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Melanoma with gastric metastases

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ABSTRACT

An 81-year-old woman with a history of malignant melanoma who presented with dyspnea and fatigue was found to have metastases to the stomach detected on endoscopy. Primary cutaneous malignant melanoma with gastric metastases is a rare occurrence, and it is often not detected until autopsy because of its non-specific manifestations.

No MeSH data available.


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H&E stained slide at 40× magnification demonstrating the cells of the malignant melanoma infiltrating benign gastric glands. The nuclei of the melanoma are large, irregular, and hyperchromatic. Brown to black granular melanin pigment is seen associated with the cells of the melanoma.
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Figure 0004: H&E stained slide at 40× magnification demonstrating the cells of the malignant melanoma infiltrating benign gastric glands. The nuclei of the melanoma are large, irregular, and hyperchromatic. Brown to black granular melanin pigment is seen associated with the cells of the melanoma.

Mentions: Given her anemia and history of melanoma, an upper endoscopy was performed. In the stomach, there were multiple hyperpigmented lesions involving the cardia, fundus, and body, all varying in size, shape, and morphology (Figs. 1–2). Some were macular, and some appeared to be ulcerative and umbilicated. In the duodenum, a solitary hyperpigmented lesion was noted. Multiple cold biopsies were obtained. A digital rectal examination showed non-bleeding internal hemorrhoids. A colonoscopy was also performed which revealed only scattered diverticuli. Pathology revealed that the lamina propria of both the duodenum and stomach was infiltrated by a population of single, atypical, and pigmented discohesive cells (Figs. 3–4). The cells expressed the melanoma marker HMB-45 on immunohistochemical stains, which were weakly positive for S-100 protein (Fig. 5).


Melanoma with gastric metastases
H&E stained slide at 40× magnification demonstrating the cells of the malignant melanoma infiltrating benign gastric glands. The nuclei of the melanoma are large, irregular, and hyperchromatic. Brown to black granular melanin pigment is seen associated with the cells of the melanoma.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5016813&req=5

Figure 0004: H&E stained slide at 40× magnification demonstrating the cells of the malignant melanoma infiltrating benign gastric glands. The nuclei of the melanoma are large, irregular, and hyperchromatic. Brown to black granular melanin pigment is seen associated with the cells of the melanoma.
Mentions: Given her anemia and history of melanoma, an upper endoscopy was performed. In the stomach, there were multiple hyperpigmented lesions involving the cardia, fundus, and body, all varying in size, shape, and morphology (Figs. 1–2). Some were macular, and some appeared to be ulcerative and umbilicated. In the duodenum, a solitary hyperpigmented lesion was noted. Multiple cold biopsies were obtained. A digital rectal examination showed non-bleeding internal hemorrhoids. A colonoscopy was also performed which revealed only scattered diverticuli. Pathology revealed that the lamina propria of both the duodenum and stomach was infiltrated by a population of single, atypical, and pigmented discohesive cells (Figs. 3–4). The cells expressed the melanoma marker HMB-45 on immunohistochemical stains, which were weakly positive for S-100 protein (Fig. 5).

View Article: PubMed Central - PubMed

ABSTRACT

An 81-year-old woman with a history of malignant melanoma who presented with dyspnea and fatigue was found to have metastases to the stomach detected on endoscopy. Primary cutaneous malignant melanoma with gastric metastases is a rare occurrence, and it is often not detected until autopsy because of its non-specific manifestations.

No MeSH data available.


Related in: MedlinePlus