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The Use of Adipose-Derived Progenitor Cells and Platelet-Rich Plasma Combination for the Treatment of Supraspinatus Tendinopathy in 55 Dogs: A Retrospective Study

View Article: PubMed Central - PubMed

ABSTRACT

Objective: To report clinical findings and outcomes for 55 dogs with supraspinatus tendinopathy (ST) treated with adipose-derived progenitor cells and platelet-rich plasma (ADPC-PRP) therapy.

Methods: Medical records of client-owned dogs diagnosed with ST that were treated with ADPC-PRP combination therapy were reviewed from 2006 to 2013. Data collected included signalment, medical history, limb involvement, prior treatments, physical and orthopedic examination, objective temporospatial gait analysis findings, diagnostic imaging results (radiography, magnetic resonance imaging, musculoskeletal ultrasonography), arthroscopy findings, and outcome.

Results: Following ultrasound-guided injection of ADPC-PRP, objective gait analysis was available on 25 of the 55 dogs at 90 days post ADPC-PRP therapy. Following treatment, a significant increase in total pressure index percentage (TPI%) was noted in the injured (treated) forelimb at 90 days post treatment (p = 0.036). At 90 days following treatment, 88% of cases had no significant difference in TPI% of the injured limb to the contralateral limb. The remaining 12% of cases had significantly improved (p = 0.036). Bilateral shoulder diagnostic musculoskeletal ultrasound revealed a significant reduction in tendon size (CSA) in the treated tendon at 90 days following treatment when compared to the initial CSA (p = 0.005). All cases showed significant improvement in fiber pattern of the affected supraspinatus tendon by the ultrasound shoulder pathology rating scale.

Clinical relevance: These findings suggest that ADPC-PRP therapy should be considered for dogs with ST.

No MeSH data available.


The total pressure index percentage (TPI%) of the affected limb in individual patients at days 0 and 90.
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Figure 5: The total pressure index percentage (TPI%) of the affected limb in individual patients at days 0 and 90.

Mentions: There was a significant difference in CSA noted between the injured and contralateral normal supraspinatus tendon prior to ADPC-PRP therapy (p = 0.002; Figures 4E and 5). No significant difference in CSA was noted between the injured and contralateral normal supraspinatus tendon at 45 and 90 days post treatment (Figure 5). Following treatment, a significant reduction in tendon size (CSA) was noted in the treated tendon at both 45 and 90 days following treatment when compared to the initial CSA (p = 0.001; p = 0.005; Figures 6 and 7). Reduction in supraspinatus size was noted in all cases with 82% of cases reaching the contralateral supraspinatus size. All cases showed improvement in fiber pattern of the affected supraspinatus tendon at both 45 and 90 days following treatment.


The Use of Adipose-Derived Progenitor Cells and Platelet-Rich Plasma Combination for the Treatment of Supraspinatus Tendinopathy in 55 Dogs: A Retrospective Study
The total pressure index percentage (TPI%) of the affected limb in individual patients at days 0 and 90.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5016533&req=5

Figure 5: The total pressure index percentage (TPI%) of the affected limb in individual patients at days 0 and 90.
Mentions: There was a significant difference in CSA noted between the injured and contralateral normal supraspinatus tendon prior to ADPC-PRP therapy (p = 0.002; Figures 4E and 5). No significant difference in CSA was noted between the injured and contralateral normal supraspinatus tendon at 45 and 90 days post treatment (Figure 5). Following treatment, a significant reduction in tendon size (CSA) was noted in the treated tendon at both 45 and 90 days following treatment when compared to the initial CSA (p = 0.001; p = 0.005; Figures 6 and 7). Reduction in supraspinatus size was noted in all cases with 82% of cases reaching the contralateral supraspinatus size. All cases showed improvement in fiber pattern of the affected supraspinatus tendon at both 45 and 90 days following treatment.

View Article: PubMed Central - PubMed

ABSTRACT

Objective: To report clinical findings and outcomes for 55 dogs with supraspinatus tendinopathy (ST) treated with adipose-derived progenitor cells and platelet-rich plasma (ADPC-PRP) therapy.

Methods: Medical records of client-owned dogs diagnosed with ST that were treated with ADPC-PRP combination therapy were reviewed from 2006 to 2013. Data collected included signalment, medical history, limb involvement, prior treatments, physical and orthopedic examination, objective temporospatial gait analysis findings, diagnostic imaging results (radiography, magnetic resonance imaging, musculoskeletal ultrasonography), arthroscopy findings, and outcome.

Results: Following ultrasound-guided injection of ADPC-PRP, objective gait analysis was available on 25 of the 55 dogs at 90 days post ADPC-PRP therapy. Following treatment, a significant increase in total pressure index percentage (TPI%) was noted in the injured (treated) forelimb at 90 days post treatment (p = 0.036). At 90 days following treatment, 88% of cases had no significant difference in TPI% of the injured limb to the contralateral limb. The remaining 12% of cases had significantly improved (p = 0.036). Bilateral shoulder diagnostic musculoskeletal ultrasound revealed a significant reduction in tendon size (CSA) in the treated tendon at 90 days following treatment when compared to the initial CSA (p = 0.005). All cases showed significant improvement in fiber pattern of the affected supraspinatus tendon by the ultrasound shoulder pathology rating scale.

Clinical relevance: These findings suggest that ADPC-PRP therapy should be considered for dogs with ST.

No MeSH data available.