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Cognition and Visit-to-Visit Variability of Blood Pressure and Heart Rate in De Novo Patients with Parkinson ’ s Disease

View Article: PubMed Central - PubMed

ABSTRACT

Objective: We sought to identify whether the characteristics of long-term visit-to-visit blood pressure (BP) and heart rate (HR) are related to baseline cognitive profiles in, Parkinson’s disease (PD).

Methods: We selected drug-naïve PD patients who visited our hospital at least 10 times with a baseline assessment of the Seoul neuropsychological battery. BP and HR were measured at each visit, and the variability of the systolic BP/diastolic BP (DBP) and HR was derived from the parameters of serial 10 office visits. Mild cognitive impairment (MCI) in PD patients was determined according to the proposed criteria with a cut-off value of z-score ≤ -2.

Results: Forty-seven patients with PD (mean follow-up duration = 22.3 months) were enrolled in the study. Compared with non-MCI PD patients, MCI PD patients revealed a significant increase in HR and/or variability in DBP.

Conclusion: This exploratory study showed that baseline cognition in drug-naïve PD patients might be related to the visit-to-visit variability of DBP and/or HR.

No MeSH data available.


Related in: MedlinePlus

Cognitive profiles of de novo Parkinson’s disease (PD) with mild cognitive impairment (MCI) in the study.
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f1-jmd-16012: Cognitive profiles of de novo Parkinson’s disease (PD) with mild cognitive impairment (MCI) in the study.

Mentions: Based on neuropsychological data described in Supplementary Table 1 (in the online-only Data Supplement), subtype classification was performed in the study population. The cognitive profiles of patients were distributed as shown in Figure 1: 45% (21 of 47 patients) with normal cognition, 28% (13 of 47) with non-amnestic single-domain MCI, 19% (9 of 47) with multiple-domain MCI, and 8% (4 of 47) with amnestic single-domain MCI.


Cognition and Visit-to-Visit Variability of Blood Pressure and Heart Rate in De Novo Patients with Parkinson ’ s Disease
Cognitive profiles of de novo Parkinson’s disease (PD) with mild cognitive impairment (MCI) in the study.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5035940&req=5

f1-jmd-16012: Cognitive profiles of de novo Parkinson’s disease (PD) with mild cognitive impairment (MCI) in the study.
Mentions: Based on neuropsychological data described in Supplementary Table 1 (in the online-only Data Supplement), subtype classification was performed in the study population. The cognitive profiles of patients were distributed as shown in Figure 1: 45% (21 of 47 patients) with normal cognition, 28% (13 of 47) with non-amnestic single-domain MCI, 19% (9 of 47) with multiple-domain MCI, and 8% (4 of 47) with amnestic single-domain MCI.

View Article: PubMed Central - PubMed

ABSTRACT

Objective: We sought to identify whether the characteristics of long-term visit-to-visit blood pressure (BP) and heart rate (HR) are related to baseline cognitive profiles in, Parkinson’s disease (PD).

Methods: We selected drug-naïve PD patients who visited our hospital at least 10 times with a baseline assessment of the Seoul neuropsychological battery. BP and HR were measured at each visit, and the variability of the systolic BP/diastolic BP (DBP) and HR was derived from the parameters of serial 10 office visits. Mild cognitive impairment (MCI) in PD patients was determined according to the proposed criteria with a cut-off value of z-score ≤ -2.

Results: Forty-seven patients with PD (mean follow-up duration = 22.3 months) were enrolled in the study. Compared with non-MCI PD patients, MCI PD patients revealed a significant increase in HR and/or variability in DBP.

Conclusion: This exploratory study showed that baseline cognition in drug-naïve PD patients might be related to the visit-to-visit variability of DBP and/or HR.

No MeSH data available.


Related in: MedlinePlus