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Increased frontal electroencephalogram theta amplitude in patients with anorexia nervosa compared to healthy controls

View Article: PubMed Central - PubMed

ABSTRACT

Objective: To conduct a blind study of quantitative electroencephalogram-band amplitudes in patients with anorexia nervosa (AN) and healthy controls.

Methods: Twenty-one patients with AN and 24 controls were examined with eyes-closed 16-channel electroencephalogram. Main variables were absolute alpha, theta, and delta amplitudes in frontal, temporal, and posterior regions.

Results: There were no significant differences between the AN patients and controls regarding absolute regional band amplitudes in μV. Borderline significance was found for anterior theta (P=0.051). Significantly increased left and right frontal electrode theta amplitude was found in AN patients (F3, P=0.014; F4, P=0.038) compared to controls. Significant differences were also observed for secondary variables: lower values for relative parietooccipital delta and frontocentral alpha activity among AN patients than among controls.

Conclusion: We observed slight excess frontal theta and lower relative alpha and delta amplitudes among AN patients than among controls. This pattern is possibly related to a slight frontal lobe dysfunction in AN, or it may reflect increased attention/vigilance or another state-related change in patients with AN compared to healthy controls.

No MeSH data available.


Related in: MedlinePlus

Frontal theta amplitude at F3 (left box) and F4 (right box) in anorexia and control subjects.Notes: Differences were significant in the left (F3; P=0.014) and right (F4; P=0.038) frontal areas. *Outlier.Abbreviations: AN, anorexia nervosa group; CO, healthy control group.
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f1-ndt-12-2419: Frontal theta amplitude at F3 (left box) and F4 (right box) in anorexia and control subjects.Notes: Differences were significant in the left (F3; P=0.014) and right (F4; P=0.038) frontal areas. *Outlier.Abbreviations: AN, anorexia nervosa group; CO, healthy control group.

Mentions: No epileptiform EEG activity was observed. Occipital alpha peak frequency was mean (standard deviation [SD]) =10.55 (0.93) Hz in AN and 10.25 (0.85) Hz in controls (Student’s t-test, P=0.26). Regarding the main qEEG variables (absolute amplitude), no difference in delta or alpha bands was observed. A strong trend toward increased regional frontocentral theta (P=0.051) was observed in AN patients. AN subjects had significantly increased theta activity at both the left (F3; P=0.014) and right (F4; P=0.038) frontal electrodes (Figure 1). This difference was preserved when patients on antipsychotics were excluded (P=0.012 and 0.022, respectively).


Increased frontal electroencephalogram theta amplitude in patients with anorexia nervosa compared to healthy controls
Frontal theta amplitude at F3 (left box) and F4 (right box) in anorexia and control subjects.Notes: Differences were significant in the left (F3; P=0.014) and right (F4; P=0.038) frontal areas. *Outlier.Abbreviations: AN, anorexia nervosa group; CO, healthy control group.
© Copyright Policy
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5036600&req=5

f1-ndt-12-2419: Frontal theta amplitude at F3 (left box) and F4 (right box) in anorexia and control subjects.Notes: Differences were significant in the left (F3; P=0.014) and right (F4; P=0.038) frontal areas. *Outlier.Abbreviations: AN, anorexia nervosa group; CO, healthy control group.
Mentions: No epileptiform EEG activity was observed. Occipital alpha peak frequency was mean (standard deviation [SD]) =10.55 (0.93) Hz in AN and 10.25 (0.85) Hz in controls (Student’s t-test, P=0.26). Regarding the main qEEG variables (absolute amplitude), no difference in delta or alpha bands was observed. A strong trend toward increased regional frontocentral theta (P=0.051) was observed in AN patients. AN subjects had significantly increased theta activity at both the left (F3; P=0.014) and right (F4; P=0.038) frontal electrodes (Figure 1). This difference was preserved when patients on antipsychotics were excluded (P=0.012 and 0.022, respectively).

View Article: PubMed Central - PubMed

ABSTRACT

Objective: To conduct a blind study of quantitative electroencephalogram-band amplitudes in patients with anorexia nervosa (AN) and healthy controls.

Methods: Twenty-one patients with AN and 24 controls were examined with eyes-closed 16-channel electroencephalogram. Main variables were absolute alpha, theta, and delta amplitudes in frontal, temporal, and posterior regions.

Results: There were no significant differences between the AN patients and controls regarding absolute regional band amplitudes in μV. Borderline significance was found for anterior theta (P=0.051). Significantly increased left and right frontal electrode theta amplitude was found in AN patients (F3, P=0.014; F4, P=0.038) compared to controls. Significant differences were also observed for secondary variables: lower values for relative parietooccipital delta and frontocentral alpha activity among AN patients than among controls.

Conclusion: We observed slight excess frontal theta and lower relative alpha and delta amplitudes among AN patients than among controls. This pattern is possibly related to a slight frontal lobe dysfunction in AN, or it may reflect increased attention/vigilance or another state-related change in patients with AN compared to healthy controls.

No MeSH data available.


Related in: MedlinePlus