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Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications

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ABSTRACT

This review focuses on the recent development and various strategies in the preparation, microstructure, and magnetic properties of bare and surface functionalized iron oxide nanoparticles (IONPs); their corresponding biological application was also discussed. In order to implement the practical in vivo or in vitro applications, the IONPs must have combined properties of high magnetic saturation, stability, biocompatibility, and interactive functions at the surface. Moreover, the surface of IONPs could be modified by organic materials or inorganic materials, such as polymers, biomolecules, silica, metals, etc. The new functionalized strategies, problems and major challenges, along with the current directions for the synthesis, surface functionalization and bioapplication of IONPs, are considered. Finally, some future trends and the prospects in these research areas are also discussed.

No MeSH data available.


Schematic illustration of the shape evolution for hematite nanostructures at different reaction times and different ferric concentrations. (Reprinted with permission from W Wu et al 2010 J. Phys. Chem. C 114 16092. Copyright 2010 American Chemical Society.)
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Figure 7: Schematic illustration of the shape evolution for hematite nanostructures at different reaction times and different ferric concentrations. (Reprinted with permission from W Wu et al 2010 J. Phys. Chem. C 114 16092. Copyright 2010 American Chemical Society.)

Mentions: In addition, the hydrothermal and solvothermal route is beneficial to obtaining shape-controlled IONPs. We present a facile approach for the production of magnetic iron oxide short nanotubes (SNTs) and other shapes (NPs, nanorings) employing an anion-assisted hydrothermal route by using phosphate and sulfate ions. As shown in figure 7, the size, morphology, shape, and surface architecture control of the iron oxide SNTs are achieved by simple adjustments of ferric ion concentration without any surfactant assistance. Investigation of the formation mechanism reveals that the ferric ion concentrations, the amount of anion additive, and the reaction time contribute significantly to SNT growth. The shape of the SNTs is mainly regulated by the adsorption of phosphate ions on faces parallel to the long dimension of elongated α-Fe2O3 NPs (axis) during nanocrystal growth, and the hollow structure is given by the preferential dissolution along the c-axis due to the strong coordination of the sulfate ions. Moreover, the as-synthesized hematite (α-Fe2O3) SNTs can be converted to magnetite (Fe3O4) and maghemite (γ-Fe2O3) ferromagnetic SNTs by a reducing atmosphere annealing process while preserving the same morphology [10].


Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications
Schematic illustration of the shape evolution for hematite nanostructures at different reaction times and different ferric concentrations. (Reprinted with permission from W Wu et al 2010 J. Phys. Chem. C 114 16092. Copyright 2010 American Chemical Society.)
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5036481&req=5

Figure 7: Schematic illustration of the shape evolution for hematite nanostructures at different reaction times and different ferric concentrations. (Reprinted with permission from W Wu et al 2010 J. Phys. Chem. C 114 16092. Copyright 2010 American Chemical Society.)
Mentions: In addition, the hydrothermal and solvothermal route is beneficial to obtaining shape-controlled IONPs. We present a facile approach for the production of magnetic iron oxide short nanotubes (SNTs) and other shapes (NPs, nanorings) employing an anion-assisted hydrothermal route by using phosphate and sulfate ions. As shown in figure 7, the size, morphology, shape, and surface architecture control of the iron oxide SNTs are achieved by simple adjustments of ferric ion concentration without any surfactant assistance. Investigation of the formation mechanism reveals that the ferric ion concentrations, the amount of anion additive, and the reaction time contribute significantly to SNT growth. The shape of the SNTs is mainly regulated by the adsorption of phosphate ions on faces parallel to the long dimension of elongated α-Fe2O3 NPs (axis) during nanocrystal growth, and the hollow structure is given by the preferential dissolution along the c-axis due to the strong coordination of the sulfate ions. Moreover, the as-synthesized hematite (α-Fe2O3) SNTs can be converted to magnetite (Fe3O4) and maghemite (γ-Fe2O3) ferromagnetic SNTs by a reducing atmosphere annealing process while preserving the same morphology [10].

View Article: PubMed Central - PubMed

ABSTRACT

This review focuses on the recent development and various strategies in the preparation, microstructure, and magnetic properties of bare and surface functionalized iron oxide nanoparticles (IONPs); their corresponding biological application was also discussed. In order to implement the practical in vivo or in vitro applications, the IONPs must have combined properties of high magnetic saturation, stability, biocompatibility, and interactive functions at the surface. Moreover, the surface of IONPs could be modified by organic materials or inorganic materials, such as polymers, biomolecules, silica, metals, etc. The new functionalized strategies, problems and major challenges, along with the current directions for the synthesis, surface functionalization and bioapplication of IONPs, are considered. Finally, some future trends and the prospects in these research areas are also discussed.

No MeSH data available.