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Magnetic resonance imaging spectrum of perinatal hypoxic-ischemic brain injury

View Article: PubMed Central - PubMed

ABSTRACT

Perinatal hypoxic–ischemic brain injury results in neonatal hypoxic–ischemic encephalopathy and serious long-term neurodevelopmental sequelae. Magnetic resonance imaging (MRI) of the brain is an ideal and safe imaging modality for suspected hypoxic–ischemic injury. The pattern of injury depends on brain maturity at the time of insult, severity of hypotension, and duration of insult. Time of imaging after the insult influences the imaging findings. Mild to moderate hypoperfusion results in germinal matrix hemorrhages and periventricular leukomalacia in preterm neonates and parasagittal watershed territory infarcts in full-term neonates. Severe insult preferentially damages the deep gray matter in both term and preterm infants. However, associated frequent perirolandic injury is seen in term neonates. MRI is useful in establishing the clinical diagnosis, assessing the severity of injury, and thereby prognosticating the outcome. Familiarity with imaging spectrum and insight into factors affecting the injury will enlighten the radiologist to provide an appropriate diagnosis.

No MeSH data available.


Related in: MedlinePlus

A 20-day-old full-term neonate presenting with seizures shows mild hypoxic ischemic brain injury. Axial T1 (A) and T2 (B) WI at the level of lateral ventricles show few punctuate T1 hyperintensities (large black arrows) and subtle T2 hypointensities (small black arrows) representing astrogliosis in the parasagittal subcortical white matter. No blooming in the gradient images rules out hemorrhage
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Figure 16: A 20-day-old full-term neonate presenting with seizures shows mild hypoxic ischemic brain injury. Axial T1 (A) and T2 (B) WI at the level of lateral ventricles show few punctuate T1 hyperintensities (large black arrows) and subtle T2 hypointensities (small black arrows) representing astrogliosis in the parasagittal subcortical white matter. No blooming in the gradient images rules out hemorrhage


Magnetic resonance imaging spectrum of perinatal hypoxic-ischemic brain injury
A 20-day-old full-term neonate presenting with seizures shows mild hypoxic ischemic brain injury. Axial T1 (A) and T2 (B) WI at the level of lateral ventricles show few punctuate T1 hyperintensities (large black arrows) and subtle T2 hypointensities (small black arrows) representing astrogliosis in the parasagittal subcortical white matter. No blooming in the gradient images rules out hemorrhage
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5036328&req=5

Figure 16: A 20-day-old full-term neonate presenting with seizures shows mild hypoxic ischemic brain injury. Axial T1 (A) and T2 (B) WI at the level of lateral ventricles show few punctuate T1 hyperintensities (large black arrows) and subtle T2 hypointensities (small black arrows) representing astrogliosis in the parasagittal subcortical white matter. No blooming in the gradient images rules out hemorrhage

View Article: PubMed Central - PubMed

ABSTRACT

Perinatal hypoxic–ischemic brain injury results in neonatal hypoxic–ischemic encephalopathy and serious long-term neurodevelopmental sequelae. Magnetic resonance imaging (MRI) of the brain is an ideal and safe imaging modality for suspected hypoxic–ischemic injury. The pattern of injury depends on brain maturity at the time of insult, severity of hypotension, and duration of insult. Time of imaging after the insult influences the imaging findings. Mild to moderate hypoperfusion results in germinal matrix hemorrhages and periventricular leukomalacia in preterm neonates and parasagittal watershed territory infarcts in full-term neonates. Severe insult preferentially damages the deep gray matter in both term and preterm infants. However, associated frequent perirolandic injury is seen in term neonates. MRI is useful in establishing the clinical diagnosis, assessing the severity of injury, and thereby prognosticating the outcome. Familiarity with imaging spectrum and insight into factors affecting the injury will enlighten the radiologist to provide an appropriate diagnosis.

No MeSH data available.


Related in: MedlinePlus