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A review of novel analytical diagnostics for liquid biopsies: spectroscopic and spectrometric serum profiling of primary and secondary brain tumors

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ABSTRACT

Introduction: Spectroscopic and spectrometric analysis of biological samples is regarded as quick, cost effective, easy to operate, and spectroscopic sample preparation involves minimal sample preparation.

Results: Techniques like infrared (IR) spectroscopy, surface‐enhanced laser desorption/ionization (SELDI)‐mass spectroscopy (MS), and matrix‐assisted laser desorption/ionization (MALDI) ‐MS could enable early diagnosis of cancer, disease monitoring, and assessment of treatment responses allowing refinement, if required.

Discussion: Carrying out analytical testing within outpatient clinics would dramatically cut the time spent by patients attending different appointments, at different locations, save hospital time and resources but importantly would theoretically enable a reduction in mortality and morbidity. While the advantages of such a prospect seem obvious, this review aims to evaluate the use of human serum spectroscopic and spectrometric analysis as a diagnostic tool for brain cancers, creating a platform for the future of cancer diagnostics.

No MeSH data available.


Schematic showing the potential use of serum spectroscopy within a clinical setting [Figure adapted from (Hughes and Baker 2016)].
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brb3502-fig-0003: Schematic showing the potential use of serum spectroscopy within a clinical setting [Figure adapted from (Hughes and Baker 2016)].

Mentions: However, the multiple advantages of using IR spectroscopy within clinics allow future research to involve validation and translation into clinical environments, taking into consideration all preanalytical factors that could jeopardize approval and limit clinical applications. Hand held instrumentation would allow spectra to be acquired within the clinic, significantly decreasing diagnosis time, improving patient treatment and management, and enable effective use of healthcare time and resources (Popescu 2010). Dorling and Baker, presented a schematic highlighting the potential for serum analysis using spectroscopy within a clinical environment, expanded further by Hughes et al. (2016) (Hughes and Baker 2016) – see Figure 3.


A review of novel analytical diagnostics for liquid biopsies: spectroscopic and spectrometric serum profiling of primary and secondary brain tumors
Schematic showing the potential use of serum spectroscopy within a clinical setting [Figure adapted from (Hughes and Baker 2016)].
© Copyright Policy - creativeCommonsBy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5036428&req=5

brb3502-fig-0003: Schematic showing the potential use of serum spectroscopy within a clinical setting [Figure adapted from (Hughes and Baker 2016)].
Mentions: However, the multiple advantages of using IR spectroscopy within clinics allow future research to involve validation and translation into clinical environments, taking into consideration all preanalytical factors that could jeopardize approval and limit clinical applications. Hand held instrumentation would allow spectra to be acquired within the clinic, significantly decreasing diagnosis time, improving patient treatment and management, and enable effective use of healthcare time and resources (Popescu 2010). Dorling and Baker, presented a schematic highlighting the potential for serum analysis using spectroscopy within a clinical environment, expanded further by Hughes et al. (2016) (Hughes and Baker 2016) – see Figure 3.

View Article: PubMed Central - PubMed

ABSTRACT

Introduction: Spectroscopic and spectrometric analysis of biological samples is regarded as quick, cost effective, easy to operate, and spectroscopic sample preparation involves minimal sample preparation.

Results: Techniques like infrared (IR) spectroscopy, surface‐enhanced laser desorption/ionization (SELDI)‐mass spectroscopy (MS), and matrix‐assisted laser desorption/ionization (MALDI) ‐MS could enable early diagnosis of cancer, disease monitoring, and assessment of treatment responses allowing refinement, if required.

Discussion: Carrying out analytical testing within outpatient clinics would dramatically cut the time spent by patients attending different appointments, at different locations, save hospital time and resources but importantly would theoretically enable a reduction in mortality and morbidity. While the advantages of such a prospect seem obvious, this review aims to evaluate the use of human serum spectroscopic and spectrometric analysis as a diagnostic tool for brain cancers, creating a platform for the future of cancer diagnostics.

No MeSH data available.