Limits...
Association between Serum Uric Acid and Elevated Alanine Aminotransferase in the General Population

View Article: PubMed Central - PubMed

ABSTRACT

Background: Both the serum uric acid (SUA) level and elevated alanine aminotransferase (ALT) are related to metabolic syndrome. However, the association between SUA and elevated ALT has not been elucidated in the general population. The objective of this study was to investigate the association between SUA and elevated ALT in the general population of China; Methods: A total of 11,572 adults (≥35 years of age) participated in this survey. Elevated ALT was defined as >40 U/L. SUA ≥ 7.0 mg/dL in males or ≥6.0 mg/dL in females was defined as hyperuricemia. SUA within the reference range was divided into quartiles, and its associations with elevated ALT were evaluated by logistic regressions; Results: A total of 7.4% participants had elevated ALT. The prevalence of hyperuricemia was 14.9% in males and 7.3% in females. There was a significantly positive dose-response association between SUA levels and the prevalence of elevated ALT. After adjusting for potential confounders, a positive relationship for elevated ALT was observed in subjects with hyperuricemia (odds ratio [OR]: 2.032, 95% confidence interval [CI]: 1.443–2.861 for men; OR: 2.045, 95% CI: 1.221–3.425 for women, both p < 0.05). Within the reference range, the association between SUA and elevated ALT persisted in the fourth quartile (OR: 1.467, 95% CI: 1.063–2.025 for men; OR: 1.721, 95% CI: 1.146–2.585 for women, both p < 0.05); Conclusions: Our results indicated that an increased SUA level, even within the reference range, was independently associated with elevated ALT in Chinese adults.

No MeSH data available.


The proportion of adults with elevated ALT categorized by the uric acid level in both genders.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC5036674&req=5

ijerph-13-00841-f001: The proportion of adults with elevated ALT categorized by the uric acid level in both genders.

Mentions: As shown in Figure 1, among both men and women, the prevalence of elevated ALT increased with an increment in the SUA level (p < 0.001). The proportions of elevated ALT from quartiles 1–4 of normal SUA to hyperuricemia were 6.5%, 7.5%, 8.2%, 12.8% and 20.4% for men, 2.7%, 2.8%, 5.2%, 6.9% and 9.5% for women, respectively. Among subjects in the fourth quartile and the hyperuricemia group, approximately 33.2% men and 16.4% women had elevated ALT. In addition, data showed that men had a higher prevalence of elevated ALT than women in all of the SUA categories.


Association between Serum Uric Acid and Elevated Alanine Aminotransferase in the General Population
The proportion of adults with elevated ALT categorized by the uric acid level in both genders.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5036674&req=5

ijerph-13-00841-f001: The proportion of adults with elevated ALT categorized by the uric acid level in both genders.
Mentions: As shown in Figure 1, among both men and women, the prevalence of elevated ALT increased with an increment in the SUA level (p < 0.001). The proportions of elevated ALT from quartiles 1–4 of normal SUA to hyperuricemia were 6.5%, 7.5%, 8.2%, 12.8% and 20.4% for men, 2.7%, 2.8%, 5.2%, 6.9% and 9.5% for women, respectively. Among subjects in the fourth quartile and the hyperuricemia group, approximately 33.2% men and 16.4% women had elevated ALT. In addition, data showed that men had a higher prevalence of elevated ALT than women in all of the SUA categories.

View Article: PubMed Central - PubMed

ABSTRACT

Background: Both the serum uric acid (SUA) level and elevated alanine aminotransferase (ALT) are related to metabolic syndrome. However, the association between SUA and elevated ALT has not been elucidated in the general population. The objective of this study was to investigate the association between SUA and elevated ALT in the general population of China; Methods: A total of 11,572 adults (&ge;35 years of age) participated in this survey. Elevated ALT was defined as &gt;40 U/L. SUA &ge; 7.0 mg/dL in males or &ge;6.0 mg/dL in females was defined as hyperuricemia. SUA within the reference range was divided into quartiles, and its associations with elevated ALT were evaluated by logistic regressions; Results: A total of 7.4% participants had elevated ALT. The prevalence of hyperuricemia was 14.9% in males and 7.3% in females. There was a significantly positive dose-response association between SUA levels and the prevalence of elevated ALT. After adjusting for potential confounders, a positive relationship for elevated ALT was observed in subjects with hyperuricemia (odds ratio [OR]: 2.032, 95% confidence interval [CI]: 1.443&ndash;2.861 for men; OR: 2.045, 95% CI: 1.221&ndash;3.425 for women, both p &lt; 0.05). Within the reference range, the association between SUA and elevated ALT persisted in the fourth quartile (OR: 1.467, 95% CI: 1.063&ndash;2.025 for men; OR: 1.721, 95% CI: 1.146&ndash;2.585 for women, both p &lt; 0.05); Conclusions: Our results indicated that an increased SUA level, even within the reference range, was independently associated with elevated ALT in Chinese adults.

No MeSH data available.