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Evaluation of c-Met, HGF, and HER-2 expressions in gastric carcinoma and their association with other clinicopathological factors

View Article: PubMed Central - PubMed

ABSTRACT

Background: Met and HER-2 are proto-oncogenes encoding receptor tyrosine kinase c-Met and HER-2, respectively. Hepatocyte growth factor (HGF) is a ligand of c-Met. The frequency of c-Met, HGF, and HER-2 expressions in gastric cancer and their association with other clinicopathological factors have not been fully understood.

Patients and methods: Patients with stage 1–4 disease were analyzed. Expressions of c-Met, HGF, and HER-2 were examined using immunohistochemistry.

Results: A total of 143 patients, 97 males and 46 females, were included. C-Met scores were 3(+) in 31.5%, 2(+) in 27.3%, and 1(+) in 10.5% of the patients. There was no statistically significant difference in age, sex, tumor location, differentiation, Lauren classification, TNM staging, presence of distant metastasis, depth of tumor invasion (T), lymphovascular invasion, and survival between c-Met subgroups. Overall HGF positivity was 20.6%. HER-2 scores were 3(+) in 9.1%, 2(+) in 9.8%, and 1(+) in 16.1% of the patients. HER-2 overexpression was associated with better differentiation, intestinal subtype, and advanced stage. C-Met overexpressions were 84.6% in the HER-2-overexpression-positive group and 56.2% in the HER-2-overexpression-negative group. There were no statistically significant differences in survival between the high c-Met-expression-positive and -negative stage 3 and stage 4 patients and between the HGF-positive and -negative groups. The mean survival was 11.6±6.3 months in the HER-2-overexpression-positive stage 4 group and 11.9±6.8 months in the HER-2-overexpression-negative stage 4 group. There were no statistically significant differences in survival between the two groups.

Conclusion: c-Met was not associated with any prognostic factors in gastric cancer. HER-2 was associated with better differentiation, intestinal subtype, advanced stage, and c-Met overexpression.

No MeSH data available.


Related in: MedlinePlus

(A and B) Immunohistochemical staining using c-Met antibody showing 3(+) reaction in gastric cancer cells (×40).
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f2-ott-9-5809: (A and B) Immunohistochemical staining using c-Met antibody showing 3(+) reaction in gastric cancer cells (×40).

Mentions: Of the 143 gastric carcinoma tissue samples, 44 (30.8%) were scored as 0, 15 (10.5%) as 1(+), 39 (27.2%) as 2(+), and 45 (31.5%) as 3(+). The overexpression (2+ and 3+) rate was 58.7% (84/143; Figure 2). The c-Met status was not associated with the sex, tumor location, tumor differentiation, Lauren classification, TNM stage (by seventh UICC/AJCC), presence or absence of distant metastases, depth of tumor invasion (T), and lymphovascular invasion (P=0.462, P=0.595, P=0.636, P=0.387, P=0.823, P=0.823, P=0.820, and P=0.678). HER-2 overexpression was 13.1% in the c-Met-overexpression-positive group and 3.4% in the c-Met-overexpression-negative group. HGF expression was 21.0% in the c-Met-overexpression-positive group. Only one patient had peritoneal carcinomatosis in both HGF/c-Met-positive groups. The median survival was 19.6±7.4 months in the c-Met-overexpression-positive group and 23.3±3.0 months in the c-Met-overexpression-negative group (Tables 2 and 3). There were no statistically significant differences in survival between the two groups (P=0.711).


Evaluation of c-Met, HGF, and HER-2 expressions in gastric carcinoma and their association with other clinicopathological factors
(A and B) Immunohistochemical staining using c-Met antibody showing 3(+) reaction in gastric cancer cells (×40).
© Copyright Policy
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5036569&req=5

f2-ott-9-5809: (A and B) Immunohistochemical staining using c-Met antibody showing 3(+) reaction in gastric cancer cells (×40).
Mentions: Of the 143 gastric carcinoma tissue samples, 44 (30.8%) were scored as 0, 15 (10.5%) as 1(+), 39 (27.2%) as 2(+), and 45 (31.5%) as 3(+). The overexpression (2+ and 3+) rate was 58.7% (84/143; Figure 2). The c-Met status was not associated with the sex, tumor location, tumor differentiation, Lauren classification, TNM stage (by seventh UICC/AJCC), presence or absence of distant metastases, depth of tumor invasion (T), and lymphovascular invasion (P=0.462, P=0.595, P=0.636, P=0.387, P=0.823, P=0.823, P=0.820, and P=0.678). HER-2 overexpression was 13.1% in the c-Met-overexpression-positive group and 3.4% in the c-Met-overexpression-negative group. HGF expression was 21.0% in the c-Met-overexpression-positive group. Only one patient had peritoneal carcinomatosis in both HGF/c-Met-positive groups. The median survival was 19.6±7.4 months in the c-Met-overexpression-positive group and 23.3±3.0 months in the c-Met-overexpression-negative group (Tables 2 and 3). There were no statistically significant differences in survival between the two groups (P=0.711).

View Article: PubMed Central - PubMed

ABSTRACT

Background: Met and HER-2 are proto-oncogenes encoding receptor tyrosine kinase c-Met and HER-2, respectively. Hepatocyte growth factor (HGF) is a ligand of c-Met. The frequency of c-Met, HGF, and HER-2 expressions in gastric cancer and their association with other clinicopathological factors have not been fully understood.

Patients and methods: Patients with stage 1–4 disease were analyzed. Expressions of c-Met, HGF, and HER-2 were examined using immunohistochemistry.

Results: A total of 143 patients, 97 males and 46 females, were included. C-Met scores were 3(+) in 31.5%, 2(+) in 27.3%, and 1(+) in 10.5% of the patients. There was no statistically significant difference in age, sex, tumor location, differentiation, Lauren classification, TNM staging, presence of distant metastasis, depth of tumor invasion (T), lymphovascular invasion, and survival between c-Met subgroups. Overall HGF positivity was 20.6%. HER-2 scores were 3(+) in 9.1%, 2(+) in 9.8%, and 1(+) in 16.1% of the patients. HER-2 overexpression was associated with better differentiation, intestinal subtype, and advanced stage. C-Met overexpressions were 84.6% in the HER-2-overexpression-positive group and 56.2% in the HER-2-overexpression-negative group. There were no statistically significant differences in survival between the high c-Met-expression-positive and -negative stage 3 and stage 4 patients and between the HGF-positive and -negative groups. The mean survival was 11.6±6.3 months in the HER-2-overexpression-positive stage 4 group and 11.9±6.8 months in the HER-2-overexpression-negative stage 4 group. There were no statistically significant differences in survival between the two groups.

Conclusion: c-Met was not associated with any prognostic factors in gastric cancer. HER-2 was associated with better differentiation, intestinal subtype, advanced stage, and c-Met overexpression.

No MeSH data available.


Related in: MedlinePlus