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Association between Serum Uric Acid and Elevated Alanine Aminotransferase in the General Population

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ABSTRACT

Background: Both the serum uric acid (SUA) level and elevated alanine aminotransferase (ALT) are related to metabolic syndrome. However, the association between SUA and elevated ALT has not been elucidated in the general population. The objective of this study was to investigate the association between SUA and elevated ALT in the general population of China; Methods: A total of 11,572 adults (≥35 years of age) participated in this survey. Elevated ALT was defined as >40 U/L. SUA ≥ 7.0 mg/dL in males or ≥6.0 mg/dL in females was defined as hyperuricemia. SUA within the reference range was divided into quartiles, and its associations with elevated ALT were evaluated by logistic regressions; Results: A total of 7.4% participants had elevated ALT. The prevalence of hyperuricemia was 14.9% in males and 7.3% in females. There was a significantly positive dose-response association between SUA levels and the prevalence of elevated ALT. After adjusting for potential confounders, a positive relationship for elevated ALT was observed in subjects with hyperuricemia (odds ratio [OR]: 2.032, 95% confidence interval [CI]: 1.443–2.861 for men; OR: 2.045, 95% CI: 1.221–3.425 for women, both p < 0.05). Within the reference range, the association between SUA and elevated ALT persisted in the fourth quartile (OR: 1.467, 95% CI: 1.063–2.025 for men; OR: 1.721, 95% CI: 1.146–2.585 for women, both p < 0.05); Conclusions: Our results indicated that an increased SUA level, even within the reference range, was independently associated with elevated ALT in Chinese adults.

No MeSH data available.


Multivariate analysis of the independent association between serum uric acid and elevated serum ALT by gender (A) for men and (B) for women. The model is adjusted for the same variables as in model 2 in Table 3.
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ijerph-13-00841-f002: Multivariate analysis of the independent association between serum uric acid and elevated serum ALT by gender (A) for men and (B) for women. The model is adjusted for the same variables as in model 2 in Table 3.

Mentions: Table 3 presents the multiple logistic regression analysis for elevated serum ALT. After adjusting for age and race in both genders (model 1), the logistic regression models showed that, comparing the highest SUA quartile and hyperuricemia with the lowest SUA quartile, SUA had a significant association with the elevated serum ALT. After further adjustment for WC, BMI, smoking, drinking, education level, physical activity, family income, history of CVD, BP, FPG and lipid profiles (model 2), we found that hyperuricemia was positively associated with elevated ALT (OR 2.032, 95% CI 1.443–2.861 for men; OR 2.045, 95% CI 1.221–3.425 for women). Subjects with hyperuricemia tended to exhibit a higher likelihood of having elevated ALT. Even within the reference range, subjects in the highest SUA quartile had a 1.467 times (for men) and 1.721 times (for women) higher risk of elevated ALT than those in the lowest SUA quartile (p < 0.05). The adjusted ORs and 95% CIs in all of the SUA categories for elevated ALT are shown in Figure 2.


Association between Serum Uric Acid and Elevated Alanine Aminotransferase in the General Population
Multivariate analysis of the independent association between serum uric acid and elevated serum ALT by gender (A) for men and (B) for women. The model is adjusted for the same variables as in model 2 in Table 3.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5036674&req=5

ijerph-13-00841-f002: Multivariate analysis of the independent association between serum uric acid and elevated serum ALT by gender (A) for men and (B) for women. The model is adjusted for the same variables as in model 2 in Table 3.
Mentions: Table 3 presents the multiple logistic regression analysis for elevated serum ALT. After adjusting for age and race in both genders (model 1), the logistic regression models showed that, comparing the highest SUA quartile and hyperuricemia with the lowest SUA quartile, SUA had a significant association with the elevated serum ALT. After further adjustment for WC, BMI, smoking, drinking, education level, physical activity, family income, history of CVD, BP, FPG and lipid profiles (model 2), we found that hyperuricemia was positively associated with elevated ALT (OR 2.032, 95% CI 1.443–2.861 for men; OR 2.045, 95% CI 1.221–3.425 for women). Subjects with hyperuricemia tended to exhibit a higher likelihood of having elevated ALT. Even within the reference range, subjects in the highest SUA quartile had a 1.467 times (for men) and 1.721 times (for women) higher risk of elevated ALT than those in the lowest SUA quartile (p < 0.05). The adjusted ORs and 95% CIs in all of the SUA categories for elevated ALT are shown in Figure 2.

View Article: PubMed Central - PubMed

ABSTRACT

Background: Both the serum uric acid (SUA) level and elevated alanine aminotransferase (ALT) are related to metabolic syndrome. However, the association between SUA and elevated ALT has not been elucidated in the general population. The objective of this study was to investigate the association between SUA and elevated ALT in the general population of China; Methods: A total of 11,572 adults (&ge;35 years of age) participated in this survey. Elevated ALT was defined as &gt;40 U/L. SUA &ge; 7.0 mg/dL in males or &ge;6.0 mg/dL in females was defined as hyperuricemia. SUA within the reference range was divided into quartiles, and its associations with elevated ALT were evaluated by logistic regressions; Results: A total of 7.4% participants had elevated ALT. The prevalence of hyperuricemia was 14.9% in males and 7.3% in females. There was a significantly positive dose-response association between SUA levels and the prevalence of elevated ALT. After adjusting for potential confounders, a positive relationship for elevated ALT was observed in subjects with hyperuricemia (odds ratio [OR]: 2.032, 95% confidence interval [CI]: 1.443&ndash;2.861 for men; OR: 2.045, 95% CI: 1.221&ndash;3.425 for women, both p &lt; 0.05). Within the reference range, the association between SUA and elevated ALT persisted in the fourth quartile (OR: 1.467, 95% CI: 1.063&ndash;2.025 for men; OR: 1.721, 95% CI: 1.146&ndash;2.585 for women, both p &lt; 0.05); Conclusions: Our results indicated that an increased SUA level, even within the reference range, was independently associated with elevated ALT in Chinese adults.

No MeSH data available.