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Chronic hypersensitivity pneumonitis

View Article: PubMed Central - PubMed

ABSTRACT

Hypersensitivity pneumonitis (HSP) is a common interstitial lung disease resulting from inhalation of a large variety of antigens by susceptible individuals. The disease is best classified as acute and chronic. Chronic HSP can be fibrosing or not. Fibrotic HSP has a large differential diagnosis and has a worse prognosis. The most common etiologies for HSP are reviewed. Diagnostic criteria are proposed for both chronic forms based on exposure, lung auscultation, lung function tests, HRCT findings, bronchoalveolar lavage, and biopsies. Treatment options are limited, but lung transplantation results in greater survival in comparison to idiopathic pulmonary fibrosis. Randomized trials with new antifibrotic agents are necessary.

No MeSH data available.


Related in: MedlinePlus

Chronic nonfibrotic HSP.Notes: Female, 56 years of age, ex-smoker; dyspnea in the last 7 months. Exposure to molds in the bedroom. FVC =2.31 L (94%); FEV1/FVC =0.87; RV =1.98 L (145%). Inspiratory HRCT without abnormalities. (A) Expiratory images showing several areas of air trapping. (B) Surgical lung biopsy showing cellular bronchiolitis with ill-defined granulomas, (C) focal peribronchiolar lymphocytic interstitial pneumonia, and air trapping. Removed from exposure with reversion of dyspnea and return of residual volume to normal range.Abbreviations: HSP, hypersensitivity pneumonitis; HRCT, high-resolution computed tomography; FVC, forced vital capacity; RV, residual volume.
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f2-jaa-9-171: Chronic nonfibrotic HSP.Notes: Female, 56 years of age, ex-smoker; dyspnea in the last 7 months. Exposure to molds in the bedroom. FVC =2.31 L (94%); FEV1/FVC =0.87; RV =1.98 L (145%). Inspiratory HRCT without abnormalities. (A) Expiratory images showing several areas of air trapping. (B) Surgical lung biopsy showing cellular bronchiolitis with ill-defined granulomas, (C) focal peribronchiolar lymphocytic interstitial pneumonia, and air trapping. Removed from exposure with reversion of dyspnea and return of residual volume to normal range.Abbreviations: HSP, hypersensitivity pneumonitis; HRCT, high-resolution computed tomography; FVC, forced vital capacity; RV, residual volume.

Mentions: Findings on HRCT and lung biopsy in nonfibrosing and fibrosing chronic HP are shown in Figures 2 and 3, respectively.


Chronic hypersensitivity pneumonitis
Chronic nonfibrotic HSP.Notes: Female, 56 years of age, ex-smoker; dyspnea in the last 7 months. Exposure to molds in the bedroom. FVC =2.31 L (94%); FEV1/FVC =0.87; RV =1.98 L (145%). Inspiratory HRCT without abnormalities. (A) Expiratory images showing several areas of air trapping. (B) Surgical lung biopsy showing cellular bronchiolitis with ill-defined granulomas, (C) focal peribronchiolar lymphocytic interstitial pneumonia, and air trapping. Removed from exposure with reversion of dyspnea and return of residual volume to normal range.Abbreviations: HSP, hypersensitivity pneumonitis; HRCT, high-resolution computed tomography; FVC, forced vital capacity; RV, residual volume.
© Copyright Policy
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5036552&req=5

f2-jaa-9-171: Chronic nonfibrotic HSP.Notes: Female, 56 years of age, ex-smoker; dyspnea in the last 7 months. Exposure to molds in the bedroom. FVC =2.31 L (94%); FEV1/FVC =0.87; RV =1.98 L (145%). Inspiratory HRCT without abnormalities. (A) Expiratory images showing several areas of air trapping. (B) Surgical lung biopsy showing cellular bronchiolitis with ill-defined granulomas, (C) focal peribronchiolar lymphocytic interstitial pneumonia, and air trapping. Removed from exposure with reversion of dyspnea and return of residual volume to normal range.Abbreviations: HSP, hypersensitivity pneumonitis; HRCT, high-resolution computed tomography; FVC, forced vital capacity; RV, residual volume.
Mentions: Findings on HRCT and lung biopsy in nonfibrosing and fibrosing chronic HP are shown in Figures 2 and 3, respectively.

View Article: PubMed Central - PubMed

ABSTRACT

Hypersensitivity pneumonitis (HSP) is a common interstitial lung disease resulting from inhalation of a large variety of antigens by susceptible individuals. The disease is best classified as acute and chronic. Chronic HSP can be fibrosing or not. Fibrotic HSP has a large differential diagnosis and has a worse prognosis. The most common etiologies for HSP are reviewed. Diagnostic criteria are proposed for both chronic forms based on exposure, lung auscultation, lung function tests, HRCT findings, bronchoalveolar lavage, and biopsies. Treatment options are limited, but lung transplantation results in greater survival in comparison to idiopathic pulmonary fibrosis. Randomized trials with new antifibrotic agents are necessary.

No MeSH data available.


Related in: MedlinePlus