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Uterine Clear Cell Carcinoma of Postmenopausal Woman: A Case Report

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ABSTRACT

Endometrial cancer is the most common gynecologic malignancy in developed countries. Clear cell carcinoma typically occurs in the ovaries, and very rarely occurs in the endometrium; it accounts for less than 3% of all endometrial cancers. It is presumed that clear cell carcinomas are of Müllerian duct origin, and an association with exposure to diethylstilbestrol (DES) or other nonsteroidal follicle stimulating hormones has been described. We report a case of a postmenopausal woman who presented with vaginal bleeding without a specific medical history. Under the impression of an endometrial mass, we performed a laparoscopic operation. Pathologic results showed clear cell carcinoma of the endometrium. Depth of invasion was 0.2 cm out of a 0.5 cm total thickness, and the rectal shelf mass was clear cell carcinoma. We report the case with a brief review of the relevant literature.

No MeSH data available.


(A) Ultrasound sonography findings showing an endometrial mass. (B) Hysteroscopic findings in the endometrial cavity.
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Figure 1: (A) Ultrasound sonography findings showing an endometrial mass. (B) Hysteroscopic findings in the endometrial cavity.

Mentions: A 66-year-old woman (141 cm, 46 kg, body mass index [BMI] 23.2 kg/m2), gravida 3 was admitted to our Obstetrics & Gynecology hospital, and her chief complaint was vaginal spotting which occurred a month ago. She had hypertension and took medical therapy. Under the impression of endometrial mass, tumor marker, complete blood cell count, serum chemistry, ultrasound sonography (USG), hysteroscopy were done. Cancer antigen 125 (CA-125) is 22.5 U/mL, USG image showed large mass in endometrial cavity and hysteroscopic biopsy result is clear cell carcinoma (Fig. 1). Positron emission tomography (PET)-computed tomography (CT) image showed diffuse heterogeneous hypermetabolic lesion in the endometrial cavity and focal hypermetabolic lesion between the right aspect of rectum and uterus (Fig. 2). Laparoscopic assisted hysterectomy with bilateral salpingo-oophorectomy (BSO), pelvic lymph node dissection and rectal shelf mass removal was done (Fig. 2). Pathologic report was clear cell carcinoma of the endometrium, depth of invasion was 0.2 cm out of 0.5 cm thickness, rectal shelf mass was clear cell carcinoma. Postoperative radiotherapy was performed and the patient is currently under outpatient follow-up with subclinical conditions.


Uterine Clear Cell Carcinoma of Postmenopausal Woman: A Case Report
(A) Ultrasound sonography findings showing an endometrial mass. (B) Hysteroscopic findings in the endometrial cavity.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5016501&req=5

Figure 1: (A) Ultrasound sonography findings showing an endometrial mass. (B) Hysteroscopic findings in the endometrial cavity.
Mentions: A 66-year-old woman (141 cm, 46 kg, body mass index [BMI] 23.2 kg/m2), gravida 3 was admitted to our Obstetrics & Gynecology hospital, and her chief complaint was vaginal spotting which occurred a month ago. She had hypertension and took medical therapy. Under the impression of endometrial mass, tumor marker, complete blood cell count, serum chemistry, ultrasound sonography (USG), hysteroscopy were done. Cancer antigen 125 (CA-125) is 22.5 U/mL, USG image showed large mass in endometrial cavity and hysteroscopic biopsy result is clear cell carcinoma (Fig. 1). Positron emission tomography (PET)-computed tomography (CT) image showed diffuse heterogeneous hypermetabolic lesion in the endometrial cavity and focal hypermetabolic lesion between the right aspect of rectum and uterus (Fig. 2). Laparoscopic assisted hysterectomy with bilateral salpingo-oophorectomy (BSO), pelvic lymph node dissection and rectal shelf mass removal was done (Fig. 2). Pathologic report was clear cell carcinoma of the endometrium, depth of invasion was 0.2 cm out of 0.5 cm thickness, rectal shelf mass was clear cell carcinoma. Postoperative radiotherapy was performed and the patient is currently under outpatient follow-up with subclinical conditions.

View Article: PubMed Central - PubMed

ABSTRACT

Endometrial cancer is the most common gynecologic malignancy in developed countries. Clear cell carcinoma typically occurs in the ovaries, and very rarely occurs in the endometrium; it accounts for less than 3% of all endometrial cancers. It is presumed that clear cell carcinomas are of Müllerian duct origin, and an association with exposure to diethylstilbestrol (DES) or other nonsteroidal follicle stimulating hormones has been described. We report a case of a postmenopausal woman who presented with vaginal bleeding without a specific medical history. Under the impression of an endometrial mass, we performed a laparoscopic operation. Pathologic results showed clear cell carcinoma of the endometrium. Depth of invasion was 0.2 cm out of a 0.5 cm total thickness, and the rectal shelf mass was clear cell carcinoma. We report the case with a brief review of the relevant literature.

No MeSH data available.