Limits...
Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications

View Article: PubMed Central - PubMed

ABSTRACT

This review focuses on the recent development and various strategies in the preparation, microstructure, and magnetic properties of bare and surface functionalized iron oxide nanoparticles (IONPs); their corresponding biological application was also discussed. In order to implement the practical in vivo or in vitro applications, the IONPs must have combined properties of high magnetic saturation, stability, biocompatibility, and interactive functions at the surface. Moreover, the surface of IONPs could be modified by organic materials or inorganic materials, such as polymers, biomolecules, silica, metals, etc. The new functionalized strategies, problems and major challenges, along with the current directions for the synthesis, surface functionalization and bioapplication of IONPs, are considered. Finally, some future trends and the prospects in these research areas are also discussed.

No MeSH data available.


Schematic showing the in situ co-precipitation synthesis process of IONPs in polymer. (Reprinted with permission from S K Suh et al 2012 J. Am. Chem. Soc.134 7337. Copyright 2012 American Chemical Society.)
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC5036481&req=5

Figure 4: Schematic showing the in situ co-precipitation synthesis process of IONPs in polymer. (Reprinted with permission from S K Suh et al 2012 J. Am. Chem. Soc.134 7337. Copyright 2012 American Chemical Society.)

Mentions: Currently, the problems of aggregation and biocompatibility of IONPs perhaps hinder the applications in biomedical fields. Therefore, many surfactants and biomolecules have been introduced directly in the co-precipitation process. For instance, Salavati-Niasari et al have reported Fe3O4 NPs with a size range of 25 nm that were prepared by a facile chemical co-precipitation method; the surfactant octanoic acid was present in the reaction system to improve the dispersity [25]. Liu et al have prepared magnetic chitosan coated Fe3O4 NPs by the co-precipitation method under 0.45 T static magnetic fields, which assisted the glutaraldehyde cross-linking reaction; the water was replaced by 2% chitosan in an acetic acid solution during the reaction process. The resulting NPs were used to immobilize lipase [26]. Recently, Suh et al have reported an in situ synthesis of nonspherical magnetic IONPs in a carboxyl functionalized polymer matrix, in which the iron ions diffused into the polymer particles and they were allowed to chelate with the deprotonated carboxyl groups, nucleated and finally grew to the IONPs in the polymer particles (figure 4) [27]. This method can be used to add multiple functionalities, such as the addition of biomolecules after subsequent reactions.


Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications
Schematic showing the in situ co-precipitation synthesis process of IONPs in polymer. (Reprinted with permission from S K Suh et al 2012 J. Am. Chem. Soc.134 7337. Copyright 2012 American Chemical Society.)
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5036481&req=5

Figure 4: Schematic showing the in situ co-precipitation synthesis process of IONPs in polymer. (Reprinted with permission from S K Suh et al 2012 J. Am. Chem. Soc.134 7337. Copyright 2012 American Chemical Society.)
Mentions: Currently, the problems of aggregation and biocompatibility of IONPs perhaps hinder the applications in biomedical fields. Therefore, many surfactants and biomolecules have been introduced directly in the co-precipitation process. For instance, Salavati-Niasari et al have reported Fe3O4 NPs with a size range of 25 nm that were prepared by a facile chemical co-precipitation method; the surfactant octanoic acid was present in the reaction system to improve the dispersity [25]. Liu et al have prepared magnetic chitosan coated Fe3O4 NPs by the co-precipitation method under 0.45 T static magnetic fields, which assisted the glutaraldehyde cross-linking reaction; the water was replaced by 2% chitosan in an acetic acid solution during the reaction process. The resulting NPs were used to immobilize lipase [26]. Recently, Suh et al have reported an in situ synthesis of nonspherical magnetic IONPs in a carboxyl functionalized polymer matrix, in which the iron ions diffused into the polymer particles and they were allowed to chelate with the deprotonated carboxyl groups, nucleated and finally grew to the IONPs in the polymer particles (figure 4) [27]. This method can be used to add multiple functionalities, such as the addition of biomolecules after subsequent reactions.

View Article: PubMed Central - PubMed

ABSTRACT

This review focuses on the recent development and various strategies in the preparation, microstructure, and magnetic properties of bare and surface functionalized iron oxide nanoparticles (IONPs); their corresponding biological application was also discussed. In order to implement the practical in vivo or in vitro applications, the IONPs must have combined properties of high magnetic saturation, stability, biocompatibility, and interactive functions at the surface. Moreover, the surface of IONPs could be modified by organic materials or inorganic materials, such as polymers, biomolecules, silica, metals, etc. The new functionalized strategies, problems and major challenges, along with the current directions for the synthesis, surface functionalization and bioapplication of IONPs, are considered. Finally, some future trends and the prospects in these research areas are also discussed.

No MeSH data available.