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A review of novel analytical diagnostics for liquid biopsies: spectroscopic and spectrometric serum profiling of primary and secondary brain tumors

View Article: PubMed Central - PubMed

ABSTRACT

Introduction: Spectroscopic and spectrometric analysis of biological samples is regarded as quick, cost effective, easy to operate, and spectroscopic sample preparation involves minimal sample preparation.

Results: Techniques like infrared (IR) spectroscopy, surface‐enhanced laser desorption/ionization (SELDI)‐mass spectroscopy (MS), and matrix‐assisted laser desorption/ionization (MALDI) ‐MS could enable early diagnosis of cancer, disease monitoring, and assessment of treatment responses allowing refinement, if required.

Discussion: Carrying out analytical testing within outpatient clinics would dramatically cut the time spent by patients attending different appointments, at different locations, save hospital time and resources but importantly would theoretically enable a reduction in mortality and morbidity. While the advantages of such a prospect seem obvious, this review aims to evaluate the use of human serum spectroscopic and spectrometric analysis as a diagnostic tool for brain cancers, creating a platform for the future of cancer diagnostics.

No MeSH data available.


Related in: MedlinePlus

Pathways leading to the diagnosis of malignant gliomas. [Figure adapted from (Wen and Kesari 2008)].
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brb3502-fig-0001: Pathways leading to the diagnosis of malignant gliomas. [Figure adapted from (Wen and Kesari 2008)].

Mentions: Brain tumors form when normal cells within the brain mutate, grow uncontrollably and form a mass. Brain tumors are stratified into increasing grades of malignancy determined by how they are likely to grow, the likelihood of reoccurrence, and the likely best treatment, highlighted in Figure 1 (Wen and Kesari 2008). Gliomas occurring from the glial cells within the brain and central nervous system (CNS) (Hands et al. 2014) are the most common primary brain tumor classified by World Health Organisation (WHO) (Louis et al. 2007). Gliomas are often diagnosed late, are hard to treat, and the prognosis is poor. Generally, only 40% of patients with brain tumors are alive more than 1 year after diagnosis (Cancer Research UK). Traditional treatment involves surgery, radiation therapy, and chemotherapy but even with an extensive treatment plan survival is poor as symptoms are often diagnosed too late. The most common tumor types; astrocytomas, ependymomas, and oligodendrogliomas have very different outcomes.


A review of novel analytical diagnostics for liquid biopsies: spectroscopic and spectrometric serum profiling of primary and secondary brain tumors
Pathways leading to the diagnosis of malignant gliomas. [Figure adapted from (Wen and Kesari 2008)].
© Copyright Policy - creativeCommonsBy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5036428&req=5

brb3502-fig-0001: Pathways leading to the diagnosis of malignant gliomas. [Figure adapted from (Wen and Kesari 2008)].
Mentions: Brain tumors form when normal cells within the brain mutate, grow uncontrollably and form a mass. Brain tumors are stratified into increasing grades of malignancy determined by how they are likely to grow, the likelihood of reoccurrence, and the likely best treatment, highlighted in Figure 1 (Wen and Kesari 2008). Gliomas occurring from the glial cells within the brain and central nervous system (CNS) (Hands et al. 2014) are the most common primary brain tumor classified by World Health Organisation (WHO) (Louis et al. 2007). Gliomas are often diagnosed late, are hard to treat, and the prognosis is poor. Generally, only 40% of patients with brain tumors are alive more than 1 year after diagnosis (Cancer Research UK). Traditional treatment involves surgery, radiation therapy, and chemotherapy but even with an extensive treatment plan survival is poor as symptoms are often diagnosed too late. The most common tumor types; astrocytomas, ependymomas, and oligodendrogliomas have very different outcomes.

View Article: PubMed Central - PubMed

ABSTRACT

Introduction: Spectroscopic and spectrometric analysis of biological samples is regarded as quick, cost effective, easy to operate, and spectroscopic sample preparation involves minimal sample preparation.

Results: Techniques like infrared (IR) spectroscopy, surface‐enhanced laser desorption/ionization (SELDI)‐mass spectroscopy (MS), and matrix‐assisted laser desorption/ionization (MALDI) ‐MS could enable early diagnosis of cancer, disease monitoring, and assessment of treatment responses allowing refinement, if required.

Discussion: Carrying out analytical testing within outpatient clinics would dramatically cut the time spent by patients attending different appointments, at different locations, save hospital time and resources but importantly would theoretically enable a reduction in mortality and morbidity. While the advantages of such a prospect seem obvious, this review aims to evaluate the use of human serum spectroscopic and spectrometric analysis as a diagnostic tool for brain cancers, creating a platform for the future of cancer diagnostics.

No MeSH data available.


Related in: MedlinePlus