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Migraine and type 2 diabetes; is there any association?

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ABSTRACT

Background: Migraine headache prevalence and triggers in type2 diabetes mellitus (T2DM) were investigated in previous studies but the results are contradictory. Therefore, in this study we examined the prevalence of migraine headache in diabetic patients in comparison with non-diabetic persons and its predisposing factors in 2014.

Methods: We enrolled 147 volunteer patients with T2DM and 150 healthy persons referred to the Yazd Diabetes Research Center and the Central Laboratory of Yazd, respectively, in 2014. The data collection instrument was a self-conducted checklist. The checklist contained demographic, anthropometric and clinical characteristics and migraine diagnostic questions according to International Classification of Headache Disorders Second Edition (ICHD-II) criteria. We compared prevalence of migraine between two groups, and also evaluated relationship between above characteristics and migraine prevalence in both groups.

Results: The prevalence of migraine in participants of diabetic and non-diabetic was 27.9 and 26 %, respectively (p-value = .406). The prevalence of migraine headache among in diabetic persons was significantly correlated with family history of migraine, diabetes duration and hypoglycemia attacks. Also, the migraine prevalence was significant more prevalent in T2DM patients with duration 6–10 years (p-value = 0.031). The percentage of HbA1C, type of anti-diabetic medication, BMI value and age in diabetic patients did not show any significant association with migraine.

Conclusion: Although we observed no significant differences in prevalence of migraine between patients with T2DM and non-diabetic age and sex adjusted persons But, the occurrence of hypoglycemia attacks and T2DM duration were related to migraine prevalence. Decreasing hypoglycemia among long-time T2DM patients probably can decline migraine headache in this group of patients.

No MeSH data available.


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Migraine prevalence with p-value of 0.031 related to T2DM duration
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Fig1: Migraine prevalence with p-value of 0.031 related to T2DM duration

Mentions: The prevalence of migraine in diabetics and non-diabetics were 27.9 and 26 %, respectively (P-value = .406) (Table 1) . The prevalence of migraine in diabetic patients with a family history of migraine in first degree relatives and without the history was 50 and 20.9 %, respectively (p-value > 0.001), and the prevalence of migraine in diabetic persons with a history of hypoglycemia and without the history was 41.2 and 16.7 %, respectively (p-value > 0.001). Duration of diabetes was significantly associated with migraine prevalence (p-value = .031) (Fig. 1). The migraine prevalence in patients treated with insulin, oral anti-diabetic agents and no medication were 27.9, 29.5 and 23.1 %, respectively (p-value = 0.549) (Fig. 2). Also, no significant difference was found in the prevalence of migraine in diabetic patients with high levels of HbA1c (poor control of diabetics) (Fig. 3). Also, the age and BMI in diabetics and non-diabetics indicated no significant correlation with migraine prevalence (Figs. 4 and 5). The complementary comparisons between two groups were described in Table 2.Table 1


Migraine and type 2 diabetes; is there any association?
Migraine prevalence with p-value of 0.031 related to T2DM duration
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5016935&req=5

Fig1: Migraine prevalence with p-value of 0.031 related to T2DM duration
Mentions: The prevalence of migraine in diabetics and non-diabetics were 27.9 and 26 %, respectively (P-value = .406) (Table 1) . The prevalence of migraine in diabetic patients with a family history of migraine in first degree relatives and without the history was 50 and 20.9 %, respectively (p-value > 0.001), and the prevalence of migraine in diabetic persons with a history of hypoglycemia and without the history was 41.2 and 16.7 %, respectively (p-value > 0.001). Duration of diabetes was significantly associated with migraine prevalence (p-value = .031) (Fig. 1). The migraine prevalence in patients treated with insulin, oral anti-diabetic agents and no medication were 27.9, 29.5 and 23.1 %, respectively (p-value = 0.549) (Fig. 2). Also, no significant difference was found in the prevalence of migraine in diabetic patients with high levels of HbA1c (poor control of diabetics) (Fig. 3). Also, the age and BMI in diabetics and non-diabetics indicated no significant correlation with migraine prevalence (Figs. 4 and 5). The complementary comparisons between two groups were described in Table 2.Table 1

View Article: PubMed Central - PubMed

ABSTRACT

Background: Migraine headache prevalence and triggers in type2 diabetes mellitus (T2DM) were investigated in previous studies but the results are contradictory. Therefore, in this study we examined the prevalence of migraine headache in diabetic patients in comparison with non-diabetic persons and its predisposing factors in 2014.

Methods: We enrolled 147 volunteer patients with T2DM and 150 healthy persons referred to the Yazd Diabetes Research Center and the Central Laboratory of Yazd, respectively, in 2014. The data collection instrument was a self-conducted checklist. The checklist contained demographic, anthropometric and clinical characteristics and migraine diagnostic questions according to International Classification of Headache Disorders Second Edition (ICHD-II) criteria. We compared prevalence of migraine between two groups, and also evaluated relationship between above characteristics and migraine prevalence in both groups.

Results: The prevalence of migraine in participants of diabetic and non-diabetic was 27.9 and 26 %, respectively (p-value = .406). The prevalence of migraine headache among in diabetic persons was significantly correlated with family history of migraine, diabetes duration and hypoglycemia attacks. Also, the migraine prevalence was significant more prevalent in T2DM patients with duration 6–10 years (p-value = 0.031). The percentage of HbA1C, type of anti-diabetic medication, BMI value and age in diabetic patients did not show any significant association with migraine.

Conclusion: Although we observed no significant differences in prevalence of migraine between patients with T2DM and non-diabetic age and sex adjusted persons But, the occurrence of hypoglycemia attacks and T2DM duration were related to migraine prevalence. Decreasing hypoglycemia among long-time T2DM patients probably can decline migraine headache in this group of patients.

No MeSH data available.


Related in: MedlinePlus