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Melanoma with gastric metastases

View Article: PubMed Central - PubMed

ABSTRACT

An 81-year-old woman with a history of malignant melanoma who presented with dyspnea and fatigue was found to have metastases to the stomach detected on endoscopy. Primary cutaneous malignant melanoma with gastric metastases is a rare occurrence, and it is often not detected until autopsy because of its non-specific manifestations.

No MeSH data available.


Endoscopic images demonstrating a solitary hyperpigmented lesion in the duodenum (A) and multiple hyperpigmented lesions involving the cardia and fundus (B–D).
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Figure 0002: Endoscopic images demonstrating a solitary hyperpigmented lesion in the duodenum (A) and multiple hyperpigmented lesions involving the cardia and fundus (B–D).

Mentions: Given her anemia and history of melanoma, an upper endoscopy was performed. In the stomach, there were multiple hyperpigmented lesions involving the cardia, fundus, and body, all varying in size, shape, and morphology (Figs. 1–2). Some were macular, and some appeared to be ulcerative and umbilicated. In the duodenum, a solitary hyperpigmented lesion was noted. Multiple cold biopsies were obtained. A digital rectal examination showed non-bleeding internal hemorrhoids. A colonoscopy was also performed which revealed only scattered diverticuli. Pathology revealed that the lamina propria of both the duodenum and stomach was infiltrated by a population of single, atypical, and pigmented discohesive cells (Figs. 3–4). The cells expressed the melanoma marker HMB-45 on immunohistochemical stains, which were weakly positive for S-100 protein (Fig. 5).


Melanoma with gastric metastases
Endoscopic images demonstrating a solitary hyperpigmented lesion in the duodenum (A) and multiple hyperpigmented lesions involving the cardia and fundus (B–D).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5016813&req=5

Figure 0002: Endoscopic images demonstrating a solitary hyperpigmented lesion in the duodenum (A) and multiple hyperpigmented lesions involving the cardia and fundus (B–D).
Mentions: Given her anemia and history of melanoma, an upper endoscopy was performed. In the stomach, there were multiple hyperpigmented lesions involving the cardia, fundus, and body, all varying in size, shape, and morphology (Figs. 1–2). Some were macular, and some appeared to be ulcerative and umbilicated. In the duodenum, a solitary hyperpigmented lesion was noted. Multiple cold biopsies were obtained. A digital rectal examination showed non-bleeding internal hemorrhoids. A colonoscopy was also performed which revealed only scattered diverticuli. Pathology revealed that the lamina propria of both the duodenum and stomach was infiltrated by a population of single, atypical, and pigmented discohesive cells (Figs. 3–4). The cells expressed the melanoma marker HMB-45 on immunohistochemical stains, which were weakly positive for S-100 protein (Fig. 5).

View Article: PubMed Central - PubMed

ABSTRACT

An 81-year-old woman with a history of malignant melanoma who presented with dyspnea and fatigue was found to have metastases to the stomach detected on endoscopy. Primary cutaneous malignant melanoma with gastric metastases is a rare occurrence, and it is often not detected until autopsy because of its non-specific manifestations.

No MeSH data available.