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Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications

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ABSTRACT

This review focuses on the recent development and various strategies in the preparation, microstructure, and magnetic properties of bare and surface functionalized iron oxide nanoparticles (IONPs); their corresponding biological application was also discussed. In order to implement the practical in vivo or in vitro applications, the IONPs must have combined properties of high magnetic saturation, stability, biocompatibility, and interactive functions at the surface. Moreover, the surface of IONPs could be modified by organic materials or inorganic materials, such as polymers, biomolecules, silica, metals, etc. The new functionalized strategies, problems and major challenges, along with the current directions for the synthesis, surface functionalization and bioapplication of IONPs, are considered. Finally, some future trends and the prospects in these research areas are also discussed.

No MeSH data available.


Schematic illustration of the fabrication of IONP@C composites.
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Figure 16: Schematic illustration of the fabrication of IONP@C composites.

Mentions: Various approaches have been developed for synthesizing IONP@C core–shell nanostructures. As shown in figure 16, the common approach is a three-step process: firstly, magnetic IONPs are prepared as seeds by various methods, and then the polymer is coated through the polymerization process, finally forming IONP@C composite materials by annealing treatment. For example, Lei et al demonstrated that through a controlled coating of a thin layer of polydopamine on the surface of α-Fe2O3 in the dopamine aqueous solution, followed by subsequent carbonization, N-doped carbon-encapsulated magnetite has been synthesized and displayed excellent electrochemical performance as an anode material for lithium-ion batteries [232]. Li et al reported for the first time for the selected-control, large-scale synthesis of monodispersed Fe3O4@C core–shell spheres, chains, and rings with tunable magnetic properties based on structural evolution from eccentric Fe2O3@poly(acrylic acid) core–shell NPs [233].


Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications
Schematic illustration of the fabrication of IONP@C composites.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5036481&req=5

Figure 16: Schematic illustration of the fabrication of IONP@C composites.
Mentions: Various approaches have been developed for synthesizing IONP@C core–shell nanostructures. As shown in figure 16, the common approach is a three-step process: firstly, magnetic IONPs are prepared as seeds by various methods, and then the polymer is coated through the polymerization process, finally forming IONP@C composite materials by annealing treatment. For example, Lei et al demonstrated that through a controlled coating of a thin layer of polydopamine on the surface of α-Fe2O3 in the dopamine aqueous solution, followed by subsequent carbonization, N-doped carbon-encapsulated magnetite has been synthesized and displayed excellent electrochemical performance as an anode material for lithium-ion batteries [232]. Li et al reported for the first time for the selected-control, large-scale synthesis of monodispersed Fe3O4@C core–shell spheres, chains, and rings with tunable magnetic properties based on structural evolution from eccentric Fe2O3@poly(acrylic acid) core–shell NPs [233].

View Article: PubMed Central - PubMed

ABSTRACT

This review focuses on the recent development and various strategies in the preparation, microstructure, and magnetic properties of bare and surface functionalized iron oxide nanoparticles (IONPs); their corresponding biological application was also discussed. In order to implement the practical in vivo or in vitro applications, the IONPs must have combined properties of high magnetic saturation, stability, biocompatibility, and interactive functions at the surface. Moreover, the surface of IONPs could be modified by organic materials or inorganic materials, such as polymers, biomolecules, silica, metals, etc. The new functionalized strategies, problems and major challenges, along with the current directions for the synthesis, surface functionalization and bioapplication of IONPs, are considered. Finally, some future trends and the prospects in these research areas are also discussed.

No MeSH data available.