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Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications

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ABSTRACT

This review focuses on the recent development and various strategies in the preparation, microstructure, and magnetic properties of bare and surface functionalized iron oxide nanoparticles (IONPs); their corresponding biological application was also discussed. In order to implement the practical in vivo or in vitro applications, the IONPs must have combined properties of high magnetic saturation, stability, biocompatibility, and interactive functions at the surface. Moreover, the surface of IONPs could be modified by organic materials or inorganic materials, such as polymers, biomolecules, silica, metals, etc. The new functionalized strategies, problems and major challenges, along with the current directions for the synthesis, surface functionalization and bioapplication of IONPs, are considered. Finally, some future trends and the prospects in these research areas are also discussed.

No MeSH data available.


Typical morphologies of magnetic composite nanomaterials. Blue spheres represent magnetic IONPs, and the non-magnetic entities and matrix materials are displayed in other colors. The nonmagnetic entity may provide the composite material with further functionalities and properties, providing multifunctional hybrid systems.
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Figure 11: Typical morphologies of magnetic composite nanomaterials. Blue spheres represent magnetic IONPs, and the non-magnetic entities and matrix materials are displayed in other colors. The nonmagnetic entity may provide the composite material with further functionalities and properties, providing multifunctional hybrid systems.

Mentions: In view of the many strategies and their subsequent application, efforts have been devoted to fabricating four types of IONP-based materials, including the core–shell structure, matrix dispersed structure, Janus-type heterostructures and shell–core–shell structure (figure 11).


Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications
Typical morphologies of magnetic composite nanomaterials. Blue spheres represent magnetic IONPs, and the non-magnetic entities and matrix materials are displayed in other colors. The nonmagnetic entity may provide the composite material with further functionalities and properties, providing multifunctional hybrid systems.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5036481&req=5

Figure 11: Typical morphologies of magnetic composite nanomaterials. Blue spheres represent magnetic IONPs, and the non-magnetic entities and matrix materials are displayed in other colors. The nonmagnetic entity may provide the composite material with further functionalities and properties, providing multifunctional hybrid systems.
Mentions: In view of the many strategies and their subsequent application, efforts have been devoted to fabricating four types of IONP-based materials, including the core–shell structure, matrix dispersed structure, Janus-type heterostructures and shell–core–shell structure (figure 11).

View Article: PubMed Central - PubMed

ABSTRACT

This review focuses on the recent development and various strategies in the preparation, microstructure, and magnetic properties of bare and surface functionalized iron oxide nanoparticles (IONPs); their corresponding biological application was also discussed. In order to implement the practical in vivo or in vitro applications, the IONPs must have combined properties of high magnetic saturation, stability, biocompatibility, and interactive functions at the surface. Moreover, the surface of IONPs could be modified by organic materials or inorganic materials, such as polymers, biomolecules, silica, metals, etc. The new functionalized strategies, problems and major challenges, along with the current directions for the synthesis, surface functionalization and bioapplication of IONPs, are considered. Finally, some future trends and the prospects in these research areas are also discussed.

No MeSH data available.