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Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications

View Article: PubMed Central - PubMed

ABSTRACT

This review focuses on the recent development and various strategies in the preparation, microstructure, and magnetic properties of bare and surface functionalized iron oxide nanoparticles (IONPs); their corresponding biological application was also discussed. In order to implement the practical in vivo or in vitro applications, the IONPs must have combined properties of high magnetic saturation, stability, biocompatibility, and interactive functions at the surface. Moreover, the surface of IONPs could be modified by organic materials or inorganic materials, such as polymers, biomolecules, silica, metals, etc. The new functionalized strategies, problems and major challenges, along with the current directions for the synthesis, surface functionalization and bioapplication of IONPs, are considered. Finally, some future trends and the prospects in these research areas are also discussed.

No MeSH data available.


Schematic diagram of the procedure for the encapsulation of Fe3O4 NPs and monomer droplet to latex particle conversion by the sonochemically driven miniemulsion polymerization pathway. (Reprinted with permission from B M Teo et al 2009 Langmuir25 2593. Copyright 2009 American Chemical Society.)
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Figure 8: Schematic diagram of the procedure for the encapsulation of Fe3O4 NPs and monomer droplet to latex particle conversion by the sonochemically driven miniemulsion polymerization pathway. (Reprinted with permission from B M Teo et al 2009 Langmuir25 2593. Copyright 2009 American Chemical Society.)

Mentions: In addition, the ultrasound-initiated procedure, as a technology, represents an effective and innocuous means of producing a range of nanocomposites, consisting of multiple combinations of different polymers and encapsulated materials. Teo et al have developed a simple and efficient method for preparing 100 nm latex beads loaded with a high content of Fe3O4 NPs; the formation procedure of Fe3O4 NPs under the ultrasound-initiated effect is well illustrated in figure 8. The NPs exhibited excellent colloidal stability (remained suspended stably in an aqueous solution for more than 12 months with no noticeable degradation) and strong magnetic properties (superparamagnetic with a saturated magnetization of 24 emu g−1), and were of the desired size to be technologically relevant [88]. The sonochemical method has some advantages, including uniformity of mixing and reduction of crystal growth, which can also lead to an acceleration effect in chemical dynamics and rates of the reactions. However, the sonolysis method is not beneficial to realize the fabrication of IONPs with controllable shapes and dispersity.


Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications
Schematic diagram of the procedure for the encapsulation of Fe3O4 NPs and monomer droplet to latex particle conversion by the sonochemically driven miniemulsion polymerization pathway. (Reprinted with permission from B M Teo et al 2009 Langmuir25 2593. Copyright 2009 American Chemical Society.)
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5036481&req=5

Figure 8: Schematic diagram of the procedure for the encapsulation of Fe3O4 NPs and monomer droplet to latex particle conversion by the sonochemically driven miniemulsion polymerization pathway. (Reprinted with permission from B M Teo et al 2009 Langmuir25 2593. Copyright 2009 American Chemical Society.)
Mentions: In addition, the ultrasound-initiated procedure, as a technology, represents an effective and innocuous means of producing a range of nanocomposites, consisting of multiple combinations of different polymers and encapsulated materials. Teo et al have developed a simple and efficient method for preparing 100 nm latex beads loaded with a high content of Fe3O4 NPs; the formation procedure of Fe3O4 NPs under the ultrasound-initiated effect is well illustrated in figure 8. The NPs exhibited excellent colloidal stability (remained suspended stably in an aqueous solution for more than 12 months with no noticeable degradation) and strong magnetic properties (superparamagnetic with a saturated magnetization of 24 emu g−1), and were of the desired size to be technologically relevant [88]. The sonochemical method has some advantages, including uniformity of mixing and reduction of crystal growth, which can also lead to an acceleration effect in chemical dynamics and rates of the reactions. However, the sonolysis method is not beneficial to realize the fabrication of IONPs with controllable shapes and dispersity.

View Article: PubMed Central - PubMed

ABSTRACT

This review focuses on the recent development and various strategies in the preparation, microstructure, and magnetic properties of bare and surface functionalized iron oxide nanoparticles (IONPs); their corresponding biological application was also discussed. In order to implement the practical in vivo or in vitro applications, the IONPs must have combined properties of high magnetic saturation, stability, biocompatibility, and interactive functions at the surface. Moreover, the surface of IONPs could be modified by organic materials or inorganic materials, such as polymers, biomolecules, silica, metals, etc. The new functionalized strategies, problems and major challenges, along with the current directions for the synthesis, surface functionalization and bioapplication of IONPs, are considered. Finally, some future trends and the prospects in these research areas are also discussed.

No MeSH data available.