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Kawasaki disease associated with Mycoplasma pneumoniae

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ABSTRACT

Background: Kawasaki disease (KD) is an illness of unknown etiology that mostly occurs in children under 5 years of age and is the leading cause of acquired heart disease all over the world. Mycoplasma pneumoniae (MP) was one of the likely causative agents of KD. However, the etiologic effect of MP in KD has not been fully recognized.

Methods: We prospectively analyzed the clinical records of 450 patients with KD hospitalized in Children’s Hospital of Soochow University from 2012 to 2014. Using medical records, we retrospectively identified patients with low respiratory tract infection (non-KD group).

Results: Of the 450 KD patients, MP was positive in 62 (13.8 %). The median age of the MP + KD+ group was significantly older than the MP-KD+ group (25 vs 14.5 months, P < 0.01). MP + KD+ group had higher levels of ESR, N% and CRP than the MP-KD+ group. MP + KD+ group were more frequent in respiratory disorders than MP-KD+ group with a P < 0.05. No statistical difference of non-responders or coronary artery lesion was found between the groups.

Conclusions: MP infections are found in an important proportion of the KD patients (13.8 % in our series). MP infection tended to occur in older populations and with a higher rate of respiratory tract involvement in patients with KD. No statistical difference of non-responders or coronary artery lesion was found between the MP+ and MP- KD patients.

No MeSH data available.


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Age distribution of MP infection in KD (a) and non-KD (b) patients
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Fig1: Age distribution of MP infection in KD (a) and non-KD (b) patients

Mentions: The MP infection rate in KD patients increased with their age, with a statistical significance for age distribution (P < 0.001). Fewer children younger than 1 year old had MP infection (1.3 %) than those older than 5 years old (28 %) (P < 0.001) (Fig. 1a), indicating that the older children with KD were more prone to MP infection. The age distribution of MP infection in KD group was similar to that in non-KD group (Fig. 1b).Fig. 1


Kawasaki disease associated with Mycoplasma pneumoniae
Age distribution of MP infection in KD (a) and non-KD (b) patients
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5016862&req=5

Fig1: Age distribution of MP infection in KD (a) and non-KD (b) patients
Mentions: The MP infection rate in KD patients increased with their age, with a statistical significance for age distribution (P < 0.001). Fewer children younger than 1 year old had MP infection (1.3 %) than those older than 5 years old (28 %) (P < 0.001) (Fig. 1a), indicating that the older children with KD were more prone to MP infection. The age distribution of MP infection in KD group was similar to that in non-KD group (Fig. 1b).Fig. 1

View Article: PubMed Central - PubMed

ABSTRACT

Background: Kawasaki disease (KD) is an illness of unknown etiology that mostly occurs in children under 5&nbsp;years of age and is the leading cause of acquired heart disease all over the world. Mycoplasma pneumoniae (MP) was one of the likely causative agents of KD. However, the etiologic effect of MP in KD has not been fully recognized.

Methods: We prospectively analyzed the clinical records of 450 patients with KD hospitalized in Children&rsquo;s Hospital of Soochow University from 2012 to 2014. Using medical records, we retrospectively identified patients with low respiratory tract infection (non-KD group).

Results: Of the 450 KD patients, MP was positive in 62 (13.8&nbsp;%). The median age of the MP&thinsp;+&thinsp;KD+ group was significantly older than the MP-KD+ group (25 vs 14.5&nbsp;months, P&thinsp;&lt;&thinsp;0.01). MP&thinsp;+&thinsp;KD+ group had higher levels of ESR, N% and CRP than the MP-KD+ group. MP&thinsp;+&thinsp;KD+ group were more frequent in respiratory disorders than MP-KD+ group with a P&thinsp;&lt;&thinsp;0.05. No statistical difference of non-responders or coronary artery lesion was found between the groups.

Conclusions: MP infections are found in an important proportion of the KD patients (13.8&nbsp;% in our series). MP infection tended to occur in older populations and with a higher rate of respiratory tract involvement in patients with KD. No statistical difference of non-responders or coronary artery lesion was found between the MP+ and MP- KD patients.

No MeSH data available.


Related in: MedlinePlus