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HINT: a database of annotated protein-protein interactions and their homologs

View Article: PubMed Central - PubMed

ABSTRACT

Despite the abundance of protein-protein interaction databases currently available online, a source that identifies and lists similar interactions in different species is lacking. The Homologous Interactions (HINT) database is such a collection of protein-protein interactions and their homologs in one or more species. The interactions and their homologs are annotated with Eukaryotic Cluster of Orthologous Groups (KOG) IDs, InterPro domains, Gene Ontology (GO) terminology and Protein Data Bank (PDB) structures. HINT is available as an interactive Web server at http://helix.protein.osaka-u.ac.jp/hint/.

No MeSH data available.


Homologous interactions — Proteins P1, P2, P3 are the sequence homologs of protein P. Similarly, proteins Q1, Q2 are the sequence homologs of protein Q. Interactions P1–Q2 and P2–Q1 are homologous to the interaction P–Q.
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f1-1_21: Homologous interactions — Proteins P1, P2, P3 are the sequence homologs of protein P. Similarly, proteins Q1, Q2 are the sequence homologs of protein Q. Interactions P1–Q2 and P2–Q1 are homologous to the interaction P–Q.

Mentions: Two interactions are considered homologous if the interacting proteins of one interaction are homologous to the interacting proteins for the other interaction (Fig. 1). Homologous interactions include, but are not limited to, orthologous interactions (similar interactions found in different species) and paralogous interactions (similar interactions in the same species).


HINT: a database of annotated protein-protein interactions and their homologs
Homologous interactions — Proteins P1, P2, P3 are the sequence homologs of protein P. Similarly, proteins Q1, Q2 are the sequence homologs of protein Q. Interactions P1–Q2 and P2–Q1 are homologous to the interaction P–Q.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC5036632&req=5

f1-1_21: Homologous interactions — Proteins P1, P2, P3 are the sequence homologs of protein P. Similarly, proteins Q1, Q2 are the sequence homologs of protein Q. Interactions P1–Q2 and P2–Q1 are homologous to the interaction P–Q.
Mentions: Two interactions are considered homologous if the interacting proteins of one interaction are homologous to the interacting proteins for the other interaction (Fig. 1). Homologous interactions include, but are not limited to, orthologous interactions (similar interactions found in different species) and paralogous interactions (similar interactions in the same species).

View Article: PubMed Central - PubMed

ABSTRACT

Despite the abundance of protein-protein interaction databases currently available online, a source that identifies and lists similar interactions in different species is lacking. The Homologous Interactions (HINT) database is such a collection of protein-protein interactions and their homologs in one or more species. The interactions and their homologs are annotated with Eukaryotic Cluster of Orthologous Groups (KOG) IDs, InterPro domains, Gene Ontology (GO) terminology and Protein Data Bank (PDB) structures. HINT is available as an interactive Web server at http://helix.protein.osaka-u.ac.jp/hint/.

No MeSH data available.