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Effects of Lizhong Tang on gastrointestinal motility in mice

View Article: PubMed Central - PubMed

ABSTRACT

Aim: To investigate the effects of Lizhong Tang, a traditional Chinese medicine formula, on gastrointestinal motility in mice.

Methods: The in vivo effects of Lizhong Tang on GI motility were investigated by measuring the intestinal transit rates (ITRs) and gastric emptying (GE) values in normal mice and in mice with experimentally induced GI motility dysfunction (GMD).

Results: In normal ICR mice, the ITR and GE values were significantly and dose-dependently increased by Lizhong Tang (ITR values: 54.4% ± 1.9% vs 65.2% ± 1.8%, P < 0.01 with 0.1 g/kg Lizhong Tang and 54.4% ± 1.9% vs 83.8% ± 1.9%, P < 0.01 with 1 g/kg Lizhong Tang; GE values: 60.7% ± 1.9% vs 66.8% ± 2.1%, P < 0.05 with 0.1 g/kg Lizhong Tang and 60.7% ± 1.9% vs 72.5% ± 1.7%, P < 0.01 with 1 g/kg Lizhong Tang). The ITRs of the GMD mice were significantly reduced compared with those of the normal mice, which were significantly and dose-dependently reversed by Lizhong Tang. Additionally, in loperamide- and cisplatin-induced models of GE delay, Lizhong Tang administration reversed the GE deficits.

Conclusion: These results suggest that Lizhong Tang may be a novel candidate for development as a prokinetic treatment for the GI tract.

No MeSH data available.


Effects of the Lizhong Tang extract on the intestinal transit rates (%) in normal mice. Intestinal transit rates (ITRs) (%) values of normal mice that were pretreated with the Lizhong Tang extract prior to Evans blue administration (n = 15 for each bar). The bars represent mean values ± SE. bP < 0.01; Significantly different from the normal controls. PF: Poncirus trifoliate Raf; Lope.: Loperamide.
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Figure 2: Effects of the Lizhong Tang extract on the intestinal transit rates (%) in normal mice. Intestinal transit rates (ITRs) (%) values of normal mice that were pretreated with the Lizhong Tang extract prior to Evans blue administration (n = 15 for each bar). The bars represent mean values ± SE. bP < 0.01; Significantly different from the normal controls. PF: Poncirus trifoliate Raf; Lope.: Loperamide.

Mentions: After 30 min, the mean ITR (%) for Evans blue in normal mice was 54.4% ± 1.9% (Figure 2). PF (1 g/kg), which has been shown to have prokinetic activity in the GI tract[17,18], significantly accelerated the ITR [79.4% ± 2.3% (P < 0.01)], similar to the Lizhong Tang extract, which dose-dependently increased the ITR (%) [ITR values at 0.01, 0.1 and 1 g/kg were 56.1% ± 2.1%, 65.2% ± 1.8% (P < 0.01) and 83.8% ± 1.9% (P < 0.01), respectively; Figure 2]. Loperamide decreased the ITR (%), which is consistent with previous reports[19], and the Lizhong Tang extract inhibited this loperamide-induced decrease in ITR [ITR value for loperamide was 56.1% ± 2.1%; and ITR value for loperamide with the Lizhong Tang extract was 65.2% ± 1.8% (P < 0.01); Figure 2].


Effects of Lizhong Tang on gastrointestinal motility in mice
Effects of the Lizhong Tang extract on the intestinal transit rates (%) in normal mice. Intestinal transit rates (ITRs) (%) values of normal mice that were pretreated with the Lizhong Tang extract prior to Evans blue administration (n = 15 for each bar). The bars represent mean values ± SE. bP < 0.01; Significantly different from the normal controls. PF: Poncirus trifoliate Raf; Lope.: Loperamide.
© Copyright Policy - open-access
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC5016378&req=5

Figure 2: Effects of the Lizhong Tang extract on the intestinal transit rates (%) in normal mice. Intestinal transit rates (ITRs) (%) values of normal mice that were pretreated with the Lizhong Tang extract prior to Evans blue administration (n = 15 for each bar). The bars represent mean values ± SE. bP < 0.01; Significantly different from the normal controls. PF: Poncirus trifoliate Raf; Lope.: Loperamide.
Mentions: After 30 min, the mean ITR (%) for Evans blue in normal mice was 54.4% ± 1.9% (Figure 2). PF (1 g/kg), which has been shown to have prokinetic activity in the GI tract[17,18], significantly accelerated the ITR [79.4% ± 2.3% (P < 0.01)], similar to the Lizhong Tang extract, which dose-dependently increased the ITR (%) [ITR values at 0.01, 0.1 and 1 g/kg were 56.1% ± 2.1%, 65.2% ± 1.8% (P < 0.01) and 83.8% ± 1.9% (P < 0.01), respectively; Figure 2]. Loperamide decreased the ITR (%), which is consistent with previous reports[19], and the Lizhong Tang extract inhibited this loperamide-induced decrease in ITR [ITR value for loperamide was 56.1% ± 2.1%; and ITR value for loperamide with the Lizhong Tang extract was 65.2% ± 1.8% (P < 0.01); Figure 2].

View Article: PubMed Central - PubMed

ABSTRACT

Aim: To investigate the effects of Lizhong Tang, a traditional Chinese medicine formula, on gastrointestinal motility in mice.

Methods: The in vivo effects of Lizhong Tang on GI motility were investigated by measuring the intestinal transit rates (ITRs) and gastric emptying (GE) values in normal mice and in mice with experimentally induced GI motility dysfunction (GMD).

Results: In normal ICR mice, the ITR and GE values were significantly and dose-dependently increased by Lizhong Tang (ITR values: 54.4% &plusmn; 1.9% vs 65.2% &plusmn; 1.8%, P &lt; 0.01 with 0.1 g/kg Lizhong Tang and 54.4% &plusmn; 1.9% vs 83.8% &plusmn; 1.9%, P &lt; 0.01 with 1 g/kg Lizhong Tang; GE values: 60.7% &plusmn; 1.9% vs 66.8% &plusmn; 2.1%, P &lt; 0.05 with 0.1 g/kg Lizhong Tang and 60.7% &plusmn; 1.9% vs 72.5% &plusmn; 1.7%, P &lt; 0.01 with 1 g/kg Lizhong Tang). The ITRs of the GMD mice were significantly reduced compared with those of the normal mice, which were significantly and dose-dependently reversed by Lizhong Tang. Additionally, in loperamide- and cisplatin-induced models of GE delay, Lizhong Tang administration reversed the GE deficits.

Conclusion: These results suggest that Lizhong Tang may be a novel candidate for development as a prokinetic treatment for the GI tract.

No MeSH data available.