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Melanoma with gastric metastases

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ABSTRACT

An 81-year-old woman with a history of malignant melanoma who presented with dyspnea and fatigue was found to have metastases to the stomach detected on endoscopy. Primary cutaneous malignant melanoma with gastric metastases is a rare occurrence, and it is often not detected until autopsy because of its non-specific manifestations.

No MeSH data available.


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Slide stained with an antibody to melanoma marker HMB45 at 10× magnification. The cells of the melanoma strongly express HMB45 as evidenced by brown cytoplasmic staining in the melanoma cells. The benign gastric glands are negative for HMB45.
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Figure 0005: Slide stained with an antibody to melanoma marker HMB45 at 10× magnification. The cells of the melanoma strongly express HMB45 as evidenced by brown cytoplasmic staining in the melanoma cells. The benign gastric glands are negative for HMB45.

Mentions: Given her anemia and history of melanoma, an upper endoscopy was performed. In the stomach, there were multiple hyperpigmented lesions involving the cardia, fundus, and body, all varying in size, shape, and morphology (Figs. 1–2). Some were macular, and some appeared to be ulcerative and umbilicated. In the duodenum, a solitary hyperpigmented lesion was noted. Multiple cold biopsies were obtained. A digital rectal examination showed non-bleeding internal hemorrhoids. A colonoscopy was also performed which revealed only scattered diverticuli. Pathology revealed that the lamina propria of both the duodenum and stomach was infiltrated by a population of single, atypical, and pigmented discohesive cells (Figs. 3–4). The cells expressed the melanoma marker HMB-45 on immunohistochemical stains, which were weakly positive for S-100 protein (Fig. 5).


Melanoma with gastric metastases
Slide stained with an antibody to melanoma marker HMB45 at 10× magnification. The cells of the melanoma strongly express HMB45 as evidenced by brown cytoplasmic staining in the melanoma cells. The benign gastric glands are negative for HMB45.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5016813&req=5

Figure 0005: Slide stained with an antibody to melanoma marker HMB45 at 10× magnification. The cells of the melanoma strongly express HMB45 as evidenced by brown cytoplasmic staining in the melanoma cells. The benign gastric glands are negative for HMB45.
Mentions: Given her anemia and history of melanoma, an upper endoscopy was performed. In the stomach, there were multiple hyperpigmented lesions involving the cardia, fundus, and body, all varying in size, shape, and morphology (Figs. 1–2). Some were macular, and some appeared to be ulcerative and umbilicated. In the duodenum, a solitary hyperpigmented lesion was noted. Multiple cold biopsies were obtained. A digital rectal examination showed non-bleeding internal hemorrhoids. A colonoscopy was also performed which revealed only scattered diverticuli. Pathology revealed that the lamina propria of both the duodenum and stomach was infiltrated by a population of single, atypical, and pigmented discohesive cells (Figs. 3–4). The cells expressed the melanoma marker HMB-45 on immunohistochemical stains, which were weakly positive for S-100 protein (Fig. 5).

View Article: PubMed Central - PubMed

ABSTRACT

An 81-year-old woman with a history of malignant melanoma who presented with dyspnea and fatigue was found to have metastases to the stomach detected on endoscopy. Primary cutaneous malignant melanoma with gastric metastases is a rare occurrence, and it is often not detected until autopsy because of its non-specific manifestations.

No MeSH data available.


Related in: MedlinePlus