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Apparent diffusion coefficient values detected by diffusion-weighted imaging in the prognosis of patients with locally advanced esophageal squamous cell carcinoma receiving chemoradiation

View Article: PubMed Central - PubMed

ABSTRACT

Purpose: Previous studies have demonstrated that apparent diffusion coefficient (ADC) values measured by magnetic resonance imaging have prognostic value in patients with esophageal squamous cell carcinoma (ESCC). However, the role of ADC needs to be validated in a cohort of Chinese ESCC patients. This study assessed the role of ADC in predicting the outcome of patients with ESCC treated only by chemoradiation in the People’s Republic of China.

Patients and methods: Seventy-three patients with local advanced ESCC were retrospectively analyzed in this study; none of the patients underwent surgery before or after chemoradiation. The ADC values of the primary tumors were determined by magnetic resonance imaging. The ADC values were then correlated with clinicopathological and other radiological parameters. Survival analysis was carried out to determine if ADC had an impact on survival of these patients.

Results: The median ADC value of the esophageal cancer tissue was 1.256*10−3 mm2/sec (range: 0.657–2.354*10−3 mm2/sec, interquartile range 0.606*10−3 mm2/sec). No clinicopathological or radiological parameters were associated with the ADC values except the sites of tumor tissues. ADC <1.076*10−3 mm2/sec predicted significantly worse survival in patients with ESCC (12.9 months vs undefined, P=0.0108).

Conclusion: The ADC value is a potent prognostic factor which can be used to predict the outcome of patients with ESCC treated only by chemoradiation.

No MeSH data available.


A 74-year-old female with a lesion involving the middle third of the esophagus.Notes: The T2 image (A) showed an irregular wall thickening (arrow), native DWI images at b-values of 0 (B) and 800 sec/mm2 (C) showed hyperintense signal and ADC map (D) showed hypointense signal. The average ADC value was 1.019*10−3 mm2/s.Abbreviations: ADC, apparent diffusion coefficient; DWI, diffusion-weighted imaging.
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f1-ott-9-5791: A 74-year-old female with a lesion involving the middle third of the esophagus.Notes: The T2 image (A) showed an irregular wall thickening (arrow), native DWI images at b-values of 0 (B) and 800 sec/mm2 (C) showed hyperintense signal and ADC map (D) showed hypointense signal. The average ADC value was 1.019*10−3 mm2/s.Abbreviations: ADC, apparent diffusion coefficient; DWI, diffusion-weighted imaging.

Mentions: Measurements were obtained on the ADC maps that were reconstructed by using the b-value of 0 and 800 sec/mm2. The tumor tissue is characterized by high-signal intensity on DWI and low-signal intensity on ADC maps (Figure 1). On the ADC images, three region of interests (ROIs) (area range, 22.42–41.21 mm2; mean, 32.41 mm2) were manually drawn on the solid sections of the tumors. Referring to T2-weighted image, visually identified vessels and necrotic areas were avoided. The measured ADC values from three ROIs were then averaged to a mean value for future statistical analysis.


Apparent diffusion coefficient values detected by diffusion-weighted imaging in the prognosis of patients with locally advanced esophageal squamous cell carcinoma receiving chemoradiation
A 74-year-old female with a lesion involving the middle third of the esophagus.Notes: The T2 image (A) showed an irregular wall thickening (arrow), native DWI images at b-values of 0 (B) and 800 sec/mm2 (C) showed hyperintense signal and ADC map (D) showed hypointense signal. The average ADC value was 1.019*10−3 mm2/s.Abbreviations: ADC, apparent diffusion coefficient; DWI, diffusion-weighted imaging.
© Copyright Policy
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5036604&req=5

f1-ott-9-5791: A 74-year-old female with a lesion involving the middle third of the esophagus.Notes: The T2 image (A) showed an irregular wall thickening (arrow), native DWI images at b-values of 0 (B) and 800 sec/mm2 (C) showed hyperintense signal and ADC map (D) showed hypointense signal. The average ADC value was 1.019*10−3 mm2/s.Abbreviations: ADC, apparent diffusion coefficient; DWI, diffusion-weighted imaging.
Mentions: Measurements were obtained on the ADC maps that were reconstructed by using the b-value of 0 and 800 sec/mm2. The tumor tissue is characterized by high-signal intensity on DWI and low-signal intensity on ADC maps (Figure 1). On the ADC images, three region of interests (ROIs) (area range, 22.42–41.21 mm2; mean, 32.41 mm2) were manually drawn on the solid sections of the tumors. Referring to T2-weighted image, visually identified vessels and necrotic areas were avoided. The measured ADC values from three ROIs were then averaged to a mean value for future statistical analysis.

View Article: PubMed Central - PubMed

ABSTRACT

Purpose: Previous studies have demonstrated that apparent diffusion coefficient (ADC) values measured by magnetic resonance imaging have prognostic value in patients with esophageal squamous cell carcinoma (ESCC). However, the role of ADC needs to be validated in a cohort of Chinese ESCC patients. This study assessed the role of ADC in predicting the outcome of patients with ESCC treated only by chemoradiation in the People’s Republic of China.

Patients and methods: Seventy-three patients with local advanced ESCC were retrospectively analyzed in this study; none of the patients underwent surgery before or after chemoradiation. The ADC values of the primary tumors were determined by magnetic resonance imaging. The ADC values were then correlated with clinicopathological and other radiological parameters. Survival analysis was carried out to determine if ADC had an impact on survival of these patients.

Results: The median ADC value of the esophageal cancer tissue was 1.256*10−3 mm2/sec (range: 0.657–2.354*10−3 mm2/sec, interquartile range 0.606*10−3 mm2/sec). No clinicopathological or radiological parameters were associated with the ADC values except the sites of tumor tissues. ADC <1.076*10−3 mm2/sec predicted significantly worse survival in patients with ESCC (12.9 months vs undefined, P=0.0108).

Conclusion: The ADC value is a potent prognostic factor which can be used to predict the outcome of patients with ESCC treated only by chemoradiation.

No MeSH data available.