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Solitary parotid metastasis 8 years after a nephrectomy for renal cell carcinoma

View Article: PubMed Central - PubMed

ABSTRACT

Renal cell carcinoma is a common cancer, known for its aggressive behavior and ability to metastasize nearly every organ system in the body. While the cancer commonly spreads to a select few organs and metastasis usually develops within 5 years of diagnosis, there have been numerous case reports of atypical sites of metastasis and cases of relapse up to decades after treatment. We present a case a 65-year-old male who presented with right preauricular swelling 8 years after the initial diagnosis and right nephrectomy for clear cell renal cell cancer. We take a look at previous case reports with similar presentations.

No MeSH data available.


Related in: MedlinePlus

Histology comparison between current temporal region mass (a) and original renal tumor removed 8 years ago (b). Both images show nests of clear cells with moderate nuclear pleomorphism (200 magnification). Tumor grading did not change (Fuhrman grade 2, ISUP 2013 grade 2).
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Figure 0001: Histology comparison between current temporal region mass (a) and original renal tumor removed 8 years ago (b). Both images show nests of clear cells with moderate nuclear pleomorphism (200 magnification). Tumor grading did not change (Fuhrman grade 2, ISUP 2013 grade 2).

Mentions: The removed mass was a 4.1×3.1×1.8 cm tan-pink encapsulated piece of soft tissue weighing 10.9 g. Its cut surface was approximately 50% tan-brown and 50% tan-white in color. Microscopically, it showed solid trabecular areas of clear cells with an intervening network of small thin-walled vessels (Fig. 1a). The nuclei appeared mostly round with some irregularities, and nucleoli seen at 400× magnification were consistent with a simplified Fuhrman grade 2 of 4 renal cell carcinoma (RCC). Immunohistochemical staining of the mass for RCC and Carbonic Anhydrase IX (CAIX) antigens was positive. Slides from patients’ previous nephrectomy in 2007 were obtained (Fig. 1b) and compared with this specimen and were shown to be similar in morphology.


Solitary parotid metastasis 8 years after a nephrectomy for renal cell carcinoma
Histology comparison between current temporal region mass (a) and original renal tumor removed 8 years ago (b). Both images show nests of clear cells with moderate nuclear pleomorphism (200 magnification). Tumor grading did not change (Fuhrman grade 2, ISUP 2013 grade 2).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5016754&req=5

Figure 0001: Histology comparison between current temporal region mass (a) and original renal tumor removed 8 years ago (b). Both images show nests of clear cells with moderate nuclear pleomorphism (200 magnification). Tumor grading did not change (Fuhrman grade 2, ISUP 2013 grade 2).
Mentions: The removed mass was a 4.1×3.1×1.8 cm tan-pink encapsulated piece of soft tissue weighing 10.9 g. Its cut surface was approximately 50% tan-brown and 50% tan-white in color. Microscopically, it showed solid trabecular areas of clear cells with an intervening network of small thin-walled vessels (Fig. 1a). The nuclei appeared mostly round with some irregularities, and nucleoli seen at 400× magnification were consistent with a simplified Fuhrman grade 2 of 4 renal cell carcinoma (RCC). Immunohistochemical staining of the mass for RCC and Carbonic Anhydrase IX (CAIX) antigens was positive. Slides from patients’ previous nephrectomy in 2007 were obtained (Fig. 1b) and compared with this specimen and were shown to be similar in morphology.

View Article: PubMed Central - PubMed

ABSTRACT

Renal cell carcinoma is a common cancer, known for its aggressive behavior and ability to metastasize nearly every organ system in the body. While the cancer commonly spreads to a select few organs and metastasis usually develops within 5 years of diagnosis, there have been numerous case reports of atypical sites of metastasis and cases of relapse up to decades after treatment. We present a case a 65-year-old male who presented with right preauricular swelling 8 years after the initial diagnosis and right nephrectomy for clear cell renal cell cancer. We take a look at previous case reports with similar presentations.

No MeSH data available.


Related in: MedlinePlus