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A unique dedifferentiated tumor of the retroperitoneum.

Karmali S, Benediktson H, Temple W, Bathe OF - World J Surg Oncol (2004)

Bottom Line: A 19.8 kg heterogeneous retroperitoneal tumor was successfully and completely resected.The recurrent tumor differed from the primary tumor in that it was more homogeneous, consisting mainly of nonlipogenic, calcific tissue.Dedifferentiated liposarcomas are known to have a very high recurrence rate.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Surgery, University of Calgary, Calgary, AB, Canada. karmalis@ucalgary.ca

ABSTRACT

Background: Dedifferentiated liposarcomas represent heterogeneous tumors with lipomatous and nonlipomatous elements starkly juxtaposed. It is thought that the high grade nonlipomatous elements of the tumor portend a worse prognosis.

Case presentation: A 19.8 kg heterogeneous retroperitoneal tumor was successfully and completely resected. Because of its extent, no additional treatment modalities were practicable. The tumor soon recurred. The recurrent tumor differed from the primary tumor in that it was more homogeneous, consisting mainly of nonlipogenic, calcific tissue.

Conclusions: Dedifferentiated liposarcomas are known to have a very high recurrence rate. The biological behavior of dedifferentiated liposarcomas is likely dictated by the most aggressive element of these heterogeneous tumors.

No MeSH data available.


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En bloc resection specimen of heterogeneous tumor with attached organs. Note the lipomatous regions (A), the calcified areas (B), and the remaining nonlipomatous component (C).
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Figure 3: En bloc resection specimen of heterogeneous tumor with attached organs. Note the lipomatous regions (A), the calcified areas (B), and the remaining nonlipomatous component (C).

Mentions: The tumor was submitted for histological examination in two parts measuring, 30.0 × 10.0 × 6.5 cm and 32.0 × 20.0 × 10.0 cm, weighing 19.8 kg in total (Figure 3). On gross examination the mass was variegated, with fleshy and solid cystic degeneration containing areas of osseous consistency. Microscopic examination revealed a juxtaposition of well differentiated liposarcoma and a spindle cell sarcoma with heterologous chondrosarcomatous elements consistent with a dedifferentiated liposarcoma (Figure 4).


A unique dedifferentiated tumor of the retroperitoneum.

Karmali S, Benediktson H, Temple W, Bathe OF - World J Surg Oncol (2004)

En bloc resection specimen of heterogeneous tumor with attached organs. Note the lipomatous regions (A), the calcified areas (B), and the remaining nonlipomatous component (C).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC503399&req=5

Figure 3: En bloc resection specimen of heterogeneous tumor with attached organs. Note the lipomatous regions (A), the calcified areas (B), and the remaining nonlipomatous component (C).
Mentions: The tumor was submitted for histological examination in two parts measuring, 30.0 × 10.0 × 6.5 cm and 32.0 × 20.0 × 10.0 cm, weighing 19.8 kg in total (Figure 3). On gross examination the mass was variegated, with fleshy and solid cystic degeneration containing areas of osseous consistency. Microscopic examination revealed a juxtaposition of well differentiated liposarcoma and a spindle cell sarcoma with heterologous chondrosarcomatous elements consistent with a dedifferentiated liposarcoma (Figure 4).

Bottom Line: A 19.8 kg heterogeneous retroperitoneal tumor was successfully and completely resected.The recurrent tumor differed from the primary tumor in that it was more homogeneous, consisting mainly of nonlipogenic, calcific tissue.Dedifferentiated liposarcomas are known to have a very high recurrence rate.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Surgery, University of Calgary, Calgary, AB, Canada. karmalis@ucalgary.ca

ABSTRACT

Background: Dedifferentiated liposarcomas represent heterogeneous tumors with lipomatous and nonlipomatous elements starkly juxtaposed. It is thought that the high grade nonlipomatous elements of the tumor portend a worse prognosis.

Case presentation: A 19.8 kg heterogeneous retroperitoneal tumor was successfully and completely resected. Because of its extent, no additional treatment modalities were practicable. The tumor soon recurred. The recurrent tumor differed from the primary tumor in that it was more homogeneous, consisting mainly of nonlipogenic, calcific tissue.

Conclusions: Dedifferentiated liposarcomas are known to have a very high recurrence rate. The biological behavior of dedifferentiated liposarcomas is likely dictated by the most aggressive element of these heterogeneous tumors.

No MeSH data available.


Related in: MedlinePlus