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Decreased anticipated pleasure correlates with increased salience network resting state functional connectivity in adolescents with depressive symptomatology

View Article: PubMed Central - PubMed

ABSTRACT

Previous studies have found dysfunctional resting state functional connectivity (RSFC) in depressed patients. Examining RSFC might aid biomarker discovery for depression. However RSFC in young people at risk of depression has yet to be examined.

35 healthy adolescents (13–18 yrs old.) were recruited. 17 scoring high on the Mood and Feelings Questionnaire (MFQ > 27 (High Risk: HR), and 18 scoring low on the MFQ < 15 (Low Risk: LR) matched on age and gender. We selected seed regions in the salience network (SN: amygdala and pregenual anterior cingulate cortex (pgACC)) and the central executive network (CEN: dorsal medial prefrontal cortex (dmPFC)). Mood and anhedonia measures were correlated with brain connectivity.

We found decreased RSFC in the HR group between the amygdala and the pgACC and hippocampus and precuneus. We also found decreased RSFC in the HR group between the pgACC and the putamen and between the dmPFC and the precuneus. The pgACC RSFC with the insula/orbitofrontal cortex correlated inversely with the anticipation of pleasure in all subjects. Increased RSFC was observed between the pgACC and the prefrontal cortex and the amygdala and the temporal pole in the HR group compared to the LR group.

Our findings are the first to show that adolescents with depression symptoms have dysfunctional RSFC between seeds in the SN and CEN with nodes in the Default Mode Network. As increased connectivity between the pgACC and the insula correlated with decreased ability to anticipate pleasure, we suggest this might be mechanism underlying the risk of experiencing anhedonia, a suggested biomarker for depression.

No MeSH data available.


Resting state functional connectivity between the left amygdala seed region  and the precuneus, lower in the HR group than the LR  overlaid on the DMN . % BOLD signal change extracted for connectivity for both of the groups.
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fig1: Resting state functional connectivity between the left amygdala seed region and the precuneus, lower in the HR group than the LR overlaid on the DMN . % BOLD signal change extracted for connectivity for both of the groups.

Mentions: There was decreased RSFC in the HR group compared to the LR group between the left amygdala seed and the pgACC and the precuneus (Fig. 1) and posterior cingulate cortex (PCC) (Table 2).


Decreased anticipated pleasure correlates with increased salience network resting state functional connectivity in adolescents with depressive symptomatology
Resting state functional connectivity between the left amygdala seed region  and the precuneus, lower in the HR group than the LR  overlaid on the DMN . % BOLD signal change extracted for connectivity for both of the groups.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5036507&req=5

fig1: Resting state functional connectivity between the left amygdala seed region and the precuneus, lower in the HR group than the LR overlaid on the DMN . % BOLD signal change extracted for connectivity for both of the groups.
Mentions: There was decreased RSFC in the HR group compared to the LR group between the left amygdala seed and the pgACC and the precuneus (Fig. 1) and posterior cingulate cortex (PCC) (Table 2).

View Article: PubMed Central - PubMed

ABSTRACT

Previous studies have found dysfunctional resting state functional connectivity (RSFC) in depressed patients. Examining RSFC might aid biomarker discovery for depression. However RSFC in young people at risk of depression has yet to be examined.

35 healthy adolescents (13–18 yrs old.) were recruited. 17 scoring high on the Mood and Feelings Questionnaire (MFQ > 27 (High Risk: HR), and 18 scoring low on the MFQ < 15 (Low Risk: LR) matched on age and gender. We selected seed regions in the salience network (SN: amygdala and pregenual anterior cingulate cortex (pgACC)) and the central executive network (CEN: dorsal medial prefrontal cortex (dmPFC)). Mood and anhedonia measures were correlated with brain connectivity.

We found decreased RSFC in the HR group between the amygdala and the pgACC and hippocampus and precuneus. We also found decreased RSFC in the HR group between the pgACC and the putamen and between the dmPFC and the precuneus. The pgACC RSFC with the insula/orbitofrontal cortex correlated inversely with the anticipation of pleasure in all subjects. Increased RSFC was observed between the pgACC and the prefrontal cortex and the amygdala and the temporal pole in the HR group compared to the LR group.

Our findings are the first to show that adolescents with depression symptoms have dysfunctional RSFC between seeds in the SN and CEN with nodes in the Default Mode Network. As increased connectivity between the pgACC and the insula correlated with decreased ability to anticipate pleasure, we suggest this might be mechanism underlying the risk of experiencing anhedonia, a suggested biomarker for depression.

No MeSH data available.