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Effect of low dose of intrathecal pethidine on the incidence and intensity of shivering during cesarean section under spinal anesthesia: a randomized, placebo-controlled, double-blind clinical trial

View Article: PubMed Central - PubMed

ABSTRACT

Introduction: Shivering is among the unpleasant and potentially harmful side effects of spinal anesthesia. The aim of this randomized double-blind clinical trial was to compare the antishivering effect of two different doses of intrathecal pethidine on the incidence and intensity of shivering and other side effects in patients who underwent cesarean section.

Methods: In this study, 150 parturient females scheduled for nonemergent cesarean section were randomly allocated to three groups. Spinal anesthesia was performed with 0.5% hyperbaric bupivacaine (12.5 mg), plus 0.5 mL of 0.9% saline in the standard group (S group), and the same dose of bupivacaine with 5 mg (P5 group) or 10 mg of pethidine (P10 group). Demographic and surgical data, incidence and intensity of shivering (primary outcome), hemodynamic indices, forehead and core temperatures, maximum sensory level, Apgar scores, and adverse events were evaluated by a blinded observer.

Results: There were no significant differences between the three study groups regarding the demographic and surgical data, hemodynamic indices, core temperatures, and maximum sensory level (P>0.05). The incidence and intensity of shivering were significantly less in the P5 and P10 groups (P<0.001) when compared with the S group. There were no significant differences between groups for secondary outcomes, except pruritus, which was more common in the P5 and P10 groups when compared with the S group (P=0.01).

Conclusion: Low dose of intrathecal pethidine is safe, and can decrease the incidence and intensity of shivering during cesarean section, without having major side effects.

No MeSH data available.


Group randomization according to CONSORT 2010.Abbreviation: CONSORT, Consolidated Standards of Reporting Trials.
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f1-dddt-10-3005: Group randomization according to CONSORT 2010.Abbreviation: CONSORT, Consolidated Standards of Reporting Trials.

Mentions: From 184 participants, 150 participants met inclusion criteria and they were randomized by an anesthetic nurse who was not involved in the outcome evaluation. The flow diagram of randomized patients is shown in Figure 1. There was no significant difference according to the age, duration of surgery, preoperative hemoglobin, and hematocrit levels between the three groups (Table 1).


Effect of low dose of intrathecal pethidine on the incidence and intensity of shivering during cesarean section under spinal anesthesia: a randomized, placebo-controlled, double-blind clinical trial
Group randomization according to CONSORT 2010.Abbreviation: CONSORT, Consolidated Standards of Reporting Trials.
© Copyright Policy
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5036596&req=5

f1-dddt-10-3005: Group randomization according to CONSORT 2010.Abbreviation: CONSORT, Consolidated Standards of Reporting Trials.
Mentions: From 184 participants, 150 participants met inclusion criteria and they were randomized by an anesthetic nurse who was not involved in the outcome evaluation. The flow diagram of randomized patients is shown in Figure 1. There was no significant difference according to the age, duration of surgery, preoperative hemoglobin, and hematocrit levels between the three groups (Table 1).

View Article: PubMed Central - PubMed

ABSTRACT

Introduction: Shivering is among the unpleasant and potentially harmful side effects of spinal anesthesia. The aim of this randomized double-blind clinical trial was to compare the antishivering effect of two different doses of intrathecal pethidine on the incidence and intensity of shivering and other side effects in patients who underwent cesarean section.

Methods: In this study, 150 parturient females scheduled for nonemergent cesarean section were randomly allocated to three groups. Spinal anesthesia was performed with 0.5% hyperbaric bupivacaine (12.5 mg), plus 0.5 mL of 0.9% saline in the standard group (S group), and the same dose of bupivacaine with 5 mg (P5 group) or 10 mg of pethidine (P10 group). Demographic and surgical data, incidence and intensity of shivering (primary outcome), hemodynamic indices, forehead and core temperatures, maximum sensory level, Apgar scores, and adverse events were evaluated by a blinded observer.

Results: There were no significant differences between the three study groups regarding the demographic and surgical data, hemodynamic indices, core temperatures, and maximum sensory level (P>0.05). The incidence and intensity of shivering were significantly less in the P5 and P10 groups (P<0.001) when compared with the S group. There were no significant differences between groups for secondary outcomes, except pruritus, which was more common in the P5 and P10 groups when compared with the S group (P=0.01).

Conclusion: Low dose of intrathecal pethidine is safe, and can decrease the incidence and intensity of shivering during cesarean section, without having major side effects.

No MeSH data available.