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A unique dedifferentiated tumor of the retroperitoneum.

Karmali S, Benediktson H, Temple W, Bathe OF - World J Surg Oncol (2004)

Bottom Line: A 19.8 kg heterogeneous retroperitoneal tumor was successfully and completely resected.The recurrent tumor differed from the primary tumor in that it was more homogeneous, consisting mainly of nonlipogenic, calcific tissue.Dedifferentiated liposarcomas are known to have a very high recurrence rate.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Surgery, University of Calgary, Calgary, AB, Canada. karmalis@ucalgary.ca

ABSTRACT

Background: Dedifferentiated liposarcomas represent heterogeneous tumors with lipomatous and nonlipomatous elements starkly juxtaposed. It is thought that the high grade nonlipomatous elements of the tumor portend a worse prognosis.

Case presentation: A 19.8 kg heterogeneous retroperitoneal tumor was successfully and completely resected. Because of its extent, no additional treatment modalities were practicable. The tumor soon recurred. The recurrent tumor differed from the primary tumor in that it was more homogeneous, consisting mainly of nonlipogenic, calcific tissue.

Conclusions: Dedifferentiated liposarcomas are known to have a very high recurrence rate. The biological behavior of dedifferentiated liposarcomas is likely dictated by the most aggressive element of these heterogeneous tumors.

No MeSH data available.


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Histologic appearance of various elements of the tumor as sampled in different regions. A. Well differentiated liposarcoma. B. Low grade spindle cell component. C. Cellular spindle cell component. D. Chondrosarcomatous component.
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Figure 4: Histologic appearance of various elements of the tumor as sampled in different regions. A. Well differentiated liposarcoma. B. Low grade spindle cell component. C. Cellular spindle cell component. D. Chondrosarcomatous component.

Mentions: The tumor was submitted for histological examination in two parts measuring, 30.0 × 10.0 × 6.5 cm and 32.0 × 20.0 × 10.0 cm, weighing 19.8 kg in total (Figure 3). On gross examination the mass was variegated, with fleshy and solid cystic degeneration containing areas of osseous consistency. Microscopic examination revealed a juxtaposition of well differentiated liposarcoma and a spindle cell sarcoma with heterologous chondrosarcomatous elements consistent with a dedifferentiated liposarcoma (Figure 4).


A unique dedifferentiated tumor of the retroperitoneum.

Karmali S, Benediktson H, Temple W, Bathe OF - World J Surg Oncol (2004)

Histologic appearance of various elements of the tumor as sampled in different regions. A. Well differentiated liposarcoma. B. Low grade spindle cell component. C. Cellular spindle cell component. D. Chondrosarcomatous component.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC503399&req=5

Figure 4: Histologic appearance of various elements of the tumor as sampled in different regions. A. Well differentiated liposarcoma. B. Low grade spindle cell component. C. Cellular spindle cell component. D. Chondrosarcomatous component.
Mentions: The tumor was submitted for histological examination in two parts measuring, 30.0 × 10.0 × 6.5 cm and 32.0 × 20.0 × 10.0 cm, weighing 19.8 kg in total (Figure 3). On gross examination the mass was variegated, with fleshy and solid cystic degeneration containing areas of osseous consistency. Microscopic examination revealed a juxtaposition of well differentiated liposarcoma and a spindle cell sarcoma with heterologous chondrosarcomatous elements consistent with a dedifferentiated liposarcoma (Figure 4).

Bottom Line: A 19.8 kg heterogeneous retroperitoneal tumor was successfully and completely resected.The recurrent tumor differed from the primary tumor in that it was more homogeneous, consisting mainly of nonlipogenic, calcific tissue.Dedifferentiated liposarcomas are known to have a very high recurrence rate.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Surgery, University of Calgary, Calgary, AB, Canada. karmalis@ucalgary.ca

ABSTRACT

Background: Dedifferentiated liposarcomas represent heterogeneous tumors with lipomatous and nonlipomatous elements starkly juxtaposed. It is thought that the high grade nonlipomatous elements of the tumor portend a worse prognosis.

Case presentation: A 19.8 kg heterogeneous retroperitoneal tumor was successfully and completely resected. Because of its extent, no additional treatment modalities were practicable. The tumor soon recurred. The recurrent tumor differed from the primary tumor in that it was more homogeneous, consisting mainly of nonlipogenic, calcific tissue.

Conclusions: Dedifferentiated liposarcomas are known to have a very high recurrence rate. The biological behavior of dedifferentiated liposarcomas is likely dictated by the most aggressive element of these heterogeneous tumors.

No MeSH data available.


Related in: MedlinePlus