Limits...
Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications

View Article: PubMed Central - PubMed

ABSTRACT

This review focuses on the recent development and various strategies in the preparation, microstructure, and magnetic properties of bare and surface functionalized iron oxide nanoparticles (IONPs); their corresponding biological application was also discussed. In order to implement the practical in vivo or in vitro applications, the IONPs must have combined properties of high magnetic saturation, stability, biocompatibility, and interactive functions at the surface. Moreover, the surface of IONPs could be modified by organic materials or inorganic materials, such as polymers, biomolecules, silica, metals, etc. The new functionalized strategies, problems and major challenges, along with the current directions for the synthesis, surface functionalization and bioapplication of IONPs, are considered. Finally, some future trends and the prospects in these research areas are also discussed.

No MeSH data available.


(a) La Mer-like diagram: hydrolyzed TEOS (monomers) concentration against time on homogeneous nucleation and heterogeneous nucleation, (b) the existence of Fe3O4@SiO2 core/shell NPs and SiO2 NPs in the reaction production when C > Chomo at some moment, (c) only the existence of Fe3O4@SiO2 core/shell NPs in the reaction production when C < Chomo at any moment. (Reprinted with permission from H L Ding et al 2012 Chem. Mater.24 4572. Copyright 2012 American Chemical Society.)
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC5036481&req=5

Figure 15: (a) La Mer-like diagram: hydrolyzed TEOS (monomers) concentration against time on homogeneous nucleation and heterogeneous nucleation, (b) the existence of Fe3O4@SiO2 core/shell NPs and SiO2 NPs in the reaction production when C > Chomo at some moment, (c) only the existence of Fe3O4@SiO2 core/shell NPs in the reaction production when C < Chomo at any moment. (Reprinted with permission from H L Ding et al 2012 Chem. Mater.24 4572. Copyright 2012 American Chemical Society.)

Mentions: The second method was based on microemulsion synthesis, in which micelles or inverse micelles were used to confine and control the coating of silica on core NPs [227]. It is noteworthy that this method requires much effort to separate the core–shell NPs from the large amount of surfactants associated with the microemulsion system. Recently, Ding et al reported the coating regulations of Fe3O4 NPs by the reverse microemulsion method to obtain Fe3O4@SiO2 core–shell NPs. As shown in figure 15, the regulation produces core–shell NPs with a single core and with different shell thickness and especially it can be applied to different sizes of Fe3O4 NPs and avoid the formation of core-free silica particles. The small aqueous domain was suitable to coat ultrathin silica shell, while the large aqueous domain was indispensable for coating thicker shells. To avoid the formation of core-free silica particles, the thicker silica shells were achieved by increasing the content of either TEOS through the equivalently fractionated drops or ammonia with a decreased one-off TEOS [228]. The advantage of this method is that uniform silica shells with controlled thickness on the nanometer scale can be realized.


Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications
(a) La Mer-like diagram: hydrolyzed TEOS (monomers) concentration against time on homogeneous nucleation and heterogeneous nucleation, (b) the existence of Fe3O4@SiO2 core/shell NPs and SiO2 NPs in the reaction production when C > Chomo at some moment, (c) only the existence of Fe3O4@SiO2 core/shell NPs in the reaction production when C < Chomo at any moment. (Reprinted with permission from H L Ding et al 2012 Chem. Mater.24 4572. Copyright 2012 American Chemical Society.)
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5036481&req=5

Figure 15: (a) La Mer-like diagram: hydrolyzed TEOS (monomers) concentration against time on homogeneous nucleation and heterogeneous nucleation, (b) the existence of Fe3O4@SiO2 core/shell NPs and SiO2 NPs in the reaction production when C > Chomo at some moment, (c) only the existence of Fe3O4@SiO2 core/shell NPs in the reaction production when C < Chomo at any moment. (Reprinted with permission from H L Ding et al 2012 Chem. Mater.24 4572. Copyright 2012 American Chemical Society.)
Mentions: The second method was based on microemulsion synthesis, in which micelles or inverse micelles were used to confine and control the coating of silica on core NPs [227]. It is noteworthy that this method requires much effort to separate the core–shell NPs from the large amount of surfactants associated with the microemulsion system. Recently, Ding et al reported the coating regulations of Fe3O4 NPs by the reverse microemulsion method to obtain Fe3O4@SiO2 core–shell NPs. As shown in figure 15, the regulation produces core–shell NPs with a single core and with different shell thickness and especially it can be applied to different sizes of Fe3O4 NPs and avoid the formation of core-free silica particles. The small aqueous domain was suitable to coat ultrathin silica shell, while the large aqueous domain was indispensable for coating thicker shells. To avoid the formation of core-free silica particles, the thicker silica shells were achieved by increasing the content of either TEOS through the equivalently fractionated drops or ammonia with a decreased one-off TEOS [228]. The advantage of this method is that uniform silica shells with controlled thickness on the nanometer scale can be realized.

View Article: PubMed Central - PubMed

ABSTRACT

This review focuses on the recent development and various strategies in the preparation, microstructure, and magnetic properties of bare and surface functionalized iron oxide nanoparticles (IONPs); their corresponding biological application was also discussed. In order to implement the practical in vivo or in vitro applications, the IONPs must have combined properties of high magnetic saturation, stability, biocompatibility, and interactive functions at the surface. Moreover, the surface of IONPs could be modified by organic materials or inorganic materials, such as polymers, biomolecules, silica, metals, etc. The new functionalized strategies, problems and major challenges, along with the current directions for the synthesis, surface functionalization and bioapplication of IONPs, are considered. Finally, some future trends and the prospects in these research areas are also discussed.

No MeSH data available.