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Cognition and Visit-to-Visit Variability of Blood Pressure and Heart Rate in De Novo Patients with Parkinson ’ s Disease

View Article: PubMed Central - PubMed

ABSTRACT

Objective: We sought to identify whether the characteristics of long-term visit-to-visit blood pressure (BP) and heart rate (HR) are related to baseline cognitive profiles in, Parkinson’s disease (PD).

Methods: We selected drug-naïve PD patients who visited our hospital at least 10 times with a baseline assessment of the Seoul neuropsychological battery. BP and HR were measured at each visit, and the variability of the systolic BP/diastolic BP (DBP) and HR was derived from the parameters of serial 10 office visits. Mild cognitive impairment (MCI) in PD patients was determined according to the proposed criteria with a cut-off value of z-score ≤ -2.

Results: Forty-seven patients with PD (mean follow-up duration = 22.3 months) were enrolled in the study. Compared with non-MCI PD patients, MCI PD patients revealed a significant increase in HR and/or variability in DBP.

Conclusion: This exploratory study showed that baseline cognition in drug-naïve PD patients might be related to the visit-to-visit variability of DBP and/or HR.

No MeSH data available.


Related in: MedlinePlus

Visit-to-visit variability of blood pressure and HR between non-MCI and MCI in patients with Parkinson’s disease. A: Standard deviation (SD). B: Coefficient of variation (CV). *p < 0.1, †p < 0.05. SBP: systolic blood pressure, DBP: diastolic blood pressure, HR: heart rate, MCI: mild cognitive impairment.
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f2-jmd-16012: Visit-to-visit variability of blood pressure and HR between non-MCI and MCI in patients with Parkinson’s disease. A: Standard deviation (SD). B: Coefficient of variation (CV). *p < 0.1, †p < 0.05. SBP: systolic blood pressure, DBP: diastolic blood pressure, HR: heart rate, MCI: mild cognitive impairment.

Mentions: For the profiles of visit-to-visit SBP, DBP, and HR, the comparisons between the non-MCI and MCI group are shown in Table 2. The primary parameters of SBP, DBP, and HR including mean, maximum, and minimum vales were not different between the groups. The visit-to-visit variability of DBP and HR is shown in Table 3, Figure 2, and Supplementary Table 2 (in the online-only Data Supplement). ANCOVA in Table 3 exhibited not only a higher variability of visit-to-visit DBP (p = 0.042) but also a tendency of visit-to-visit HR variability (p = 0.078). As shown Figure 2, PD MCI patients revealed a tendency of higher variability of visit-to-visit DBP, compared with non-MCI patients (SD values of 7.6 ± 2.7 mm Hg vs. 6.4 ± 1.4 mm Hg, p = 0.057; CV values of 11.1 ± 4.0% vs. 9.4 ± 2.2%, p = 0.080, respectively). Moreover, the visit-to-visit HR variability was greater in patients with PD MCI (SD = 8.7 ± 4.2 mm Hg; CV = 11.1 ± 5.9%, respectively) than in those with PD non-MCI (SD = 6.4 ± 2.5 mm Hg, p = 0.027; CV = 8.0 ± 3.0%, p = 0.020, respectively). However, there was no difference in the visit-to-visit SBP variability between both of them.


Cognition and Visit-to-Visit Variability of Blood Pressure and Heart Rate in De Novo Patients with Parkinson ’ s Disease
Visit-to-visit variability of blood pressure and HR between non-MCI and MCI in patients with Parkinson’s disease. A: Standard deviation (SD). B: Coefficient of variation (CV). *p < 0.1, †p < 0.05. SBP: systolic blood pressure, DBP: diastolic blood pressure, HR: heart rate, MCI: mild cognitive impairment.
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Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC5035940&req=5

f2-jmd-16012: Visit-to-visit variability of blood pressure and HR between non-MCI and MCI in patients with Parkinson’s disease. A: Standard deviation (SD). B: Coefficient of variation (CV). *p < 0.1, †p < 0.05. SBP: systolic blood pressure, DBP: diastolic blood pressure, HR: heart rate, MCI: mild cognitive impairment.
Mentions: For the profiles of visit-to-visit SBP, DBP, and HR, the comparisons between the non-MCI and MCI group are shown in Table 2. The primary parameters of SBP, DBP, and HR including mean, maximum, and minimum vales were not different between the groups. The visit-to-visit variability of DBP and HR is shown in Table 3, Figure 2, and Supplementary Table 2 (in the online-only Data Supplement). ANCOVA in Table 3 exhibited not only a higher variability of visit-to-visit DBP (p = 0.042) but also a tendency of visit-to-visit HR variability (p = 0.078). As shown Figure 2, PD MCI patients revealed a tendency of higher variability of visit-to-visit DBP, compared with non-MCI patients (SD values of 7.6 ± 2.7 mm Hg vs. 6.4 ± 1.4 mm Hg, p = 0.057; CV values of 11.1 ± 4.0% vs. 9.4 ± 2.2%, p = 0.080, respectively). Moreover, the visit-to-visit HR variability was greater in patients with PD MCI (SD = 8.7 ± 4.2 mm Hg; CV = 11.1 ± 5.9%, respectively) than in those with PD non-MCI (SD = 6.4 ± 2.5 mm Hg, p = 0.027; CV = 8.0 ± 3.0%, p = 0.020, respectively). However, there was no difference in the visit-to-visit SBP variability between both of them.

View Article: PubMed Central - PubMed

ABSTRACT

Objective: We sought to identify whether the characteristics of long-term visit-to-visit blood pressure (BP) and heart rate (HR) are related to baseline cognitive profiles in, Parkinson&rsquo;s disease (PD).

Methods: We selected drug-na&iuml;ve PD patients who visited our hospital at least 10 times with a baseline assessment of the Seoul neuropsychological battery. BP and HR were measured at each visit, and the variability of the systolic BP/diastolic BP (DBP) and HR was derived from the parameters of serial 10 office visits. Mild cognitive impairment (MCI) in PD patients was determined according to the proposed criteria with a cut-off value of z-score &le; -2.

Results: Forty-seven patients with PD (mean follow-up duration = 22.3 months) were enrolled in the study. Compared with non-MCI PD patients, MCI PD patients revealed a significant increase in HR and/or variability in DBP.

Conclusion: This exploratory study showed that baseline cognition in drug-na&iuml;ve PD patients might be related to the visit-to-visit variability of DBP and/or HR.

No MeSH data available.


Related in: MedlinePlus