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Coffee and cancer risk: A meta-analysis of prospective observational studies

View Article: PubMed Central - PubMed

ABSTRACT

Meta-analyses on coffee and cancer incidence mainly restricted to limited cancers. We carried out a more comprehensive meta-analysis of cohort studies to explore association between coffee and most cancer types. We conducted comprehensive search and summarized relative risk (RR) and 95% confidence intervals for the highest versus lowest coffee intake and cancer using STATA12. We conducted dose-analysis if result suggested significant association. The publication bias was evaluated with begg’s and egger’s test. Finally, 105 individual prospective studies were included. Inverse associations were observed on oral, pharyngeal, colon, liver, prostate, endometrial cancer and melanoma, with RR 0.69 (95% CI = 0.48–0.99, I2 = 73.4%, P = 0.044), 0.87 (95% CI = 0.78–0.96, I2 = 28.4%, P = 0.007), 0.46 (95% CI = 0.37–0.57, I2 = 0%, P = 0), 0.89 (95% CI = 0.84–0.93, I2 = 30.3%, P = 0.003), 0.73 (95% CI = 0.67–0.80, I2  = 0%, P = 0) and 0.89 (95% CI = 0.80–0.99, I2  = 0%, P = 0.031) respectively. However, the relative risk for lung cancer is 2.18 (95% CI = 1.26–3.75, I2  = 63.3%, P = 0.005). The summary relative risk for increment of 2 cups of coffee were RR = 0.73, 95% CI = 0.67–0.79 for liver cancer, RR = 0.97, 95% CI = 0.96–0.98 for prostate cancer and RR = 0.88, 95% CI = 0.85–0.92 for endometrial cancer. Accordingly, coffee intake was associated with reduced risk of oral, pharynx, liver, colon, prostate, endometrial cancer and melanoma and increased lung cancer risk.

No MeSH data available.


Related in: MedlinePlus

Dose-response analyses between coffee intake and risk of liver cancer, prostate cancer and endometrial cancer.Relative risks of liver cancer (A), prostate cancer (B) and endometrial cancer (C) associated with coffee intake. Squares represent study-specific relative risk estimates (size of the square reflects the study-specific statistical weigh, that is, the inverse of the variance); horizontal lines represent 95% CIs; diamonds represent summary relative risk estimates with corresponding 95% CIs.
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f5: Dose-response analyses between coffee intake and risk of liver cancer, prostate cancer and endometrial cancer.Relative risks of liver cancer (A), prostate cancer (B) and endometrial cancer (C) associated with coffee intake. Squares represent study-specific relative risk estimates (size of the square reflects the study-specific statistical weigh, that is, the inverse of the variance); horizontal lines represent 95% CIs; diamonds represent summary relative risk estimates with corresponding 95% CIs.

Mentions: Highest versus lowest intake: Nine cohort studies237576777879808182 were included in the analysis (968517 samples) of the highest versus lowest intake of coffee and liver cancer. The study characteristics are presented (Stable 1a). The summary RR was 0.46 (95% CI = 0.37–0.57, P = 0) with no heterogeneity (I2 = 0%, P = 0.44) (Fig. 5A). The results suggest no publication bias, with P = 0.18 for Begg’s test and P = 0.23 for Egger’s test. The inverse association was observed between coffee consumption and liver cancer incidence in most subgroups through subgroup analysis. However, there was no significant relationship between coffee intake and the risk of liver cancer in women subgroup (Stable 1b).


Coffee and cancer risk: A meta-analysis of prospective observational studies
Dose-response analyses between coffee intake and risk of liver cancer, prostate cancer and endometrial cancer.Relative risks of liver cancer (A), prostate cancer (B) and endometrial cancer (C) associated with coffee intake. Squares represent study-specific relative risk estimates (size of the square reflects the study-specific statistical weigh, that is, the inverse of the variance); horizontal lines represent 95% CIs; diamonds represent summary relative risk estimates with corresponding 95% CIs.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5036059&req=5

f5: Dose-response analyses between coffee intake and risk of liver cancer, prostate cancer and endometrial cancer.Relative risks of liver cancer (A), prostate cancer (B) and endometrial cancer (C) associated with coffee intake. Squares represent study-specific relative risk estimates (size of the square reflects the study-specific statistical weigh, that is, the inverse of the variance); horizontal lines represent 95% CIs; diamonds represent summary relative risk estimates with corresponding 95% CIs.
Mentions: Highest versus lowest intake: Nine cohort studies237576777879808182 were included in the analysis (968517 samples) of the highest versus lowest intake of coffee and liver cancer. The study characteristics are presented (Stable 1a). The summary RR was 0.46 (95% CI = 0.37–0.57, P = 0) with no heterogeneity (I2 = 0%, P = 0.44) (Fig. 5A). The results suggest no publication bias, with P = 0.18 for Begg’s test and P = 0.23 for Egger’s test. The inverse association was observed between coffee consumption and liver cancer incidence in most subgroups through subgroup analysis. However, there was no significant relationship between coffee intake and the risk of liver cancer in women subgroup (Stable 1b).

View Article: PubMed Central - PubMed

ABSTRACT

Meta-analyses on coffee and cancer incidence mainly restricted to limited cancers. We carried out a more comprehensive meta-analysis of cohort studies to explore association between coffee and most cancer types. We conducted comprehensive search and summarized relative risk (RR) and 95% confidence intervals for the highest versus lowest coffee intake and cancer using STATA12. We conducted dose-analysis if result suggested significant association. The publication bias was evaluated with begg’s and egger’s test. Finally, 105 individual prospective studies were included. Inverse associations were observed on oral, pharyngeal, colon, liver, prostate, endometrial cancer and melanoma, with RR 0.69 (95% CI = 0.48–0.99, I2 = 73.4%, P = 0.044), 0.87 (95% CI = 0.78–0.96, I2 = 28.4%, P = 0.007), 0.46 (95% CI = 0.37–0.57, I2 = 0%, P = 0), 0.89 (95% CI = 0.84–0.93, I2 = 30.3%, P = 0.003), 0.73 (95% CI = 0.67–0.80, I2  = 0%, P = 0) and 0.89 (95% CI = 0.80–0.99, I2  = 0%, P = 0.031) respectively. However, the relative risk for lung cancer is 2.18 (95% CI = 1.26–3.75, I2  = 63.3%, P = 0.005). The summary relative risk for increment of 2 cups of coffee were RR = 0.73, 95% CI = 0.67–0.79 for liver cancer, RR = 0.97, 95% CI = 0.96–0.98 for prostate cancer and RR = 0.88, 95% CI = 0.85–0.92 for endometrial cancer. Accordingly, coffee intake was associated with reduced risk of oral, pharynx, liver, colon, prostate, endometrial cancer and melanoma and increased lung cancer risk.

No MeSH data available.


Related in: MedlinePlus