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Dehydrated Human Amnion/Chorion Grafts May Accelerate the Healing of Ulcers on Free Flaps in Patients With Venous Insufficiency and/or Lymphedema

View Article: PubMed Central - PubMed

ABSTRACT

Objective:methods:results:conclusions:: Ulceration of free flaps in patients with venous insufficiency and/or lymphedema is an uncommon but challenging problem. We hypothesized that dehydrated human amnion/chorion membrane (Epifix) grafts would accelerate healing of these challenging ulcers. Retrospective analysis of prospectively acquired data identified 8 lower extremity free flaps with ulcerations in the context of venous insufficiency and/or lymphedema. The first 4 were flaps that had been treated with conservative wound care to healing. The second group was treated conservatively initially but then converted to treatment with dehydrated human amnion/chorion membrane grafts. The primary endpoint was time to healing. Comparison of Kaplan-Meier survival curves revealed a significant difference between the conservatively and dehydrated human amnion/chorion membrane–treated flap ulcers, favoring graft treatment (P = .0361). In those ulcers that healed, the average time to healing was 87 days for the conservative treatment group and 33 days for the dehydrated human amnion/chorion membrane treatment group (with an average of 1.7 grafts per ulcer). Dehydrated human amnion/chorion membrane may accelerate healing of ulcers on lower extremity free flaps in patient with lymphedema and/or venous disease in the treated leg.

No MeSH data available.


Related in: MedlinePlus

Ulcer healing over time. dHACM indicates dehydrated human amnion/chorion membrane.
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Figure 1: Ulcer healing over time. dHACM indicates dehydrated human amnion/chorion membrane.

Mentions: Kaplan-Meier survival curves for the conservatively treated and dHACM treatment groups are presented in Figure 1. The hazard rates were different based on the log-rank test, with z = 2.1 and P = .0361, indicating that treatment with dHACM resulted in flap ulcers healing faster than conservative care.


Dehydrated Human Amnion/Chorion Grafts May Accelerate the Healing of Ulcers on Free Flaps in Patients With Venous Insufficiency and/or Lymphedema
Ulcer healing over time. dHACM indicates dehydrated human amnion/chorion membrane.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5016387&req=5

Figure 1: Ulcer healing over time. dHACM indicates dehydrated human amnion/chorion membrane.
Mentions: Kaplan-Meier survival curves for the conservatively treated and dHACM treatment groups are presented in Figure 1. The hazard rates were different based on the log-rank test, with z = 2.1 and P = .0361, indicating that treatment with dHACM resulted in flap ulcers healing faster than conservative care.

View Article: PubMed Central - PubMed

ABSTRACT

Objective:methods:results:conclusions:: Ulceration of free flaps in patients with venous insufficiency and/or lymphedema is an uncommon but challenging problem. We hypothesized that dehydrated human amnion/chorion membrane (Epifix) grafts would accelerate healing of these challenging ulcers. Retrospective analysis of prospectively acquired data identified 8 lower extremity free flaps with ulcerations in the context of venous insufficiency and/or lymphedema. The first 4 were flaps that had been treated with conservative wound care to healing. The second group was treated conservatively initially but then converted to treatment with dehydrated human amnion/chorion membrane grafts. The primary endpoint was time to healing. Comparison of Kaplan-Meier survival curves revealed a significant difference between the conservatively and dehydrated human amnion/chorion membrane–treated flap ulcers, favoring graft treatment (P = .0361). In those ulcers that healed, the average time to healing was 87 days for the conservative treatment group and 33 days for the dehydrated human amnion/chorion membrane treatment group (with an average of 1.7 grafts per ulcer). Dehydrated human amnion/chorion membrane may accelerate healing of ulcers on lower extremity free flaps in patient with lymphedema and/or venous disease in the treated leg.

No MeSH data available.


Related in: MedlinePlus