Limits...
Imaging and Clinical Data of Placental Site Trophoblastic Tumor: A Case Report

View Article: PubMed Central - PubMed

ABSTRACT

Placental site trophoblastic tumor (PSTT) is a very rare variant of gestational trophoblastic tumor. It can occur after normal termination of pregnancy or spontaneous abortion and ectopic or molar pregnancy. There is a wide range of clinical manifestations from a benign condition to an aggressive disease with fatal outcome. One of the most important characteristics of PSTT, unlike other forms of gestational trophoblastic diseases (GTD) is the presence of low beta-subunit of human chorionic gonadotropin (β-hCG) levels because it is a neoplastic proliferation of intermediate trophoblastic cells. However, human placental lactogen (hPL) is increased on histologic section and in the serum of patients too. We present a case of PSTT and discuss the differential diagnosis in order to further familiarize physicians with the diagnosis and treatment of this disease. It has a varied clinical spectrum and usually presents with irregular vaginal bleeding or amenorrhea. Diagnosis is confirmed by dilatation and curettage (D and C) and hysterectomy. Because chemotherapy is not effective, surgery is the cornerstone of treatment. This case is presented because it is a rare neoplasm with different treatments and it should be differentiated from molar pregnancy.

No MeSH data available.


Related in: MedlinePlus

Color Doppler sonography depicts hypervascularity in the area of the tumor.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC5036456&req=5

fig32509: Color Doppler sonography depicts hypervascularity in the area of the tumor.

Mentions: Then after she underwent transvaginal ultrasonography (TVUS), a depicted heterogenic and irregular ill-defined mass lesion (37 × 29 mm) invading the anterior wall of the uterus body was detected. Uterine dimensions were 73 × 43 × 57 mm with a global shape. In the uterus, a tumorous mass was found that extended to about half of the myometrium. A thin endometrial line was seen indistinctly; therefore, differentiation between myometrium and endometrium was difficult (Figure 2). On color Doppler examination, the mass was hypervascular (Figure 3). Magnetic resonance imaging (MRI) revealed an indistinct moderate size, heterogonous mass lesion in the anterior wall of the uterus with a thin endometrium (Figure 4).


Imaging and Clinical Data of Placental Site Trophoblastic Tumor: A Case Report
Color Doppler sonography depicts hypervascularity in the area of the tumor.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5036456&req=5

fig32509: Color Doppler sonography depicts hypervascularity in the area of the tumor.
Mentions: Then after she underwent transvaginal ultrasonography (TVUS), a depicted heterogenic and irregular ill-defined mass lesion (37 × 29 mm) invading the anterior wall of the uterus body was detected. Uterine dimensions were 73 × 43 × 57 mm with a global shape. In the uterus, a tumorous mass was found that extended to about half of the myometrium. A thin endometrial line was seen indistinctly; therefore, differentiation between myometrium and endometrium was difficult (Figure 2). On color Doppler examination, the mass was hypervascular (Figure 3). Magnetic resonance imaging (MRI) revealed an indistinct moderate size, heterogonous mass lesion in the anterior wall of the uterus with a thin endometrium (Figure 4).

View Article: PubMed Central - PubMed

ABSTRACT

Placental site trophoblastic tumor (PSTT) is a very rare variant of gestational trophoblastic tumor. It can occur after normal termination of pregnancy or spontaneous abortion and ectopic or molar pregnancy. There is a wide range of clinical manifestations from a benign condition to an aggressive disease with fatal outcome. One of the most important characteristics of PSTT, unlike other forms of gestational trophoblastic diseases (GTD) is the presence of low beta-subunit of human chorionic gonadotropin (β-hCG) levels because it is a neoplastic proliferation of intermediate trophoblastic cells. However, human placental lactogen (hPL) is increased on histologic section and in the serum of patients too. We present a case of PSTT and discuss the differential diagnosis in order to further familiarize physicians with the diagnosis and treatment of this disease. It has a varied clinical spectrum and usually presents with irregular vaginal bleeding or amenorrhea. Diagnosis is confirmed by dilatation and curettage (D and C) and hysterectomy. Because chemotherapy is not effective, surgery is the cornerstone of treatment. This case is presented because it is a rare neoplasm with different treatments and it should be differentiated from molar pregnancy.

No MeSH data available.


Related in: MedlinePlus