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Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications

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ABSTRACT

This review focuses on the recent development and various strategies in the preparation, microstructure, and magnetic properties of bare and surface functionalized iron oxide nanoparticles (IONPs); their corresponding biological application was also discussed. In order to implement the practical in vivo or in vitro applications, the IONPs must have combined properties of high magnetic saturation, stability, biocompatibility, and interactive functions at the surface. Moreover, the surface of IONPs could be modified by organic materials or inorganic materials, such as polymers, biomolecules, silica, metals, etc. The new functionalized strategies, problems and major challenges, along with the current directions for the synthesis, surface functionalization and bioapplication of IONPs, are considered. Finally, some future trends and the prospects in these research areas are also discussed.

No MeSH data available.


Schematic diagram showing preparation of Fe3O4–GO composites and using for cellular MRI. (Reprinted with permission from W H Chen et al 2011 ACS Appl. Mater. Interfaces3 4085. Copyright 2011 American Chemical Society.)
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Figure 17: Schematic diagram showing preparation of Fe3O4–GO composites and using for cellular MRI. (Reprinted with permission from W H Chen et al 2011 ACS Appl. Mater. Interfaces3 4085. Copyright 2011 American Chemical Society.)

Mentions: Moreover, Fe3O4/graphene hybrid materials have been used in biological fields, such as targeted drug delivery and MRI [241–243]. For example, Chen et al have reported that the fabricated composites of aminodextran-coated Fe3O4 NPs and GO were efficient for cellular MRI. As shown in figure 17, the in vivo study showed that the internalization of Fe3O4–GO composites has no effect on the cellular viability and proliferation. Compared to the bare Fe3O4 NPs, the Fe3O4–GO composites exhibit a significantly improved T2 weighted MRI contrast, which is explained by the fact that the Fe3O4 NPs formed aggregates on the GO sheets, resulting in a considerable enhanced T2 relaxivity [244].


Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications
Schematic diagram showing preparation of Fe3O4–GO composites and using for cellular MRI. (Reprinted with permission from W H Chen et al 2011 ACS Appl. Mater. Interfaces3 4085. Copyright 2011 American Chemical Society.)
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5036481&req=5

Figure 17: Schematic diagram showing preparation of Fe3O4–GO composites and using for cellular MRI. (Reprinted with permission from W H Chen et al 2011 ACS Appl. Mater. Interfaces3 4085. Copyright 2011 American Chemical Society.)
Mentions: Moreover, Fe3O4/graphene hybrid materials have been used in biological fields, such as targeted drug delivery and MRI [241–243]. For example, Chen et al have reported that the fabricated composites of aminodextran-coated Fe3O4 NPs and GO were efficient for cellular MRI. As shown in figure 17, the in vivo study showed that the internalization of Fe3O4–GO composites has no effect on the cellular viability and proliferation. Compared to the bare Fe3O4 NPs, the Fe3O4–GO composites exhibit a significantly improved T2 weighted MRI contrast, which is explained by the fact that the Fe3O4 NPs formed aggregates on the GO sheets, resulting in a considerable enhanced T2 relaxivity [244].

View Article: PubMed Central - PubMed

ABSTRACT

This review focuses on the recent development and various strategies in the preparation, microstructure, and magnetic properties of bare and surface functionalized iron oxide nanoparticles (IONPs); their corresponding biological application was also discussed. In order to implement the practical in vivo or in vitro applications, the IONPs must have combined properties of high magnetic saturation, stability, biocompatibility, and interactive functions at the surface. Moreover, the surface of IONPs could be modified by organic materials or inorganic materials, such as polymers, biomolecules, silica, metals, etc. The new functionalized strategies, problems and major challenges, along with the current directions for the synthesis, surface functionalization and bioapplication of IONPs, are considered. Finally, some future trends and the prospects in these research areas are also discussed.

No MeSH data available.