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Natively unfolded proteins: An overview

View Article: PubMed Central - PubMed

ABSTRACT

Proteins with wholly or partly denatured structures in vivo are called intrinsically disordered or natively unfolded proteins (NUPs). Functional importance of NUPs was revealed by NMR studies as first reviewed by P. Wright in 1999. Since then, computational analyses on NUPs have also been intensively carried out to predict that approximately one third of eukaryotic proteins are NUPs. I will start this overview with the question why it took so long to identify NUPs as an important subject of protein science, and then move on to several issues such as, whether or not NUPs are specific to eukaryotes, what a particularly higher fraction of NUPs existing in the nucleus means, and what evolutionary implications NUPs have.

No MeSH data available.


Comparison of transcription factors from various organisms. Length-wise fractions of structural domains (green), ID regions (red) and unassigned regions (blank) were estimated from a large number of transcription factors of each organism indicated. Note the clear difference between the ID fractions of eukaryote (human, fruit fly, yeast, and Arabidopsis) and prokaryote (E. coli).
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f1-5_53: Comparison of transcription factors from various organisms. Length-wise fractions of structural domains (green), ID regions (red) and unassigned regions (blank) were estimated from a large number of transcription factors of each organism indicated. Note the clear difference between the ID fractions of eukaryote (human, fruit fly, yeast, and Arabidopsis) and prokaryote (E. coli).

Mentions: Due to the high fraction of ID regions and the functional importance, human transcription factors can be regarded as typical NUPs. Although such characteristics of transcription factors are shared by eukaryotes in general, they are rare in prokaryotes (Fig. 1): prokaryotic transcription factors almost completely lack ID regions19.


Natively unfolded proteins: An overview
Comparison of transcription factors from various organisms. Length-wise fractions of structural domains (green), ID regions (red) and unassigned regions (blank) were estimated from a large number of transcription factors of each organism indicated. Note the clear difference between the ID fractions of eukaryote (human, fruit fly, yeast, and Arabidopsis) and prokaryote (E. coli).
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC5036634&req=5

f1-5_53: Comparison of transcription factors from various organisms. Length-wise fractions of structural domains (green), ID regions (red) and unassigned regions (blank) were estimated from a large number of transcription factors of each organism indicated. Note the clear difference between the ID fractions of eukaryote (human, fruit fly, yeast, and Arabidopsis) and prokaryote (E. coli).
Mentions: Due to the high fraction of ID regions and the functional importance, human transcription factors can be regarded as typical NUPs. Although such characteristics of transcription factors are shared by eukaryotes in general, they are rare in prokaryotes (Fig. 1): prokaryotic transcription factors almost completely lack ID regions19.

View Article: PubMed Central - PubMed

ABSTRACT

Proteins with wholly or partly denatured structures in vivo are called intrinsically disordered or natively unfolded proteins (NUPs). Functional importance of NUPs was revealed by NMR studies as first reviewed by P. Wright in 1999. Since then, computational analyses on NUPs have also been intensively carried out to predict that approximately one third of eukaryotic proteins are NUPs. I will start this overview with the question why it took so long to identify NUPs as an important subject of protein science, and then move on to several issues such as, whether or not NUPs are specific to eukaryotes, what a particularly higher fraction of NUPs existing in the nucleus means, and what evolutionary implications NUPs have.

No MeSH data available.