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Coffee and cancer risk: A meta-analysis of prospective observational studies

View Article: PubMed Central - PubMed

ABSTRACT

Meta-analyses on coffee and cancer incidence mainly restricted to limited cancers. We carried out a more comprehensive meta-analysis of cohort studies to explore association between coffee and most cancer types. We conducted comprehensive search and summarized relative risk (RR) and 95% confidence intervals for the highest versus lowest coffee intake and cancer using STATA12. We conducted dose-analysis if result suggested significant association. The publication bias was evaluated with begg’s and egger’s test. Finally, 105 individual prospective studies were included. Inverse associations were observed on oral, pharyngeal, colon, liver, prostate, endometrial cancer and melanoma, with RR 0.69 (95% CI = 0.48–0.99, I2 = 73.4%, P = 0.044), 0.87 (95% CI = 0.78–0.96, I2 = 28.4%, P = 0.007), 0.46 (95% CI = 0.37–0.57, I2 = 0%, P = 0), 0.89 (95% CI = 0.84–0.93, I2 = 30.3%, P = 0.003), 0.73 (95% CI = 0.67–0.80, I2  = 0%, P = 0) and 0.89 (95% CI = 0.80–0.99, I2  = 0%, P = 0.031) respectively. However, the relative risk for lung cancer is 2.18 (95% CI = 1.26–3.75, I2  = 63.3%, P = 0.005). The summary relative risk for increment of 2 cups of coffee were RR = 0.73, 95% CI = 0.67–0.79 for liver cancer, RR = 0.97, 95% CI = 0.96–0.98 for prostate cancer and RR = 0.88, 95% CI = 0.85–0.92 for endometrial cancer. Accordingly, coffee intake was associated with reduced risk of oral, pharynx, liver, colon, prostate, endometrial cancer and melanoma and increased lung cancer risk.

No MeSH data available.


Related in: MedlinePlus

Meta-analyses between coffee intake and risk of oral, pharynx cancer, colorectal cancer, lung cancer and melanoma.Relative risks of oral, pharynx cancer (A), colorectal cancer (B), lung cancer (C) and melanoma (D) associated with coffee intake. Squares represent study-specific relative risk estimates (size of the square reflects the study-specific statistical weigh, that is, the inverse of the variance); horizontal lines represent 95% CIs; diamonds represent summary relative risk estimates with corresponding 95% CIs.
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f2: Meta-analyses between coffee intake and risk of oral, pharynx cancer, colorectal cancer, lung cancer and melanoma.Relative risks of oral, pharynx cancer (A), colorectal cancer (B), lung cancer (C) and melanoma (D) associated with coffee intake. Squares represent study-specific relative risk estimates (size of the square reflects the study-specific statistical weigh, that is, the inverse of the variance); horizontal lines represent 95% CIs; diamonds represent summary relative risk estimates with corresponding 95% CIs.

Mentions: Highest versus lowest intake: Six cohort studies303132333435 were included in the analysis (1395309 samples) of the highest versus lowest intake of coffee and oral, pharynx cancer. The study characteristics are presented (Stable 1a). The summary RR was 0.69 (95% CI = 0.48–0.99, P = 0.044) with high heterogeneity (I2 = 73.4%, P = 0.002) (Fig. 2A). The results suggest no publication bias, with P = 1 for Begg’s test and P = 0.98 for Egger’s test. The subgroup analysis indicated that the inverse association was observed between coffee consumption and oral, pharynx cancer incidence in Asia and follow-up (>10 years) subgroup. The same relationship was observed in smoking adjustment subgroup, physical activity adjustment subgroup and total energy adjustment subgroup (Stable 1b).


Coffee and cancer risk: A meta-analysis of prospective observational studies
Meta-analyses between coffee intake and risk of oral, pharynx cancer, colorectal cancer, lung cancer and melanoma.Relative risks of oral, pharynx cancer (A), colorectal cancer (B), lung cancer (C) and melanoma (D) associated with coffee intake. Squares represent study-specific relative risk estimates (size of the square reflects the study-specific statistical weigh, that is, the inverse of the variance); horizontal lines represent 95% CIs; diamonds represent summary relative risk estimates with corresponding 95% CIs.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5036059&req=5

f2: Meta-analyses between coffee intake and risk of oral, pharynx cancer, colorectal cancer, lung cancer and melanoma.Relative risks of oral, pharynx cancer (A), colorectal cancer (B), lung cancer (C) and melanoma (D) associated with coffee intake. Squares represent study-specific relative risk estimates (size of the square reflects the study-specific statistical weigh, that is, the inverse of the variance); horizontal lines represent 95% CIs; diamonds represent summary relative risk estimates with corresponding 95% CIs.
Mentions: Highest versus lowest intake: Six cohort studies303132333435 were included in the analysis (1395309 samples) of the highest versus lowest intake of coffee and oral, pharynx cancer. The study characteristics are presented (Stable 1a). The summary RR was 0.69 (95% CI = 0.48–0.99, P = 0.044) with high heterogeneity (I2 = 73.4%, P = 0.002) (Fig. 2A). The results suggest no publication bias, with P = 1 for Begg’s test and P = 0.98 for Egger’s test. The subgroup analysis indicated that the inverse association was observed between coffee consumption and oral, pharynx cancer incidence in Asia and follow-up (>10 years) subgroup. The same relationship was observed in smoking adjustment subgroup, physical activity adjustment subgroup and total energy adjustment subgroup (Stable 1b).

View Article: PubMed Central - PubMed

ABSTRACT

Meta-analyses on coffee and cancer incidence mainly restricted to limited cancers. We carried out a more comprehensive meta-analysis of cohort studies to explore association between coffee and most cancer types. We conducted comprehensive search and summarized relative risk (RR) and 95% confidence intervals for the highest versus lowest coffee intake and cancer using STATA12. We conducted dose-analysis if result suggested significant association. The publication bias was evaluated with begg’s and egger’s test. Finally, 105 individual prospective studies were included. Inverse associations were observed on oral, pharyngeal, colon, liver, prostate, endometrial cancer and melanoma, with RR 0.69 (95% CI = 0.48–0.99, I2 = 73.4%, P = 0.044), 0.87 (95% CI = 0.78–0.96, I2 = 28.4%, P = 0.007), 0.46 (95% CI = 0.37–0.57, I2 = 0%, P = 0), 0.89 (95% CI = 0.84–0.93, I2 = 30.3%, P = 0.003), 0.73 (95% CI = 0.67–0.80, I2  = 0%, P = 0) and 0.89 (95% CI = 0.80–0.99, I2  = 0%, P = 0.031) respectively. However, the relative risk for lung cancer is 2.18 (95% CI = 1.26–3.75, I2  = 63.3%, P = 0.005). The summary relative risk for increment of 2 cups of coffee were RR = 0.73, 95% CI = 0.67–0.79 for liver cancer, RR = 0.97, 95% CI = 0.96–0.98 for prostate cancer and RR = 0.88, 95% CI = 0.85–0.92 for endometrial cancer. Accordingly, coffee intake was associated with reduced risk of oral, pharynx, liver, colon, prostate, endometrial cancer and melanoma and increased lung cancer risk.

No MeSH data available.


Related in: MedlinePlus