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Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications

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ABSTRACT

This review focuses on the recent development and various strategies in the preparation, microstructure, and magnetic properties of bare and surface functionalized iron oxide nanoparticles (IONPs); their corresponding biological application was also discussed. In order to implement the practical in vivo or in vitro applications, the IONPs must have combined properties of high magnetic saturation, stability, biocompatibility, and interactive functions at the surface. Moreover, the surface of IONPs could be modified by organic materials or inorganic materials, such as polymers, biomolecules, silica, metals, etc. The new functionalized strategies, problems and major challenges, along with the current directions for the synthesis, surface functionalization and bioapplication of IONPs, are considered. Finally, some future trends and the prospects in these research areas are also discussed.

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Monodisperse IONPs with spherical and cubic morphologies are prepared by the thermal decomposition of FeOOH, and exhibit very different blocking temperatures. (Reprinted with permission from R Chalasani and S Vasudevan 2011 J. Phys. Chem. C 115 18088. Copyright 2010 American Chemical Society.)
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Figure 6: Monodisperse IONPs with spherical and cubic morphologies are prepared by the thermal decomposition of FeOOH, and exhibit very different blocking temperatures. (Reprinted with permission from R Chalasani and S Vasudevan 2011 J. Phys. Chem. C 115 18088. Copyright 2010 American Chemical Society.)

Mentions: Moreover, the thermal decomposition method is often used to prepare iron oxide with different shapes, such as nanocubes and nanospheres. For example, Amara et al synthesized Fe3O4 nanocubes and nanospheres by solventless thermal decomposition of various mixtures of ferrocene and polyvinylpyrrolidone (PVP). The described method offered a new simple, single-step process for the preparation of magnetite nanocubes/spheres [42]. As shown in figure 6, Chalasani and Vasudevan have reported monodisperse iron oxide nanocrystals with spherical and cubic morphologies that were prepared by the thermal decomposition of FeOOH. The higher TB values in particles of cubic morphology are shown to be a consequence of exchange bias fields. The results reveal that the exchange bias fields originate from the presence of trace amounts of wustite, FeO [43]. In fact, the magnetic properties of IONPs are also associated with the shape and size of the NPs [16, 44, 45].


Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications
Monodisperse IONPs with spherical and cubic morphologies are prepared by the thermal decomposition of FeOOH, and exhibit very different blocking temperatures. (Reprinted with permission from R Chalasani and S Vasudevan 2011 J. Phys. Chem. C 115 18088. Copyright 2010 American Chemical Society.)
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5036481&req=5

Figure 6: Monodisperse IONPs with spherical and cubic morphologies are prepared by the thermal decomposition of FeOOH, and exhibit very different blocking temperatures. (Reprinted with permission from R Chalasani and S Vasudevan 2011 J. Phys. Chem. C 115 18088. Copyright 2010 American Chemical Society.)
Mentions: Moreover, the thermal decomposition method is often used to prepare iron oxide with different shapes, such as nanocubes and nanospheres. For example, Amara et al synthesized Fe3O4 nanocubes and nanospheres by solventless thermal decomposition of various mixtures of ferrocene and polyvinylpyrrolidone (PVP). The described method offered a new simple, single-step process for the preparation of magnetite nanocubes/spheres [42]. As shown in figure 6, Chalasani and Vasudevan have reported monodisperse iron oxide nanocrystals with spherical and cubic morphologies that were prepared by the thermal decomposition of FeOOH. The higher TB values in particles of cubic morphology are shown to be a consequence of exchange bias fields. The results reveal that the exchange bias fields originate from the presence of trace amounts of wustite, FeO [43]. In fact, the magnetic properties of IONPs are also associated with the shape and size of the NPs [16, 44, 45].

View Article: PubMed Central - PubMed

ABSTRACT

This review focuses on the recent development and various strategies in the preparation, microstructure, and magnetic properties of bare and surface functionalized iron oxide nanoparticles (IONPs); their corresponding biological application was also discussed. In order to implement the practical in vivo or in vitro applications, the IONPs must have combined properties of high magnetic saturation, stability, biocompatibility, and interactive functions at the surface. Moreover, the surface of IONPs could be modified by organic materials or inorganic materials, such as polymers, biomolecules, silica, metals, etc. The new functionalized strategies, problems and major challenges, along with the current directions for the synthesis, surface functionalization and bioapplication of IONPs, are considered. Finally, some future trends and the prospects in these research areas are also discussed.

No MeSH data available.


Related in: MedlinePlus