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Prognostic factors after hepatic resection for the single hepatocellular carcinoma larger than 5 cm

View Article: PubMed Central - PubMed

ABSTRACT

Purpose: This study aimed to determine which factors affect the prognosis of hepatectomy for hepatocellular carcinoma (HCC) larger than 5 cm, including the prognostic difference between tumor sizes from 5–10 cm and larger than 10 cm.

Methods: The medical records of 114 patients who underwent hepatectomy for single HCC larger than 5 cm were reviewed and analyzed retrospectively.

Results: In the analysis of the entire cohort of 114 patients, the 5-year overall and diseases-free survival rates were 50% and 29%, respectively. In a comparison of survival rates between groups, tumor sizes of 5 to 10 cm and larger than 10 cm, the overall and disease-free survival rates were not significantly different, respectively (54% vs. 41%, P = 0.433 and 33% vs. 23%, P = 0.083). On multivariate analysis, positive hepatitis B, high prothrombin induced by vitamin K absence or antagonist-II levels over 200 mIU/mL, and vascular invasion (micro- and macrovascular invasion) were independent prognostic factors for recurrence after hepatic resection. However, tumor size larger than 10 cm was not significant for recurrence after resection.

Conclusion: This study shows that surgical resection of solitary HCC larger than 5 cm showed favorable overall survival. And there is no survival difference with tumors between 5–10 cm and larger than 10 cm.

No MeSH data available.


Related in: MedlinePlus

Overall survival curve (A) and recurrence-free survival curve (B) for entire cohort after surgical resection for single hepatocellular carcinoma larger than 5 cm. The 1-, 3-, and 5-year overall survival rates were 79%, 57%, and 50%. The 1-, 3-, and 5-year recurrence-free survival rates were 53%, 36%, and 29%, respectively.
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Figure 2: Overall survival curve (A) and recurrence-free survival curve (B) for entire cohort after surgical resection for single hepatocellular carcinoma larger than 5 cm. The 1-, 3-, and 5-year overall survival rates were 79%, 57%, and 50%. The 1-, 3-, and 5-year recurrence-free survival rates were 53%, 36%, and 29%, respectively.

Mentions: The median follow-up period was 26.4 months (range, 0.8–159.7 months). During a follow-up period, tumor recurrence occurred in 85 patients (74.6%) and median time to recurrence was 11.2 months after surgery, respectively. At the time of last follow-up, 59 patients (51.8%) had died of recurrent disease progression. In-hospital mortality occurred in only 1 patient (0.9%). For the entire cohort of 114 patients, 1-, 3- and 5-year overall survival rates were 79%, 57%, and 50%, (Fig. 2A) and recurrence-free survival rates were 53%, 36%, and 29%, respectively (Fig. 2B).


Prognostic factors after hepatic resection for the single hepatocellular carcinoma larger than 5 cm
Overall survival curve (A) and recurrence-free survival curve (B) for entire cohort after surgical resection for single hepatocellular carcinoma larger than 5 cm. The 1-, 3-, and 5-year overall survival rates were 79%, 57%, and 50%. The 1-, 3-, and 5-year recurrence-free survival rates were 53%, 36%, and 29%, respectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5016599&req=5

Figure 2: Overall survival curve (A) and recurrence-free survival curve (B) for entire cohort after surgical resection for single hepatocellular carcinoma larger than 5 cm. The 1-, 3-, and 5-year overall survival rates were 79%, 57%, and 50%. The 1-, 3-, and 5-year recurrence-free survival rates were 53%, 36%, and 29%, respectively.
Mentions: The median follow-up period was 26.4 months (range, 0.8–159.7 months). During a follow-up period, tumor recurrence occurred in 85 patients (74.6%) and median time to recurrence was 11.2 months after surgery, respectively. At the time of last follow-up, 59 patients (51.8%) had died of recurrent disease progression. In-hospital mortality occurred in only 1 patient (0.9%). For the entire cohort of 114 patients, 1-, 3- and 5-year overall survival rates were 79%, 57%, and 50%, (Fig. 2A) and recurrence-free survival rates were 53%, 36%, and 29%, respectively (Fig. 2B).

View Article: PubMed Central - PubMed

ABSTRACT

Purpose: This study aimed to determine which factors affect the prognosis of hepatectomy for hepatocellular carcinoma (HCC) larger than 5 cm, including the prognostic difference between tumor sizes from 5–10 cm and larger than 10 cm.

Methods: The medical records of 114 patients who underwent hepatectomy for single HCC larger than 5 cm were reviewed and analyzed retrospectively.

Results: In the analysis of the entire cohort of 114 patients, the 5-year overall and diseases-free survival rates were 50% and 29%, respectively. In a comparison of survival rates between groups, tumor sizes of 5 to 10 cm and larger than 10 cm, the overall and disease-free survival rates were not significantly different, respectively (54% vs. 41%, P = 0.433 and 33% vs. 23%, P = 0.083). On multivariate analysis, positive hepatitis B, high prothrombin induced by vitamin K absence or antagonist-II levels over 200 mIU/mL, and vascular invasion (micro- and macrovascular invasion) were independent prognostic factors for recurrence after hepatic resection. However, tumor size larger than 10 cm was not significant for recurrence after resection.

Conclusion: This study shows that surgical resection of solitary HCC larger than 5 cm showed favorable overall survival. And there is no survival difference with tumors between 5–10 cm and larger than 10 cm.

No MeSH data available.


Related in: MedlinePlus