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Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications

View Article: PubMed Central - PubMed

ABSTRACT

This review focuses on the recent development and various strategies in the preparation, microstructure, and magnetic properties of bare and surface functionalized iron oxide nanoparticles (IONPs); their corresponding biological application was also discussed. In order to implement the practical in vivo or in vitro applications, the IONPs must have combined properties of high magnetic saturation, stability, biocompatibility, and interactive functions at the surface. Moreover, the surface of IONPs could be modified by organic materials or inorganic materials, such as polymers, biomolecules, silica, metals, etc. The new functionalized strategies, problems and major challenges, along with the current directions for the synthesis, surface functionalization and bioapplication of IONPs, are considered. Finally, some future trends and the prospects in these research areas are also discussed.

No MeSH data available.


Related in: MedlinePlus

Detail of the reaction area where the laser interacts with the gas reactants and the influence of the collection system to obtain larger aggregates (solid filter) or well-dispersed ultrasmall IONPs (solution, the size is below 5 nm) under similar experimental conditions.
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Figure 10: Detail of the reaction area where the laser interacts with the gas reactants and the influence of the collection system to obtain larger aggregates (solid filter) or well-dispersed ultrasmall IONPs (solution, the size is below 5 nm) under similar experimental conditions.

Mentions: Spray and laser pyrolysis are the main aerosol technologies for fabricating magnetic IONPs. In spray pyrolysis, fine IONPs are produced by the evaporation of ferric salts, drying, and pyrolysis reaction of liquid drops (a reducing agent in organic solvent) inside a high temperature atmosphere, especially the flame-spray. Particle size and size distribution depend on the size and size distribution of liquid drops, and the evaporation process of a solvent and the property of the starting material. Recently, Abid et al reported IONPs with variable oxidation states by flame-spray pyrolysis, revealing that the different flame configurations are an important factor of the morphology and size control of the final IONPs [114]. For reducing the reaction volume, laser became the energy resource and heated a gaseous mixture of iron precursor and a flowing mixture of gas producing small, narrow size, and non-aggregated NPs in the pyrolysis process (as shown in figure 10). Importantly, laser pyrolysis can produce well-dispersed fine IONPs. For example, Costo et al have synthesized very high crystallinity, and ultrasmall NPs (<5 nm) with a rather spheroid morphology and exceptionally narrow particle size distributions through an optimized acid treatment. The dissolution of the disordered layer from the particle surface and further recrystallization of an iron polymer activated the surface and prepared the particles for further functionalization with bioactive ligands [115]. However, the final IONPs made by this process had a very broad size distribution due to the difficulty of obtaining a uniform size of initial droplets or gaseous mixture.


Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications
Detail of the reaction area where the laser interacts with the gas reactants and the influence of the collection system to obtain larger aggregates (solid filter) or well-dispersed ultrasmall IONPs (solution, the size is below 5 nm) under similar experimental conditions.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5036481&req=5

Figure 10: Detail of the reaction area where the laser interacts with the gas reactants and the influence of the collection system to obtain larger aggregates (solid filter) or well-dispersed ultrasmall IONPs (solution, the size is below 5 nm) under similar experimental conditions.
Mentions: Spray and laser pyrolysis are the main aerosol technologies for fabricating magnetic IONPs. In spray pyrolysis, fine IONPs are produced by the evaporation of ferric salts, drying, and pyrolysis reaction of liquid drops (a reducing agent in organic solvent) inside a high temperature atmosphere, especially the flame-spray. Particle size and size distribution depend on the size and size distribution of liquid drops, and the evaporation process of a solvent and the property of the starting material. Recently, Abid et al reported IONPs with variable oxidation states by flame-spray pyrolysis, revealing that the different flame configurations are an important factor of the morphology and size control of the final IONPs [114]. For reducing the reaction volume, laser became the energy resource and heated a gaseous mixture of iron precursor and a flowing mixture of gas producing small, narrow size, and non-aggregated NPs in the pyrolysis process (as shown in figure 10). Importantly, laser pyrolysis can produce well-dispersed fine IONPs. For example, Costo et al have synthesized very high crystallinity, and ultrasmall NPs (<5 nm) with a rather spheroid morphology and exceptionally narrow particle size distributions through an optimized acid treatment. The dissolution of the disordered layer from the particle surface and further recrystallization of an iron polymer activated the surface and prepared the particles for further functionalization with bioactive ligands [115]. However, the final IONPs made by this process had a very broad size distribution due to the difficulty of obtaining a uniform size of initial droplets or gaseous mixture.

View Article: PubMed Central - PubMed

ABSTRACT

This review focuses on the recent development and various strategies in the preparation, microstructure, and magnetic properties of bare and surface functionalized iron oxide nanoparticles (IONPs); their corresponding biological application was also discussed. In order to implement the practical in vivo or in vitro applications, the IONPs must have combined properties of high magnetic saturation, stability, biocompatibility, and interactive functions at the surface. Moreover, the surface of IONPs could be modified by organic materials or inorganic materials, such as polymers, biomolecules, silica, metals, etc. The new functionalized strategies, problems and major challenges, along with the current directions for the synthesis, surface functionalization and bioapplication of IONPs, are considered. Finally, some future trends and the prospects in these research areas are also discussed.

No MeSH data available.


Related in: MedlinePlus