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Coffee and cancer risk: A meta-analysis of prospective observational studies

View Article: PubMed Central - PubMed

ABSTRACT

Meta-analyses on coffee and cancer incidence mainly restricted to limited cancers. We carried out a more comprehensive meta-analysis of cohort studies to explore association between coffee and most cancer types. We conducted comprehensive search and summarized relative risk (RR) and 95% confidence intervals for the highest versus lowest coffee intake and cancer using STATA12. We conducted dose-analysis if result suggested significant association. The publication bias was evaluated with begg’s and egger’s test. Finally, 105 individual prospective studies were included. Inverse associations were observed on oral, pharyngeal, colon, liver, prostate, endometrial cancer and melanoma, with RR 0.69 (95% CI = 0.48–0.99, I2 = 73.4%, P = 0.044), 0.87 (95% CI = 0.78–0.96, I2 = 28.4%, P = 0.007), 0.46 (95% CI = 0.37–0.57, I2 = 0%, P = 0), 0.89 (95% CI = 0.84–0.93, I2 = 30.3%, P = 0.003), 0.73 (95% CI = 0.67–0.80, I2  = 0%, P = 0) and 0.89 (95% CI = 0.80–0.99, I2  = 0%, P = 0.031) respectively. However, the relative risk for lung cancer is 2.18 (95% CI = 1.26–3.75, I2  = 63.3%, P = 0.005). The summary relative risk for increment of 2 cups of coffee were RR = 0.73, 95% CI = 0.67–0.79 for liver cancer, RR = 0.97, 95% CI = 0.96–0.98 for prostate cancer and RR = 0.88, 95% CI = 0.85–0.92 for endometrial cancer. Accordingly, coffee intake was associated with reduced risk of oral, pharynx, liver, colon, prostate, endometrial cancer and melanoma and increased lung cancer risk.

No MeSH data available.


Related in: MedlinePlus

Meta-analyses between coffee intake and risk of lymphoma.Relative risks of lymphoma associated with coffee intake. Squares represent study-specific relative risk estimates (size of the square reflects the study-specific statistical weigh, that is, the inverse of the variance); horizontal lines represent 95% CIs; diamonds represent summary relative risk estimates with corresponding 95% CIs.
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f8: Meta-analyses between coffee intake and risk of lymphoma.Relative risks of lymphoma associated with coffee intake. Squares represent study-specific relative risk estimates (size of the square reflects the study-specific statistical weigh, that is, the inverse of the variance); horizontal lines represent 95% CIs; diamonds represent summary relative risk estimates with corresponding 95% CIs.

Mentions: Highest versus lowest intake: Three cohort studies303143 were included in the analysis (89897 samples) of the highest group (samples/cases: 32783/63) versus lowest group (samples/cases: 17229/22) coffee intake and lymphoma. The study characteristics are presented (Stable 4a). The summary RR was 1.23 (95% CI = 0.75–2.03, P = 0.415) with no heterogeneity (I2 = 0%, P = 0.769) (Fig. 8). The results suggest no publication bias, with P = 1 for Begg’s test and P = 0.18 for Egger’s test.


Coffee and cancer risk: A meta-analysis of prospective observational studies
Meta-analyses between coffee intake and risk of lymphoma.Relative risks of lymphoma associated with coffee intake. Squares represent study-specific relative risk estimates (size of the square reflects the study-specific statistical weigh, that is, the inverse of the variance); horizontal lines represent 95% CIs; diamonds represent summary relative risk estimates with corresponding 95% CIs.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5036059&req=5

f8: Meta-analyses between coffee intake and risk of lymphoma.Relative risks of lymphoma associated with coffee intake. Squares represent study-specific relative risk estimates (size of the square reflects the study-specific statistical weigh, that is, the inverse of the variance); horizontal lines represent 95% CIs; diamonds represent summary relative risk estimates with corresponding 95% CIs.
Mentions: Highest versus lowest intake: Three cohort studies303143 were included in the analysis (89897 samples) of the highest group (samples/cases: 32783/63) versus lowest group (samples/cases: 17229/22) coffee intake and lymphoma. The study characteristics are presented (Stable 4a). The summary RR was 1.23 (95% CI = 0.75–2.03, P = 0.415) with no heterogeneity (I2 = 0%, P = 0.769) (Fig. 8). The results suggest no publication bias, with P = 1 for Begg’s test and P = 0.18 for Egger’s test.

View Article: PubMed Central - PubMed

ABSTRACT

Meta-analyses on coffee and cancer incidence mainly restricted to limited cancers. We carried out a more comprehensive meta-analysis of cohort studies to explore association between coffee and most cancer types. We conducted comprehensive search and summarized relative risk (RR) and 95% confidence intervals for the highest versus lowest coffee intake and cancer using STATA12. We conducted dose-analysis if result suggested significant association. The publication bias was evaluated with begg’s and egger’s test. Finally, 105 individual prospective studies were included. Inverse associations were observed on oral, pharyngeal, colon, liver, prostate, endometrial cancer and melanoma, with RR 0.69 (95% CI = 0.48–0.99, I2 = 73.4%, P = 0.044), 0.87 (95% CI = 0.78–0.96, I2 = 28.4%, P = 0.007), 0.46 (95% CI = 0.37–0.57, I2 = 0%, P = 0), 0.89 (95% CI = 0.84–0.93, I2 = 30.3%, P = 0.003), 0.73 (95% CI = 0.67–0.80, I2  = 0%, P = 0) and 0.89 (95% CI = 0.80–0.99, I2  = 0%, P = 0.031) respectively. However, the relative risk for lung cancer is 2.18 (95% CI = 1.26–3.75, I2  = 63.3%, P = 0.005). The summary relative risk for increment of 2 cups of coffee were RR = 0.73, 95% CI = 0.67–0.79 for liver cancer, RR = 0.97, 95% CI = 0.96–0.98 for prostate cancer and RR = 0.88, 95% CI = 0.85–0.92 for endometrial cancer. Accordingly, coffee intake was associated with reduced risk of oral, pharynx, liver, colon, prostate, endometrial cancer and melanoma and increased lung cancer risk.

No MeSH data available.


Related in: MedlinePlus