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Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications

View Article: PubMed Central - PubMed

ABSTRACT

This review focuses on the recent development and various strategies in the preparation, microstructure, and magnetic properties of bare and surface functionalized iron oxide nanoparticles (IONPs); their corresponding biological application was also discussed. In order to implement the practical in vivo or in vitro applications, the IONPs must have combined properties of high magnetic saturation, stability, biocompatibility, and interactive functions at the surface. Moreover, the surface of IONPs could be modified by organic materials or inorganic materials, such as polymers, biomolecules, silica, metals, etc. The new functionalized strategies, problems and major challenges, along with the current directions for the synthesis, surface functionalization and bioapplication of IONPs, are considered. Finally, some future trends and the prospects in these research areas are also discussed.

No MeSH data available.


The XRD peak lines from standard powder diffraction files of α-Fe2O3 (33–0664), Fe3O4 (19–0629) and γ-Fe2O3 (39–1346).
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Figure 2: The XRD peak lines from standard powder diffraction files of α-Fe2O3 (33–0664), Fe3O4 (19–0629) and γ-Fe2O3 (39–1346).

Mentions: Figure 2 shows the x-ray diffraction (XRD) peak lines from the standard powder diffraction files of α-Fe2O3 (33–0664), Fe3O4 (19–0629) and γ-Fe2O3 (39–1346), and it can be found that γ-Fe2O3 has a crystal structure similar to that of Fe3O4. The diffractogram of the cubic form of γ-Fe2O3 is identical to that of Fe3O4 with some line shift towards higher angles. It is noteworthy that the annealing treatment is a key step in most synthesis of different crystalline phase iron oxides. Any type of iron oxide can be obtained from the other types by oxidizing or reducing the annealing treatment. Thus, the XRD patterns are a basic characterization technique for determining the crystal structure and types of magnetic IONPs.


Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications
The XRD peak lines from standard powder diffraction files of α-Fe2O3 (33–0664), Fe3O4 (19–0629) and γ-Fe2O3 (39–1346).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5036481&req=5

Figure 2: The XRD peak lines from standard powder diffraction files of α-Fe2O3 (33–0664), Fe3O4 (19–0629) and γ-Fe2O3 (39–1346).
Mentions: Figure 2 shows the x-ray diffraction (XRD) peak lines from the standard powder diffraction files of α-Fe2O3 (33–0664), Fe3O4 (19–0629) and γ-Fe2O3 (39–1346), and it can be found that γ-Fe2O3 has a crystal structure similar to that of Fe3O4. The diffractogram of the cubic form of γ-Fe2O3 is identical to that of Fe3O4 with some line shift towards higher angles. It is noteworthy that the annealing treatment is a key step in most synthesis of different crystalline phase iron oxides. Any type of iron oxide can be obtained from the other types by oxidizing or reducing the annealing treatment. Thus, the XRD patterns are a basic characterization technique for determining the crystal structure and types of magnetic IONPs.

View Article: PubMed Central - PubMed

ABSTRACT

This review focuses on the recent development and various strategies in the preparation, microstructure, and magnetic properties of bare and surface functionalized iron oxide nanoparticles (IONPs); their corresponding biological application was also discussed. In order to implement the practical in vivo or in vitro applications, the IONPs must have combined properties of high magnetic saturation, stability, biocompatibility, and interactive functions at the surface. Moreover, the surface of IONPs could be modified by organic materials or inorganic materials, such as polymers, biomolecules, silica, metals, etc. The new functionalized strategies, problems and major challenges, along with the current directions for the synthesis, surface functionalization and bioapplication of IONPs, are considered. Finally, some future trends and the prospects in these research areas are also discussed.

No MeSH data available.