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Dialkylcarbamoyl chloride-impregnated dressing for the prevention of surgical site infection in women undergoing cesarean section: a pilot study

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ABSTRACT

Introduction: Incisional surgical site infections (SSIs) occur in approximately 1.8–9.2% of patients undergoing cesarean section (CS) and contribute to prolonged hospitalization time and increased treatment costs. Dressings impregnated with dialkylcarbamoyl chloride (DACC) are an innovative approach to wound treatment based on a solely physical mechanism of action, and therefore can be used safely and without time restrictions in women during the puerperal and lactation period.

Material and methods: A single-blinded randomized, controlled pilot study was conducted at the Mazovian Bródno Hospital, a tertiary care hospital, between December 2013 and March 2014, and it evaluated the presence of superficial and deep SSIs in patients during the first 14 days after a CS. Patients were randomly allocated to receive treatment with either a DACC dressing or a standard surgical dressing.

Results: One hundred and forty-two patients after planned or emergency CS were enrolled in the study. No significant differences between the groups were observed with regard to patients’ basic demographic and perioperative characteristics. The rate of superficial and deep SSIs was 2.8% in the group of patients who received a DACC dressing compared to 9.8% in the group with a standard surgical dressing (p = 0.08). Patients with SSIs who received a standard surgical dressing required systemic antibiotic therapy significantly more frequently (p = 0.03). Based on the logistic regression model developed, the pre-pregnancy body mass index was the only statistically significant risk factor for SSI (p = 0.015).

Conclusions: The results of the pilot study indicate a decreasing tendency of the SSI rate in patients after a CS who received DACC impregnated dressings.

No MeSH data available.


CONSORT 2010 flow diagram of the recruitment process and randomizationCS – cesarean section, DACC – dialkylcarbamoyl chloride.
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Figure 0001: CONSORT 2010 flow diagram of the recruitment process and randomizationCS – cesarean section, DACC – dialkylcarbamoyl chloride.

Mentions: In the period between December 2013 and March 2014 at the Department of Obstetrics, Gynecology and Oncology 193 patients underwent CS, and 31 of them did not meet the study inclusion criteria. One hundred and sixty-two participants were randomized, however 20 women (10 in each group) did not report for scheduled follow-up visits and were excluded from the analysis, leaving a total of 142 eligible patients. The number of participants evaluable for final analysis was equal in both groups – 71 patients in the group with a DACC-impregnated dressing (study group) and in the group with a standard surgical dressing (control group). The patient recruitment process and randomization are summarized in the CONSORT 2010 flow diagram (Figure 1).


Dialkylcarbamoyl chloride-impregnated dressing for the prevention of surgical site infection in women undergoing cesarean section: a pilot study
CONSORT 2010 flow diagram of the recruitment process and randomizationCS – cesarean section, DACC – dialkylcarbamoyl chloride.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5016568&req=5

Figure 0001: CONSORT 2010 flow diagram of the recruitment process and randomizationCS – cesarean section, DACC – dialkylcarbamoyl chloride.
Mentions: In the period between December 2013 and March 2014 at the Department of Obstetrics, Gynecology and Oncology 193 patients underwent CS, and 31 of them did not meet the study inclusion criteria. One hundred and sixty-two participants were randomized, however 20 women (10 in each group) did not report for scheduled follow-up visits and were excluded from the analysis, leaving a total of 142 eligible patients. The number of participants evaluable for final analysis was equal in both groups – 71 patients in the group with a DACC-impregnated dressing (study group) and in the group with a standard surgical dressing (control group). The patient recruitment process and randomization are summarized in the CONSORT 2010 flow diagram (Figure 1).

View Article: PubMed Central - PubMed

ABSTRACT

Introduction: Incisional surgical site infections (SSIs) occur in approximately 1.8–9.2% of patients undergoing cesarean section (CS) and contribute to prolonged hospitalization time and increased treatment costs. Dressings impregnated with dialkylcarbamoyl chloride (DACC) are an innovative approach to wound treatment based on a solely physical mechanism of action, and therefore can be used safely and without time restrictions in women during the puerperal and lactation period.

Material and methods: A single-blinded randomized, controlled pilot study was conducted at the Mazovian Bródno Hospital, a tertiary care hospital, between December 2013 and March 2014, and it evaluated the presence of superficial and deep SSIs in patients during the first 14 days after a CS. Patients were randomly allocated to receive treatment with either a DACC dressing or a standard surgical dressing.

Results: One hundred and forty-two patients after planned or emergency CS were enrolled in the study. No significant differences between the groups were observed with regard to patients’ basic demographic and perioperative characteristics. The rate of superficial and deep SSIs was 2.8% in the group of patients who received a DACC dressing compared to 9.8% in the group with a standard surgical dressing (p = 0.08). Patients with SSIs who received a standard surgical dressing required systemic antibiotic therapy significantly more frequently (p = 0.03). Based on the logistic regression model developed, the pre-pregnancy body mass index was the only statistically significant risk factor for SSI (p = 0.015).

Conclusions: The results of the pilot study indicate a decreasing tendency of the SSI rate in patients after a CS who received DACC impregnated dressings.

No MeSH data available.