Limits...
TiO 2 nanotube platforms for smart drug delivery: a review

View Article: PubMed Central - PubMed

ABSTRACT

Titania nanotube (TNT) arrays are recognized as promising materials for localized drug delivery implants because of their excellent properties and facile preparation process. This review highlights the concept of localized drug delivery systems based on TNTs, considering their outstanding biocompatibility in a series of ex vivo and in vivo studies. Considering the safety of TNT implants in the host body, studies of the biocompatibility present significant importance for the clinical application of TNT implants. Toward smart TNT platforms for sustainable drug delivery, several advanced approaches were presented in this review, including controlled release triggered by temperature, light, radiofrequency magnetism, and ultrasonic stimulation. Moreover, TNT implants used in medical therapy have been demonstrated by various examples including dentistry, orthopedic implants, cardiovascular stents, and so on. Finally, a future perspective of TNTs for clinical applications is provided.

No MeSH data available.


Schematic representation of the magnetic stimuli-responsive drug release from TNTs which integrates polymer micelles as drug carriers incorporated with poorly soluble drugs and magnetic nanoparticles loaded at the bottom of the nanotubular structures.Notes: The release is achieved by applying an external magnetic field. Reproduced from Aw MS, Addai-Mensah J, Losic D. Magnetic-responsive delivery of drugcarriers using titania nanotube arrays. J Mater Chem. 2012;22:6561–6563,95 with permission of The Royal Society of Chemistry.Abbreviation: TNT, titania nanotube.
© Copyright Policy
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC5036548&req=5

f8-ijn-11-4819: Schematic representation of the magnetic stimuli-responsive drug release from TNTs which integrates polymer micelles as drug carriers incorporated with poorly soluble drugs and magnetic nanoparticles loaded at the bottom of the nanotubular structures.Notes: The release is achieved by applying an external magnetic field. Reproduced from Aw MS, Addai-Mensah J, Losic D. Magnetic-responsive delivery of drugcarriers using titania nanotube arrays. J Mater Chem. 2012;22:6561–6563,95 with permission of The Royal Society of Chemistry.Abbreviation: TNT, titania nanotube.

Mentions: Magnetic-sensitive drug delivery is a new concept of drug encapsulated in nanomagnetic structures that possess excellent possibilities for magnetic field-triggered drug release. Aw et al designed drug-releasing implants assisted by external magnetic field based on magnetic nanoparticles (MNPs) loaded inside TNTs.95 In this study, TNTs were loaded with three types of amphiphilic micelles at the top acting as drug carriers and MNPs at the bottom of the nanotubes. Meanwhile, dopamine modification of iron oxide MNPs (DOPA-Fe3O4) with soft interfacial cushion were used to improve the biocompatibility of the MNPs, as shown in Figure 8. For the drug-release profiles, it was confirmed that immediate 100% release of all three drug carriers was achieved within 1–1.5 hours upon the application of the magnetic field. Although this strategy also presents some limitations such as uncontrolled release triggered by existing magnetic fields from the environment, it is still particularly valuable for drug-releasing implants in orthopedics and bone surgery where on-demand release is needed under emergency situation. Moreover, Shrestha et al used TNTs filled with MNPs to achieve magnetic- and photocatalytic-guided release of drugs.96 The release concept is based on the fact that the UV-induced hole generation in the valence band of the TiO2 will lead to chain-scission of a monolayer attached to TiO2.


TiO 2 nanotube platforms for smart drug delivery: a review
Schematic representation of the magnetic stimuli-responsive drug release from TNTs which integrates polymer micelles as drug carriers incorporated with poorly soluble drugs and magnetic nanoparticles loaded at the bottom of the nanotubular structures.Notes: The release is achieved by applying an external magnetic field. Reproduced from Aw MS, Addai-Mensah J, Losic D. Magnetic-responsive delivery of drugcarriers using titania nanotube arrays. J Mater Chem. 2012;22:6561–6563,95 with permission of The Royal Society of Chemistry.Abbreviation: TNT, titania nanotube.
© Copyright Policy
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5036548&req=5

f8-ijn-11-4819: Schematic representation of the magnetic stimuli-responsive drug release from TNTs which integrates polymer micelles as drug carriers incorporated with poorly soluble drugs and magnetic nanoparticles loaded at the bottom of the nanotubular structures.Notes: The release is achieved by applying an external magnetic field. Reproduced from Aw MS, Addai-Mensah J, Losic D. Magnetic-responsive delivery of drugcarriers using titania nanotube arrays. J Mater Chem. 2012;22:6561–6563,95 with permission of The Royal Society of Chemistry.Abbreviation: TNT, titania nanotube.
Mentions: Magnetic-sensitive drug delivery is a new concept of drug encapsulated in nanomagnetic structures that possess excellent possibilities for magnetic field-triggered drug release. Aw et al designed drug-releasing implants assisted by external magnetic field based on magnetic nanoparticles (MNPs) loaded inside TNTs.95 In this study, TNTs were loaded with three types of amphiphilic micelles at the top acting as drug carriers and MNPs at the bottom of the nanotubes. Meanwhile, dopamine modification of iron oxide MNPs (DOPA-Fe3O4) with soft interfacial cushion were used to improve the biocompatibility of the MNPs, as shown in Figure 8. For the drug-release profiles, it was confirmed that immediate 100% release of all three drug carriers was achieved within 1–1.5 hours upon the application of the magnetic field. Although this strategy also presents some limitations such as uncontrolled release triggered by existing magnetic fields from the environment, it is still particularly valuable for drug-releasing implants in orthopedics and bone surgery where on-demand release is needed under emergency situation. Moreover, Shrestha et al used TNTs filled with MNPs to achieve magnetic- and photocatalytic-guided release of drugs.96 The release concept is based on the fact that the UV-induced hole generation in the valence band of the TiO2 will lead to chain-scission of a monolayer attached to TiO2.

View Article: PubMed Central - PubMed

ABSTRACT

Titania nanotube (TNT) arrays are recognized as promising materials for localized drug delivery implants because of their excellent properties and facile preparation process. This review highlights the concept of localized drug delivery systems based on TNTs, considering their outstanding biocompatibility in a series of ex vivo and in vivo studies. Considering the safety of TNT implants in the host body, studies of the biocompatibility present significant importance for the clinical application of TNT implants. Toward smart TNT platforms for sustainable drug delivery, several advanced approaches were presented in this review, including controlled release triggered by temperature, light, radiofrequency magnetism, and ultrasonic stimulation. Moreover, TNT implants used in medical therapy have been demonstrated by various examples including dentistry, orthopedic implants, cardiovascular stents, and so on. Finally, a future perspective of TNTs for clinical applications is provided.

No MeSH data available.