterol (HDL-C), but results remain controversial. The objective of this study was to investigate whether a relationship exists between these factors. Methods: We conducted a meta-analysis of available studies to clarify the associations of the CETP TaqIB polymorphism with HDL-C concentration and the composite ischemic CVD risk in both Asians and Caucasians. All statistical analyses were done with Stata 12.0. Results: Through utilization of the Cochrane Library, Embase, PubMed, Web of Science, Springer, China Science and Technology Journal Database, China National Knowledge Infrastructure, Google Scholar, and Baidu Library, a total of 45 studies from 44 papers with 20,866 cases and 21,298 controls were combined showing a significant association between the CETP TaqIB variant and composite ischemic CVD risk. Carriers of allele TaqIB-B1 were found to have a higher risk of composite ischemic CVD than non-carriers: OR = 1.15, 95% CI = 1.09–1.21, p < 0.001. Meanwhile, 28 studies with 23,959 subjects were included in the association between the CETP TaqIB polymorphism and the concentration of HDL-C. Results suggested that carriers of the B1B1 genotype had lower concentrations of HDL-C than those of the B2B2 genotype: SMD = 0.50, 95% CI = 0.36–0.65, p < 0.001. Conclusions: The synthesis of available evidence demonstrates that the CETP TaqIB polymorphism protects against composite ischemic CVD risk and is associated with a higher HDL-C concentration in both Asians and Caucasians.

No MeSH data available.


Flow diagram of the study selection process.
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ijerph-13-00882-f001: Flow diagram of the study selection process.

Mentions: The present study met the PRISMA statements (Checklist S1) and MOOSE guidelines (Table S1). The study selection process is detailed in Figure 1. Through a comprehensive retrieval and evaluation, 45 studies from 44 papers with 20,866 cases and 21,298 controls met the inclusion criteria to assess the association between the CETPTaqIB polymorphism and the composite ischemic CVD [23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65]. The selected study characteristics and data are listed in Table 1. Among these studies, 28 involved CAD [23,24,25,26,27,28,29,30,31,32,34,35,36,37,38,39,44,46,47,50,52,53,54,55,59,60,61,66], three involved IS [63,64,65], and 14 involved MI [33,40,41,42,43,45,48,49,51,56,57,58,62]. In addition, there were 26 studies on Caucasians [23,24,25,27,30,38,39,40,41,42,43,44,45,47,48,50,51,53,56,57,58,60,62,63,64] and 19 studies on Asians [26,28,29,31,32,33,34,35,36,37,46,49,52,54,55,59,61,65,66]. Controls of 23 studies were hospital-based [23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,57,58,59,61,63,64,65,66], while those of the other 22 studies were population-based [38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,60,62]. Seven studies did not follow the Hardy-Weinberg equilibrium [23,35,36,40,42,43,58]. In addition, NOS results showed that the average scores were 6.8.


Associations of Cholesteryl Ester Transfer Protein TaqIB Polymorphism with the Composite Ischemic Cardiovascular Disease Risk and HDL-C Concentrations: A Meta-Analysis
Flow diagram of the study selection process.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5036715&req=5

ijerph-13-00882-f001: Flow diagram of the study selection process.
Mentions: The present study met the PRISMA statements (Checklist S1) and MOOSE guidelines (Table S1). The study selection process is detailed in Figure 1. Through a comprehensive retrieval and evaluation, 45 studies from 44 papers with 20,866 cases and 21,298 controls met the inclusion criteria to assess the association between the CETPTaqIB polymorphism and the composite ischemic CVD [23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65]. The selected study characteristics and data are listed in Table 1. Among these studies, 28 involved CAD [23,24,25,26,27,28,29,30,31,32,34,35,36,37,38,39,44,46,47,50,52,53,54,55,59,60,61,66], three involved IS [63,64,65], and 14 involved MI [33,40,41,42,43,45,48,49,51,56,57,58,62]. In addition, there were 26 studies on Caucasians [23,24,25,27,30,38,39,40,41,42,43,44,45,47,48,50,51,53,56,57,58,60,62,63,64] and 19 studies on Asians [26,28,29,31,32,33,34,35,36,37,46,49,52,54,55,59,61,65,66]. Controls of 23 studies were hospital-based [23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,57,58,59,61,63,64,65,66], while those of the other 22 studies were population-based [38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,60,62]. Seven studies did not follow the Hardy-Weinberg equilibrium [23,35,36,40,42,43,58]. In addition, NOS results showed that the average scores were 6.8.

View Article: PubMed Central - PubMed

ABSTRACT

Background: Previous studies have evaluated the associations between the cholesteryl ester transfer protein (CETP) TaqIB polymorphism (rs708272), the risk of developing composite ischemic cardiovascular disease (CVD) and the concentration of high-density lipoprotein cholesterol (HDL-C), but results remain controversial. The objective of this study was to investigate whether a relationship exists between these factors. Methods: We conducted a meta-analysis of available studies to clarify the associations of the CETP TaqIB polymorphism with HDL-C concentration and the composite ischemic CVD risk in both Asians and Caucasians. All statistical analyses were done with Stata 12.0. Results: Through utilization of the Cochrane Library, Embase, PubMed, Web of Science, Springer, China Science and Technology Journal Database, China National Knowledge Infrastructure, Google Scholar, and Baidu Library, a total of 45 studies from 44 papers with 20,866 cases and 21,298 controls were combined showing a significant association between the CETP TaqIB variant and composite ischemic CVD risk. Carriers of allele TaqIB-B1 were found to have a higher risk of composite ischemic CVD than non-carriers: OR = 1.15, 95% CI = 1.09–1.21, p < 0.001. Meanwhile, 28 studies with 23,959 subjects were included in the association between the CETP TaqIB polymorphism and the concentration of HDL-C. Results suggested that carriers of the B1B1 genotype had lower concentrations of HDL-C than those of the B2B2 genotype: SMD = 0.50, 95% CI = 0.36–0.65, p < 0.001. Conclusions: The synthesis of available evidence demonstrates that the CETP TaqIB polymorphism protects against composite ischemic CVD risk and is associated with a higher HDL-C concentration in both Asians and Caucasians.

No MeSH data available.